Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"buthionine sulfoximine (BSO)"”.
-
Tumor Cell Glutathione Metabolism: Therapeutic Implications
… GSH was by 2 methods: incubation of cells with buthionine sulfoximine (BSO), a nontoxic inhibitor of GSH synthesis, or with 1-chloro-2,4-dinitrobenzene, a substrate for GSH S-transferase. Sensitization to oxidative cytolysis correlated with GSH depletion by either method by the critera of both …
-
Phenotype-dependent regulation of the system x<sub>C</sub>- cystine/glutamate exchanger by glutathione levels in rat astrocyte primary cultures
… the depletion of intracellular GSH levels with buthionine sulfoximine (BSO, 500 μM, 24 hrs). Changes in Sx<sub>C</sub><super>-</super> activity correlated with: increases in both protein and mRNA levels of the xCT subunit of the Sx<sub>C</sub><super>-</super> heterodimer, an increase in the …
-
Phenotype-dependent regulation of the system x<sub>C</sub>- cystine/glutamate exchanger by glutathione levels in rat astrocyte primary cultures
… the depletion of intracellular GSH levels with buthionine sulfoximine (BSO, 500 μM, 24 hrs). Changes in Sx<sub>C</sub><super>-</super> activity correlated with: increases in both protein and mRNA levels of the xCT subunit of the Sx<sub>C</sub><super>-</super> heterodimer, an increase in the …
-
A comprehensive study of the impact of contrast medium on endothelial cells in vitro: validating the protective effects of n-acetylcysteine and assessing the importance of endothelin-1 and glutathione on contrast-induced nephropathy in patients with chronic kidney disease
… clearance of CM over time. Pre-treatment with buthionine sulfoximine (BSO), a selective inhibitor of glutathione (GSH) biosynthesis, was used to mimic the dysfunctional endothelial cell state of those at greatest risk of developing CIN. Initial results revealed that direct exposure of CM was …
-
TARGETING REDOX IN AGING AND ALZHEIMER'S DISEASE
… neurons across the age-span by titrating with buthionine sulfoximine (BSO), an inhibitor of the rate-limiting enzyme for GSH synthesis, γ-glutamylcysteine synthetase, subunit c (GCLC). We observed that in old age, neuron loss was more dependent on GSH depletion than ROS elevation. Remarkably, …