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Showing 1 to 20 of 35 for “"burn injury"”.
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Aging Effects on Acute Lung Inflammation After Burn Injury
… complications and death after a moderate sized burn injury is significantly higher in persons over the age of 65, while almost non-existant in young, healthy individuals. The studies outlined below use a murine model to determine the mechanisms behind the development of pulmonary complications …
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Burn injury and self-silencing: a study of women's narratives
Due to medical advances in burn care, the survival rate of individuals with serious burns has significantly increased. This has lead to a great need to focus on psychological aspects of burn injury recovery, particularly how people adapt to their changed bodies. The literature indicates that burn …
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Keratin Biomaterial Treatments For Burn Injury And Mechanisms Of Tissue Survival
Thermal burns typically display an injury pattern dictated by the transfer of the thermal energy into the skin and underlying tissues. There are often three zones of injury represented by a necrotic zone of disrupted cells and tissue, an intermediate zone of injured and dying cells, and a distant …
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Characterization and application of adipose derived stem cells following burn injury
Severe burns induce a prolonged inflammatory response in subcutaneous adipose tissue that modulates signaling in adipose-derived stem cells (ASCs), which hold potential for healing burn wounds or generating skin substitutes. Using a 60% rat scald burn model, we investigated the cellular source of …
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Effects of Burn Injury on Biological Ethanol and Ethyl Glucuronide Concentrations
… biomarker for ethanol consumption prior to burn injury. The literature does not address the possibility that ethanol or EtG concentrations are altered in fire deaths.</p><p>A Sprague Dawley rat model was employed to determine if ethanol and EtG concentrations in blood, liver, heart, and …
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Patterns, Variation and Mental Health Impact of Opioid Prescribing after Burn Injury
Burn injury is a severe trauma that can cause debilitating pain, disability and declines in mental health and overall quality of life. Opioids are the mainstay therapy for management of pain after burn injury. In light of the opioid epidemic in the United States and the increased risk of harm …
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Functional, Psychological and Community Integration Changes Over Time in Persons With Major Burn Injury
… integration status of individuals with major burn injury in order to determine the extent of changes over time and how functional and community integration status relates to emotional distress. This study was part of the North Texas Burn Model System Grant funded by the National Institute on …
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Effect of Severe Burn Injury on Body Composition and Muscle Metabolism in Pediatric Patients
Muscle wasting in burn injury is associated with increased morbidity and mortality. Burn-induced muscle cachexia is partly attributed to lack of physical activity imposed by standard of care. Moreover, evidence supports that muscle tissue is catabolized to provide amino acids necessary for wound …
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Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction
<p>Ethanol is a common factor in traumatic injury, including burn injury. Previous studies from our laboratory indicate that ethanol increases both pulmonary and gastrointestinal inflammation as well as susceptibility to infection in burn-injured mice; however, the mechanisms of these responses are …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
A burn injury represents one of the most severe forms of trauma and affects more than two million people in North America annually. Of all cases, nearly 4000 people die of complications related to the injury. A hallmark of severely burned patients is the activation of a hypermetabolic stress …
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ER Stress is Linked to the Regulation of Hepatic Gluconeogenesis and Phosphatidylinositol 3-kinase/Akt Signaling Post Burn Injury
Burn injury is a severe form of trauma that causes changes in glucose metabolism. Glucose metabolism is controlled during early burn injury but later results in stress induced diabetes. We have shown that this is due to differential regulation of the insulin signaling pathway in the liver.
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Exploring the psychological effects and emotional reactions of mothers to their children's burn injury : aiming at proposed future therapeutic intervention
Burn injuries are traumatic, destructive and painful, they usually involve long-term medical and psychological consequences. Burns, no matter how small, always leave a certain degree of scarring. When the facial area is involved, it leaves children feeling branded for life with painful …
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Effects of Acute Alcohol Exposure on Post Burn Intestinal Immunity: Role of IL-23
<p>More than one million burn injuries are reported yearly within the United States. These injuries result in approximately 500,000 emergency room visits and 40,000 hospitalizations annually. Greater than 50% of these injuries occur under the influence of alcohol/ethanol (EtOH) intoxication. Burn …
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Examination of the Burn Model Systems and the Multicenter Benchmarking Study Outcome Measures Using the International Classification of Functioning, Disability and Health
The Burn Injury Model Systems and the Multi-Center Burn Study are two nationwide, multi-center burn injury databases that use patient-reported outcome measures to collect data regarding patients’ experiences after burn injury. The data are collected in the hope that this knowledge will enable …
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School reintegration after a burn injury : a qualitative study exploring the psychosocial difficulties experienced by a group of paediatric burn survivors during the school reintegration process
Sustaining a burn injury is one of the most traumatic accidents a child or adolescent can experience. In South Africa paediatric burn injury is a significant social problem and incident rates tend to be elevated in informal settlements because of the reliance on fossil fuels (paraffin, wood, and …
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The acute effects of propranolol on metabolic dysfunction in severely burned pediatric patients
Severe burn injury is a profound and lasting form of trauma. Owing to advances over the past several decades, burn injury is no longer thought of as a mortal injury. However, significant morbidity still persists in the post-burn recovery period. Much of this morbidity is stimulated by the …
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Therapeutic Management of Burn Induced Hyperglycemia with Insulin and Metformin
Burn injury afflicts approximately 450,000 individuals annually in the United States. Despite efforts to decrease incidence via implementation of public awareness campaigns and drastic improvements in living conditions, nearly 11 million people worldwide required treatment at a major burn center or …
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Itching and Parental guilt: Parent Responses to Children's Symptoms Following Unintentional Burn Injuries
Background: Unintentional burn injury can be a traumatic and stressful event for the affected children and their parents. Young children experience persistent itching and emotional distress associated with the injury. Parents assume the responsibility to manage their child’s itching since young …
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Mechanism of Metformin Action in Dermal Fibroblasts
Burn injury is a significant problem that affects approximately half a million people in the U.S. annually. One of the major complications emerging from burn injury is hyperglycemia, which can last for weeks following the initial trauma. The primary cause of hyperglycemia is dysregulated AMPK …
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