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Showing 1 to 2 of 2 for “"bump-hole"”.
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Histone Deacetylase 1: Mutagenesis And Small Molecule Studies
… goal, we did extensive studies to create a HDAC1 bump-hole inhibitors pair as an alternative to genetic methods which are limited in their usage to characterize HDAC1 function. We developed and validated a histone deacetylase dependent screen in the yeast Rpd3 protein. Using this screen screened a …
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Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase
Acetylcholinesterase (AChE) terminates cholinergic neurotransmission by catalyzing the hydrolysis of the neurotransmitter acetylcholine (ACh). Inhibition of AChE has proven an effective treatment for the memory loss exhibited by early stage Alzheimer's disease (AD) patients; four AChE inhibitors …