Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"c-Kit"”.
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Untersuchungen zur Expression der Rezeptortyrosinkinase c-kit in Thymuskarzinomen und Thymomen
… Aktivierungsstatus der Rezeptortyrosinkinase c-kit in Thymustumoren untersucht und deren diagnostische und klinische Relevanz aufgezeigt. Das c-kit-Gen wurde auf Mutationen untersucht sowie der Aktivierungsstatus im c-kit-Transduktionspfad nachgeschalteter Proteine festgestellt.
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Bedeutung der Rezeptor-Tyrosinkinase c-Kit in der Pathogenese der, Philadelphiatranslokation Bcr-Abl positiven, chronischen myeloischen Leukämie
… Assoziation der Rezeptor-Tyrosinkinase c-Kit mit dem Onkoprotein Bcr-Abl. Es wird in der zeitlichen Abfolge der chronisch myeloischen Leukämie (CML) besonders für die chronische Phase eine Beteiligung des Stammzellfaktors (SCF), dem natürlichen Liganden von c-Kit, an der Proliferation des …
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Keratose Hydrogels Promote Vascular Smooth Muscle Differentiation from c-kit+ Human Cardiac Stem Cells: Underlying Mechanism and Therapeutic Potential
… organ shortages severely limit this therapy. C-kit+ human cardiac stem cells (hCSCs) offers a viable alternative therapy to treat cardiovascular disease by replacing damaged cardiac tissue; however, low cell viability, low retention/engraftment, and uncontrollable in vivo differentiation after …
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Soluble C-Kit Receptor Level May Be a Serological Marker for Predicting the Extent of Upper and Lower Airway Inflammation
… development and survival is dependent on the Kit-mediated activation and this stem cell factor (SCF)/c-kit pathway leads to eosinophil infiltration. We investigated whether SCF/c-kit pathway induced inflammation is associated with both upper and lower airway inflammation. METHODS: We enrolled …
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Transcriptional profile of c-kit positive cardiac stem-progenitor cells (c-kitpos eCSCs) isolated from the four chambers of the adult human heart
… They express the stem cell factor receptor c-kit, are distributed throughout the myocardium, are clonogenic, self-renewing and multi-potent, in that they differentiate into the 3 main cardiac lineages; cardiomyocytes, smooth muscle and endothelial cells in vitro and in vivo. The objective of …
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Characterizing The Effect of Dasatinib On Anti-Tumor Immune Response and Exploring The Potential of Combining Targeted Therapy and Immunotherapy In A C-Kit Mutant Mastocytoma Model
… The mutation and amplification of the c-KIT proto- oncogene are associated with multiple different cancer types, and multiple c-KIT inhibitors have been tested clinically. In spite of some encouraging results using these agents, most patients with c-KIT mutant cancers still relapse due to …
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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction
… To prove this hypothesis, we isolated c-kit+ve cells from four weeks old C57BL/6 mice and cultured them in vitro in presence of ES conditioned media (ESCM), ES-TIMP-1-CM or TIMP-1. Our immunostaining data validate the existence of a novel CD63+ve/c-kit+ve cells. When treated with TIMP-1, …
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The Immunohistological Features of Acquired Bilateral Nevus of Ota-like Macules: Comparison with Melasma and Nevus of Ota
… findings of NKI/beteb, stem cell factor (SCF), c-kit, factor VIIIa-related antigen and vascular endothelial growth factor (VEGF) were examined and quantified by image analysis. RESULTS: In ABNOM, the amount of lesional dermal pigmentation and melanocytes were increased compared to perilesional …
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Signal transduction via multiple BMP receptor complexes
… the interactors, the receptor tyrosine kinase c-kit, was characterized in more detail. It could be demonstrated, that BRII and c-kit form a complex in vitro and in vivo, and the interaction is enhanced upon BMP2 stimulation. 2D phosphopeptid mapping showed that BRII is phosphorylated at S757 upon …
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Erk1 and Erk2 in hematopoiesis, mast cell function, and the management of Nf1-associated leukemia and tumors
… cells depend upon deregulated signaling in c-kit pathways, a receptor system conserved in hematopoietic stem cells (HSCs). Accordingly, Nf1-/- myeloid progenitor cells, which can induce a JMML-like disease in mice, also demonstrate deregulated c-kit receptor signaling. C-kit-activated Nf1+/- …
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PRIMING CARDIOVASCULAR STEM CELLS FOR TRANSPLANTATION USING SHORT-TERM HYPOXIA
… such as those that co-express Isl-1 and c-Kit, may enhance the results reported in clinical trials completed to date. However, the effects of short-term hypoxia in this novel cell type are unknown and warrant investigation <em>in vitro.</em></p> <p>Cloned adult and neonatal Isl-1+ c-Kit+ …
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The Investigation of Targets for Therapy in Brain Tumours
… derived growth factor receptor (PDGFR) and C-Kit, as well as the non-receptor tyrosine kinase C-Abl are often amplified, overexpressed, and/or mutated in gliomas and play an important role in glioma development. A number of tyrosine kinase inhibitors (TKIs) have been developed and tested in …
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Dynamics of Endogenous Cardiac Repair and Methods for Enhanced Post-Injury Cell Therapy
… injury, leading to preferential engraftment of c-kit+ BMCs (which exhibit superior P-selectin adherence in vitro). Chapter 5 adapts the flow cytometry technique to measurement of absolute cell retention (non-ratiometric) to evaluate chemotactic properties of Stromal Derived Factor (SDF)-eluting …
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The role of fibrolast-derived cytokines on melasma
… factor(TNF)-α, interleukin(IL)-1α, and c-kit. The results of staining were analyzed by estimation of three dermatologists and computerized image analysis. There were marked epidermal thinning of the lesional sites than those of perilesional normal sites, and solar elastosis at lesional …
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Regulation of melanogenesis in conditionally immortalised mouse melanocytes expressing a temperature-sensitive SV40 large T antigen
… In addition they expressed the mi gene and the c-kit receptor. In contrast, one dermal melanocyte clone (DMEL-3) gradually depigmented: this was accompanied by enhanced growth and down-regulation of melanocyte-specific gene expression. At the non-permissive temperature of the oncoprotein, …
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Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
… a pathway, where stem cell factor (SCF)-evoked c-Kit-signaling leads to increased HIF-1alpha protein, HRE-activation and induction of several HIF-1alpha targets, such as VEGF and GLUT1, already at normoxia. In addition we find a reciprocal positive feedback loop between c-Kit and HIF-1alpha, where …
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