Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"c-MYB"”.
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Distinguishing the Role of the c-myb Proto-Oncogene in Mouse Models of Cardiovascular Disease
… the specific roles of transcription factor c-myb in leukocytes, comparatively little is known about c-myb in the context of cardiovascular disease. c-myb regulates vascular smooth muscle cell (VSMC) differentiation from embryonic stem cells, as well as the proliferation of mature VSMCs. The …
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Funktionelle Charakterisierung der humanen Polo-Kinase Plk2/Snk im Zell- und Centrosomenzyklus
… Hilfe des Zwei-Hybrid-Screens in Hefe konnte c-Myb, ein Transkriptionsfaktor der hauptsächlich in hämatopoietischen Zellen exprimiert wird, als Substrat für Plk2 am G1/S-Übergang identifiziert werden. Da die Plk2-Kinase ebenfalls in hämatopoietischen Zellen exprimiert wird, könnte sie die …
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Caracterización de MYBBP como un nuevo gen supresor de tumores
… de glucosa en el que identificamos el gen MYB binding protein 1A (MYBBP1A). MYBBP1A es un regulador de factores de transcripción implicado en la regulación de varios procesos biológicos esenciales. En este trabajo hemos analizado muestras de tumores humanos, confirmando que la pérdida de …
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Examining Altered NF-κB Signalling Following 1,4- Benzoquinone Exposure in HD3 Cells
… pathway involving NF-κB, p38-MAPK and c-Myb. The objectives were to determine if ROS and p38-MAPK mediate benzoquinone (BQ) induced changes in NF-κB activity, and if downstream targets of NF-κB are altered after BQ exposure. HD3 chicken erythroblast cells were transfected with either a …
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IDENTIFYING, CHARACTERIZING AND VERIFYING NOVEL C-MAF FUNCTIONS IN T CELL DEVELOPMENT AND APOPTOSIS
… T cell lineage. In CD4 cells, c-Maf inhibits c-Myb binding to the Bcl-2 P2 promoter by interacting with c-Myb, which in turn disrupts Bcl-2 promoter activity. Downregulation of Bcl-2 expression limits CD4 cell survival following exposure to various stimuli. In CD8 cells, c-Maf transactivates …
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Die transkriptionelle Regulation der Proteintyrosinkinase p 56 lck als Schlüsselenzym der Thymozytenreifung
… und zusammen mit Faktoren der Ets-Familie bzw. c-Myb aktivieren können. Die Untersuchung der Interaktion von NF-AT und c-Myb ergab, dass die beiden Transkriptionsfaktoren unmittelbar benachbart an die DNA binden. Unter Berücksichtigung dieses Bindungsverhaltens und der Kooperation in der …
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Changes in macrophage functions and gene expression during tumor growth
… in normal host and TBH Mφ. The proto-oncogenes c-myb, c-myc, c-fos, and c-fms are constitutively expressed in TBH Mφ, while normal host M@ express c-fos and c-fms but at lower levels. Adherence suppresses the expression of the proto-oncogenes c-myb, c-myc, and c-fms in TBH Mφ, while inducing c-fos …
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Regulation of flt3 gene expression in haematopoietic and leukaemic stem cells
… between the \(in vivo\) binding of C/EBP and c-Myb on regulatory elements and epigenetic remodelling in the differential regulation of \(flt3\) in leukaemic cells. Finally, I identify the histone modifiers TIP60 and CBP as potential mediators of the epigenetic regulation of \(flt3\) in AML cells.
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Regulation and inhibition of pro-tumorigenic microenvironments
… regulator of SASP factor expression, c-myb. I have also identified a post-transcriptional regulatory network composed of p38MAPK and the RNA-binding protein AUF1, which regulates SASP mRNA stability and sustains SASP expression after the induction of senescence. Finally, I have …
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The role of GATA-1 isoforms in haematopoiesis
… with progenitor proliferation (cyclin D2 and c-myb). GATA-1s, in contrast, produced less evidence of differentiation with lower DNA ploidy, less up-regulation of erythroid genes and failure to repress other lineage and haematopoietic progenitor associated genes. Examination of the link with …
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Mechanisms of Erythroid Proliferation and Differentiation: Analysis of the Role of Erythropoietin Receptor in the Friend Virus Model
<p>Terminal erythroid differentiation is a precisely regulated process, in which mature red blood cells are generated from late erythroid progenitor cells. Regulation of cellular proliferation, survival and differentiation determines the fate of those cells. Extracellular signaling molecule, …