Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 118 for “"c-Jun"”.
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C/EBPalpha downregualtes c-jun expression
… are present. A dramatic increase of c-jun mRNA in C/EBPa knockout mice fetal liver was observed. c-jun, a component of the AP-1 transcription factor complex and a co-activator of the transcription factor PU.1, is important for monocytic differentiation. Here we report that C/EBPa …
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Translational Regulation of the C-Jun Proto-Oncogene
<p>The <em>v-jun</em> oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation. The c-Jun protein is a transcription factor which binds to the DNA target TGACTCA. The …
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C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy and Antigen Presentation
… infection triggered phosphorylation of c-Jun N-terminal kinases (JNK) that was essential for autophagy. Adenoviral replication within the host cell elicited JNK pathway activation leading to B cell lymphoma-2 (Bcl-2) phosphorylation. JNK-dependent Bcl-2 phosphorylation stimulated the …
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Role of c-Jun in the regulation of tumor suppressor p53 homologue, p73
… the first time that the transcription factor c-Jun stabilizes and activates p73. Genetic evidences consolidated the findings, as c-jun-/- cells are defective in p73 stabilization, transcriptional activation, and are resistant to cisplatin induced apoptosis. Upon introducing c-Jun in c-jun-/- …
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Molekulare Mechanismen der transkriptionellen Aktivierung durch die Transkriptionsfaktoren c-Jun und v-Jun
… Mechanismen der Transkriptionsfunktion von c-Jun und v-Jun in drei verschiedenen Ansätzen untersucht. Im ersten Teil der Arbeit konnte gezeigt werden, dass die transkriptionelle Aktivität von v-Jun, im Gegensatz zu den sauren Transkriptionsfaktoren VP16, GCN4 und Hap4, in S.cerevisiae …
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The role of c-Jun N-terminal kinase one and two in motoneuron maturation and maintenance
… and Kobe, 2006; Frebel and Wiese, 2006). The c-Jun N-terminal kinases (JNKs) are stress-activated members of the MAPK family, which may represent candidate molecules whose signaling is important in MN death, survival, differentiation, maturation, and maintenance. Classically considered a …
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Elevated temperature alters cytokine output and c-Jun N-terminal kinase signaling downstream of toll-like receptor activation
Fever is a fundamental and important response to infection. Previous studies have shown that alterations in temperature can alter the phenotype of innate immune cells, such as phagocytic ability, but the effects of elevated temperature on the molecular mechanisms that underlie these differences …
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Helicobacter Pylori aktiviert den Transkriptionsfaktor AP-1 über mitogen-aktivierte Proteinkaskaden und induziert die Protoonkogene c-fos und c-jun
… konsekutiv die Transaktivierungskapazität von c-Jun durch Phosphorelierung zu erhöhen. <br>Entscheidend hierbei ist, daß nur H.pylori Stämme mit einer intakten Pathogenitätsinsel cag (u.a. Stamm G27) eine Aktivierung der Signalkaskaden und des Transkriptionsfaktors AP-1 bewirken, H.pylori Stämme …
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Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia
Overexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process. However, c-jun expression has not been investigated in acute myeloid leukemia (AML) cells containing the most common …
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Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor
<p>Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotypic changes related to malignant progression including a shift to estrogen independent growth, increased cell motility and invasion. Concurrent with these phenotypic changes are alterations to …
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The <i>Drosophila</i> T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival
… </em>within the insulin receptor (InR) and the c-Jun-N-terminal kinase (JNK) signaling pathways to regulate interommatidial bristle (IOB) formation. Previous studies have identified <em>mid</em>’s role in cell fate specification of sensory organ precursor cells in conjunction with the Notch-Delta …
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Hap46, ein vielseitiges Protein
… mit DNA und mit dem Transkriptionsfaktor c-Jun näher untersucht. Auf einer hervorstehenden Protuberanz der ATPase-Domäne von hsc70 konnten für die Bindung an Hap46 wichtige Aminosäuren identifiziert werden: Glutamin22 und Lysin25. Interaktionsregionen von hsc70 auf Hap46 wurden durch Analyse …
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Ruolo della fosfolipasi C-β1 nel differenziamento miogenico: identificazione di nuovi target nucleari
… mobility shift assays indicate that there is a c-jun binding site located in cyclin D3 promoter region specifically regulated by PLC-β1 and that c-jun binding activity is significantly increased by insulin stimulation and PLC-β1 overexpression. Moreover, mutation of c-jun/AP-1 binding site …
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RAR beta trans-repression of AP-1 transcription factor in HeLa cervical cancer cells : consequences on transcription of viral and cellular AP-1 controlled genes
… consistently reduced in HeLa RARß2 clones was c-Jun, despite ongoing gene expression. In order to understand by which mechanism c-Jun is reduced, and since the phosphorylation of c-Jun is important for protein stabilization, HeLa RARß2 clones were treated with different c-Jun-N-terminal kinase …
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Effect of nitric oxide and inflammatory mediators on axonal transport
… gezeigt werden, dass die Phosphorylierung der c-Jun- Kinase eine wichtige Funktion in diesem Prozess einnimmt. Mit Hilfe von biophysikalischen Verfahren wurde gezeigt, dass sich nach Phosphorylierung von c-Jun-Kinase das Kinesin-Motorprotein KIF5B vom Tubulin losgelöst hat. Die Ergebnisse lassen …
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The Novel Upstream Regulator of Fbxw7
… numerous oncoproteins such as Cyclin E, c-Myc, c-Jun and MCL1. The deregulation of these proteins often leads to the proliferation of cancer cells. Thus, intracellular stability and functional activity of FBXW7 is critical for regulating cancer. However, there is a gap of knowledge about the …
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Über die Beteiligung EGF-Rezeptor-vermittelter Signaltransduktionswege an den tumorpromovierenden Effekten von 2-Acetylaminofluoren, 2-Nitrosofluoren und Phenobarbital in HepG2-Zellen
… C (PKC), der Protoonkogene c-FOS und c-JUN in HepG2 Zellen bestimmt. Nur PB hemmte die Expression des EGF-R, wohingegen die PKC, c-FOS und c-JUN nicht beeinflusst wurden. 2-AAF, 2-NOF und PB wirkten konzentrationsabhängig zytotoxisch und antiproliferativ auf HepG2-Zellen. Die PKC scheint …
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A plazma XIII-as faktor hatása a vaszkuláris simaizomsejtek funkcióira
… folyamat során egyes angiogén fehérjék (Egr-1, c-Jun) expressziója fokozódik, az anti-angiogén fehérjéké, mint a thrombospondin-1 (TSP-1) csökken. Munkánk során vizsgálni kívántuk a TSP-1 fehérje aktivált FXIII kezelés hatására bekövetkező változását elkülönülten a simaizomsejtek lizátumában és az …
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The Association Between The Il-1 Pathway
… TOLLIP, IRAKs, MEKK1, MEK3, MEK6, JNK, P38, c-JUN, ECSIT, TRAF6, TAB1, TAK1, RKIP, NIK, IKKα, IKKβ, IκBα, and NF-κB.</p> <p>The individual SNP analysis proved to be interesting though inconclusive. There were some borderline significant results, such as associations of the SNPs rs16944, …
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