Global ETD Search
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Showing 1 to 3 of 3 for “"budding yeast model"”.
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Computational Software for Building Biochemical Reaction Network Models with Differential Equations
… physiology requires accurate mathematical models that depict the temporal dynamics of these chemical processes. Modelers build mathematical models of chemical processes primarily from systems of differential equations. Although developing new biological ideas is more of an art than a …
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Nanobody-Based Interactomic Studies of Single Transcripts During mRNA Maturation
… targeted isolations of mRNPs, starting in a budding yeast model system. In our approach, a single target transcript is tagged with MS2 hairpin sequences – these hairpins are bound specifically and with high affinity by the bacteriophage MS2 coat protein (MS2CP). In the first purification …
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Functions of RNA exosome and tRNA splicing ligase in Mendelian and Infectious diseases
… unknown.</p> <p>Here, I developed a hybrid yeast/mammalian RNA exosome model of exosomopathies by systematically replacing the individual yeast subunits with their corresponding human or mouse orthologs. This allows us to unambiguously assess the damaging effects of the exact patient variant …