Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"building block synthesis"”.
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NATURAL PRODUCT AND BUILDING BLOCK SYNTHESIS: CAROLACTON-INSPIRED ANALOGS, THE ANTITUMOR THERAPEUTIC FRAX-1036, AND THE CONSTRUCTION OF ATOMICALLY PRECISE MEMBRANES FROM SPIROLIGOMERS
… approach are also described. The first, the synthesis of the antitumor compound FRAX-1036, was completed as part of a collaboration with the Chernoff group at Fox Chase Cancer Center to provide them with more material for murine testing. The second, the synthesis of macrocycles for the …
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Concept synthesis and design optimization of meso-scale, multi-degree-of-freedom precision flexure motion systems with integrated strain-based sensors
… tools for flexure system and compliant mechanism synthesis are not capable of simultaneously optimizing the mechanical and sensing subsystems. The building block synthesis approach developed in this work is the only tool capable of designing compliant mechanisms with integrated strain based …
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Development of algorithmically prioritized methods for generalized natural product synthesis
The synthesis of small molecule natural products has long captivated the attention of chemists and has generally proceeded via custom solutions to specific molecules. We propose to instead utilize a human guided algorithm to analyze a building block approach to natural products and identify key …
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Kinetic and structural evolution of functional peptide assembling networks
… peptide assemblies. First, the crucial building blocks capable of assembly are synthesized and selected via the dynamic combinatorial networks (DCNs), which yield sequence-defined oligomers with high fidelity. Both experimental analyses and mathematical modeling are applied to confirm …
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The Development of Computational High-Throughput Approaches for Screening Metal-Organic Frameworks in Adsorptive Separation Applications
… purposes as their diversity, due to their building block synthesis from metal clusters and organic linker, gives rise to a wide range of porous structures. Engineering of a separation process is a multi-disciplinary problem that requires a holistic approach. In particular, material …