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Showing 1 to 16 of 16 for “"bupropion"”.
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Pharmacokinetics of Bupropion and its Pharmacologically Active Metabolites in Pregnancy
Bupropion, an antidepressant and anti-smoking medication, is used for treatment of depression during pregnancy, however its efficacy as a smoking cessation aid in pregnancy has not been confirmed. The drug is extensively biotransformed by liver with the formation of pharmacologically active …
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THE EFFECTIVENESS OF BUPROPION SR ON DEPRESSIVE SYMPTOMS IN SMOKERS: SELF-REPORTS, EEG, AND INDIVIDUAL DIFFERENCES
… depressed, were randomly assigned to the Bupropion group (n = 30) or Placebo group (n = 80) in this double blind study. EEG data during the performance of a visuospatial task were collected prior to and after 14 days on bupropion or placebo capsules. It was found that bupropion …
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Comparative Effectiveness of Smoking Cessation Medications among Obese Smokers
… will be higher compared to obese smokers using bupropion during a)3, b)6, and c)12 month follow-up after treatment initiation. Objective II: To compare the post-cessation weight gain between the two FDA-approved smoking cessation medications during: a) 3 months, b) 6 months, and c) 12 months of …
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Pharmacological Chaperones of the Dopamine Transporter: A Strategy for Increasing Function of Wild Type and Mutant Transporter
… DAT ligands, we found that the DAT inhibitors bupropion and ibogaine increased DAT surface expression, whereas other inhibitors, including cocaine and methylphenidate, had no effect. The effect appears to be associated with stabilization of an inward- facing or occluded, as opposed to an …
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Dopamine Transporter (DAT), Nicotinic Acetylcholine Receptor (nAChR), and Metabotropic Glutamate Receptor 2 (mGlu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics
… lead compounds (i.e., pyrovalerone, bupropion, BINA, etc) to map their binding sites and poses within the DAT, select nAChR subtypes, or mGlu2. The central hypothesis was that these compounds could be rationally derivatized, without significant alteration in their pharmacological …
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Engineering Chemistry: Integrated Control Strategies and Internet-Enabled Tools for Chemical Synthesis
… ingredient targets: tramadol, lidocaine, bupropion and isoniazid. In the case of bupropion, the system maintained steady-state operation of a telescoped two-step process for an extended period. A researcher in Los Angeles was able to initiate and monitor all processes, via Japan, in …
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Polymer synthesis for corona phase molecular recognition based on single-walled carbon nanotubes
… Sumatriptan, Valacyclovir, Vardenafil, and Bupropion. Methacrylic acid-vinylphenylboronic acid (MA-VBA) heteropolymer and acrylic acid-styrene (AA-ST) heteropolymer were synthesized at different monomer ratios and chain lengths. These polymers were suspended with the carbon nanotubes and …
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Knowledge, attitutes and practices of medical doctors on pharmacotherapy for smoking cessation in Khomas region, Namibia
… Nicotine replacement therapy (53%) and Bupropion slow release (41%) are the most prescribed SC medications. Doctors in the private sector had better knowledge (p=0.011) and prescribed (p=0.007) SC pharmacotherapy more frequently than in the public sector. Majority 93(88%) of the doctors, …
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An evaluation and comparison of current FDA-approved treatments for obesity
… As a result, liraglutide, lorcaserin, naltrexone/bupropion extended-release, and phentermine/ topiramate extended-release became FDA-approved for long-term treatment of obesity. Each drug acts on a specific part of the CNS to modulate appetite and cause decreased food intake in patients. Clinical …
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Behavioral Intervention for Smoking Cessation in Adolescents and Young Adults
… with randomized double-blind, placebo-controlled bupropion. Of treated participants, 60.5% reduced their baseline level of smoking by half at the end of treatment; overall, treated participants reduced their smoking by 49.8%. Using intent-to-treat analyses, 7.3% of participants achieved …
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Untersuchungen zur inter- und intraindividuellen Variabilität der enzymatischen Funktion von Cytochrom P450 CYP2B6
… verglichen. Die Ergebnisse zeigten, dass Bupropion das spezifischere Substrat darstellt. Als eine Ursache der variablen Expression und Funktion dieses Enzyms waren verschiedene Mutationen im CYP2B6-Gen identifiziert worden. In Leberproben, als auch mit rekombinant exprimierten …
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Comparative Effectiveness of Smoking Cessation Medications among Schizophrenic Smokers
… include nicotine replacement therapy (NRT), Bupropion SR, and Varenicline. OBJECTIVES: To compare different pharmacotherapies in smoking cessation and to examine which medication could lead to a higher smoking abstinence rate for both short (12 weeks + 4 weeks) and long term (one year) among …
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Microarray and molecular genetic analysis of aberrant splicing in human drug metabolizing cytochromes P450 CYP2D6 and CYP2B6
… drug substrates including cyclophosphamide, bupropion and efavirenz. The common allele CYP2B6*6 [c. 516G>T, Q172H and c.785A>G, K262R] has previously been associated with lower expression in human liver and with increased plasma levels of efavirenz in HIV patients, but the molecular mechanism …
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Safety and Effectiveness of Antidepressants in Medicaid-Enrolled Pediatric Bipolar Depression
… serotonin reuptake inhibitors (SSRI) and bupropion are recommended only as adjunct therapy when 1st line treatment is ineffective (Kowatch et al., 2005). However, the utilization pattern of medications in treating bipolar depression in pediatric population is mostly unexplored. …
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Anorexigenic effects of naltrexone in rats
… NTX in combination with another molecule, bupropion, has been approved as a pharmaceutical to treat obesity. This success underscores the need for further characterization of anorexigenic potential of NTX to determine its effects in various eating behavioral contexts/scenarios, in …
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INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE "BATH SALTS" SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS
… substrate activity, similar to the cathinone bupropion. Additionally, our studies with MDPV have identified MDPV as a highly reinforcing and rewarding psychostimulant, with notable potency differences compared to cocaine. While our efforts to attenuate reinstatement of MDPV-seeking the …