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Showing 1 to 18 of 18 for “"budesonide"”.
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Engineering of Inhalation Aerosols Combining Theophylline and Budesonide
In asthma therapy, the use of theophylline to prevent bronchial spasm and glucocorticoids to decrease inflammation is widely indicated. Apart from the acute asthma attack oral theophylline is treated for chronic therapy in order to minimize inflammation and to enhance the efficiency of …
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Development of dry powder Inhaler and nebulised nanoparticles formulations of chrysin for the potential treatment of asthma. Development of dry powder inhaler of chrysin and nebulised nanoemulsion combination of chrysin and budesonide; Evaluating the anti-inflammatory activity of the combination formulation of chrysin and budesonide for asthma
… of combined formulations of chrysin and budesonide. Dry powder inhaler formulations were used first, where chrysin was processed using three different techniques, namely ball-milling, sonocrystallisation, and spray drying, to obtain a suitable particle size for inhalation. The highest …
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Performance of two different types of inhalers. Influence of flow and spacer on emitted dose and aerodynamic characterisation.
… of three mainstream inhaled drugs Formoterol, Budesonide and Beclomethasone for treatment of asthma and COPD. The areas investigated are these which have been raised in reports and studies, where there are concern, for drug use and assessment of their use. In reporting this work the literature …
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Investigation to Identify the Influence of the Surface Energetics of the Dry Powder Formulations of Budesonide and Theophylline on Their Aerodynamic Dose Emission Characteristics.
… energies of a set of single drug and carrier (budesonide or theophylline with either mannitol or lactose) with different levels of surfactant using Inverse Gas Chromatography, and comparing them to their lung deposition performance using a Next Generation Impactor established a relationship …
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Investigation to Identify the Influence of Mannitol as a Carrier on the Ex-Vivo Dose Emission and the In-Vitro Aerodynamic Dose Emission Characteristics of Dry Powder Inhalers of Budesonide
… vivo comparative evaluation of formulations of budesonide with crystallised β-form mannitol, commercial DPI grade mannitol and lactose. The lactose-budesonide was the marketed Easyhaler® 200 g formulation. Ex vivo assessment of deposition using the Easyhaler® multi-dose high resistance inhaler …
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Evaluating the use of cross-linked PVA nanoparticles for gene and drug delivery
… a cross-linked PVA nanoparticle containing budesonide, achieved higher levels of drug delivery than a commercially available form of the same drug (Pulmicort®) after 1 or 24 hours drug exposure. Furthermore, by measuring superoxide production during a stimulated respiratory burst, the …
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Eficacia de nebulizar con adrenalina frente a budesónida en el paciente con laringotraqueobronquitis, Instituto Salvadoreño del Seguro Social, San Miguel. año 2019
… efficacy of nebulization with Adrenaline versus Budesonide in patients with laryngotracheobronchitis, attended at the Salvadoran Institute of Social Security. The methodology used was prospective, cross-sectional, descriptive and analytical. The choice of patients to carry out this study were …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
… three steroids (hydrocortisone, prednisolone and budesonide). Arrested antisolvent nanoprecipitation using ethanol (solvent) and water (antisolvent) was conducted within the microreactors. To enable experimental design for the microreactor studies, solubility profiles in different ethanol-water …
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Clinical, Diagnostic, Therapeutic and Prognostic Aspects of Autoimmune Liver Diseases /// Клинико-диагностични, терапевтични и прогностични аспекти на автоимунните чернодробни болести
… при пациенти с ПБХ. Потвърдена е ролята на Budesonide за постигане и поддържане на ремисия при пациентите с АИХ. Оценен е биохимичният отговор и дългосрочна прогноза на пациентите с ПБХ. Проведен е сравнителен анализ на стойностите на IgG на лица с АИХ, хронични чернодробни заболявания и …
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Spray Techniques And Lung Cancer Chemoprevention
… with high dosages. The effect of aerosolized budesonide was studied. It was further combined with diet Polyphenon E, diet indole-3-carbinal, or oral pioglitazone in the animal study for the inhibitory effects over lung carcinogenesis. Aerosol characterization and drug concentration in …
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The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical Ingredients; Bespoke Analytical Method Development Leading to Novel Formulation Approaches for Product Development.
… methods have been developed and validated using budesonide to provide limits of determination as low as 1 μg/mL and extended to 11 IPPs chosen to represent currently prescribed inhaled corticosteroids (ICS), β2-adrenoagonists and antimuscarinic bronchodilators, and have highlighted solubility …
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Vibrational spectroscopic techniques (Raman, FT-IR and FT-NIR spectroscopy) as a means for the solid-state structural analysis of pharmaceuticals
… structural analysis of pharmaceuticals. Budesonide, fluticasone propionate, salbutamol hemisulfate, terbutaline hemisulfate, ipratropium bromide, polymorphic forms of salmeterol xinafoate and two polymorphic forms of sulfathiazole were selected since they are used in the management of …
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Rhinomanometry in clinical use. A tool in the septoplasty decision making process.
… to normal. Intervention with topical budesonide treatment during a new five month period reduced both NAR and it’s variability significantly.
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Engineering of Amorphous Active Pharmaceutical Ingredients by Sonoprecipitation and Spray Drying Pre-and Post-Processing Pharmaceutical Characterisation. Pre- and Post-Processing Physicochemical and Micromeritic Characterisation of Active Pharmaceutical Ingredients
… and evaporative antisolvent sonoprecipitation. Budesonide (BUD) and simvastatin (SMV) were used as model poorly soluble APIs. Amorphous phases of relatively low-glass transition (Tg) APIs are physically unstable and crystallise upon storage and/or processing conditions. To tackle this issue, for …
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A microparticle engineering approach to enhance the potency of mesenchymal stem cells
… particles containing the glucocorticoid steroid, budesonide, doubled their potency in suppressing activated peripheral blood mononuclear cell co-cultures in an IDO dependent manner. While the platform presented here was used to control, track, and augment MSCs, it can easily be tailored to control …
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Analysis of the Repeated Measurement Data using the Hierarchical Clustering and Nonlinear Regression Methods in Asthma Pharmacogenetic Study
… were enrolled. With using combination inhaler (budesonide/formoterol 320μg/d) for 80 days, we monitored morning and evening peak expiratory flow daily and pulmonary function every 8 weeks. Twelve SNPs from 9 candidate genes including ADCY9 132007 T>C (Ile772Met), ALOX5 -1708 G>A, CysLTR1 -634 …
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Novel Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signalling
… human Smo CRD interact with the glucocorticoid: Budesonide (Bud), albeit with different binding affinities. We identified the key residues in both species that are important for this interaction and generated the complex structure of the Drosophila Smo CRD with Bud using computational …
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Chemoprevention of Lung Carcinogenesis: Aerosol Administration and Deposition in the Mouse Lung
… anthocyanins. The combinations of aerosolized budesonide: a synthetic glucocorticoid) and dietary polyphenon E: a well-defined mixture of green tea extract) was discussed as one example of the combinational treatment.</p><p>In addition to the bioassays, drug deposition in the mouse lung was …