Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"buprenorphine"”.
-
Emerging Patterns of Substance Use and Buprenorphine Nonadherence
… called the Trial of Adherence Application for Buprenorphine Treatment (TAAB) to evaluate the association between methamphetamine use and buprenorphine adherence among people receiving buprenorphine as treatment for OUD. Among this study population, we found a significant positive association …
-
Buprenorphine metabolism by preterm placentas: A pilot study
… the major enzyme responsible for metabolism of buprenorphine to nor-buprenorphine in human preterm placentas and to elucidate whether the development/gestational age of the placenta affects metabolism of buprenorphine. The estimated apparent Km did not appear to change with gestational age …
-
Counseling interventions with buprenorphine for treatment of opioid use disorders
… opioid use disorder (OUD) (Bart, 2012). While buprenorphine, an approved medication for the treatment of OUD, has a wide research base to support its efficacy, there is little research or guidance on behavioral interventions to use in conjunction with the medication. Investigating clients' …
-
Buprenorphine and Methadone in pregnancy: effects on the mother, fetus and neonate.
… study aimed to assess the efficacy and safety of buprenorphine maintenance for the treatment of illicit opioid dependence during pregnancy. Parameters investigated assessed pregnancy progression and Neonatal Abstinence Syndrome (NAS) compared to methadone maintenance and non-opioid exposed control …
-
Pharmacokinetics of a high-concentration formulation of buprenorphine (Simbadol®) in male dogs
Objective: To describe the pharmacokinetics of buprenorphine in dogs following administration of a high-concentration formulation of buprenorphine. Study design: Prospective, randomized, crossover study. Animals: A total of six healthy male intact Beagle dogs, 9–13 months of age and weighing 10.3 ± …
-
Induction of transdermal buprenorphine (Butrans®) to extended-release buprenorphine subcutaneous injection (Sublocade®) for opioid use disorder: a case series & a qualitative study on the experiences, barriers, and understanding of opioid agonist treatment among youth with opioid use disorder in Vancouver, British Columbia
… of opioid agonist treatment, including buprenorphine and methadone, is a complex and crucial step in care for those beginning pharmacological treatment, as well as those transitioning between medications, as poor treatment retention is largely attributed to discomfort during the …
-
Agreement between self-report and urine drug test results in a sample patients treated with buprenorphine for opioid use disorder
… patients treated for opioid use disorder with buprenorphine. Whether UDT data contributes clinically useful information beyond patient self-report of drug use has received minimal attention. It is unclear whether differences between patient self-report and UDT results varies with time in …
-
OPIOID ADDICTION AND PREGNANCY: POTENTIAL EFFECTS OF SUBSTITUTION THERAPIES ON DEVELOPMENTAL MYELINATION
… therapies in pregnant opioid addicts include buprenorphine, a mu opioid receptor partial agonist and kappa opioid receptor antagonist. However, while clinical studies demonstrated buprenorphine efficacy in reducing neonatal withdrawal symptoms, there is a lack of information on the potential …
-
Opioid Addiction Treatments During Pregnancy and Their Effects on Axonal Growth and Myelination in the Developing Central Nervous System
Treatment with buprenorphine represents a promising alternative for pregnant opioid addicts but there is a need to understand potential effects on nervous system development. We previously showed effects of perinatal exposure to buprenorphine on axonal caliber and myelination in 26-day-old rat …
-
Personality and attention bias in adults with a history of childhood trauma, and attenuating effects of mu-opioid agonist buprenorphine on attention bias
… the possible effects of the mu-opioid agonist buprenorphine on attentional bias in the Trauma group.
-
Enhancing the use of opioids in pain management: antinociceptive potentiation with opioid agonist/antagonist combinations.
… of the partial opioid agonist/antagonist buprenorphine and ultra-low doses of the antagonist naloxone. The central aim of the studies described herein was to investigate the effect of this drug combination on response to experimental nociceptive stimuli and the incidence and severity of …
-
The impact of regulatory changes on the providers of treatment for opioid dependence
… waivers to use narcotic medications, such as buprenorphine, for treatment of opioid dependence. As of 2006, physicians have been allowed to treat up to 100 patients after spending one year at a 30-patient limit. Physicians may choose to discontinue use of buprenorphine after the patient has …
-
Investigations of the neurobiological and behavioural actions of cocaine
… neurochemical interactions between cocaine and buprenorphine were examined using a conditioned place preference (CPP) procedure and in vivo microdialysis. Cocaine and buprenorphine both elicited CPP; moreover, these drugs interacted to produce significantly larger CPPs when given in combination. …
-
Development of the Sustained Release Analgesic Formulations for Rodents and a Novel In Vitro Model for Parenteral Formulations with the Character of a Level A IVIVC
… A survey of current literature indicates that buprenorphine is the most widely used narcotic analgesic for rodents because of its excellent analgesic activity and long duration of action. The Formulary for Laboratory Animals lists the buprenorphine dose for rats as 0.05 mg/kg (SC, tid, qid). …
-
Patient Perspectives, Follow-up Patterns, and Cost-Effectiveness of a Low-Threshold Mobile Medical Unit
… accessing medication therapy for OUD, including buprenorphine. Low-threshold approaches to delivering medication for OUD, such as mobile medical units, acknowledge and address these barriers by meeting individuals where they are. The services provided, populations served, and implementation …
-
Applications of LC-MS/MS in forensic toxicology for the analysis of drugs and their metabolites
… methods for opioid analysis were compared for buprenorphine (BUP) analysis. The aims were to develop and validate a method for the direct determination (DM) of buprenorphine (BUP), norbuprenorphine (NBUB), buprenorphine-3-glucuronide (B3G) and norbuprenorphine-3-glucuronide (NBUP3G). This …
-
Two methods of biomarker discovery: applications in neuropathic pain and pharmacotherapy.
… day-to-day effects of alternate-daily-dosed buprenorphine and the combination of buprenorphine on the dosing day with sleep deprivation. Psychomotor impairment was measured using saccadic eye movements, other oculomotor measures and an alertness visual analogue scale (VAS). Saccadic eye …
-
Management of treatment resistant depression /
… treatments such as ketamine, psilocybin, buprenorphine, and dextromethorphan and non-pharmacological interventions, encompassing psychotherapeutic methods and brain stimulation techniques like electroconvulsive therapy and repetitive transcranial magnetic stimulation, can be considered …
-
OPPOSING ROLES OF THE μ-OPIOID AND NOCICEPTIN/ORPHANIN FQ RECEPTORS IN OLIGODENDROCYTE DEVELOPMENT AND MYELINATION
… myelination is altered by perinatal exposure to buprenorphine, an opioid analogue in clinical trials for the treatment of pregnant opioid addicts. We now found that the in vivo effects on myelination could result from direct alteration in the balance between μ-opioid receptor (MOR) and …
-
Study of SERS for the detection of drugs of abuse
… analysis. Successful detection of methadone and buprenorphine, used to treat heroin addiction, was achieved with Ag/Ti0₂ substrates at concentrations associated with therapeutic use, representing lower concentration drugs. The detection of MDMA in oral fluid following ecstasy use, not only showed …
Page 1 of 2