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Showing 1 to 11 of 11 for “"budding yeast cell cycle"”.
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Visualization of the Budding Yeast Cell Cycle
The cell cycle of budding yeast is controlled by a complex chemically reacting network of a large group of species, including mRNAs and proteins. Many mathematical models have been proposed to unravel its molecular mechanism. However, it is hard for people with less training to visually interpret …
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Mathematical Modeling of the Budding Yeast Cell Cycle
The cell cycle of the budding yeast, Saccharomyces cerevisiae, is regulated by a complex network of chemical reactions controlling the activity of the cyclin-dependent kinases (CDKs), a family of protein kinases that drive the major events of the cell cycle. A previous mathematical model by Chen et …
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Budding yeast cell cycle analysis and morphological characterization by automated image analysis
Budding yeast Saccharomyces cerevisiae is a standard model system for analyzing cellular response as it is related to the cell cycle. The analysis of yeast cell cycle is typically done visually or by using flow cytometry. The first of these methods is slow, while the second offers a limited amount …
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Temporal organization of the budding yeast cell cycle: general principles and detailed simulations
The budding yeast cell cycle has attracted attention from many experimentalists over the years for its simplicity and amenability to genetic manipulation. Moreover, the regulatory components described in budding yeast, Saccharomyces cerevisiae, are conserved in higher eukaryotes. The budding yeast …
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Deterministic Parallel Global Parameter Estimation for a Model of the Budding Yeast Cell Cycle
… differential equations designed to simulate the cell cycle of budding yeast. Comparing the model simulation results to experimental data is difficult because most of the experimental data is qualitative rather than quantitative. An algorithm to convert simulation results to mutant phenotypes is …
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Mathematical modeling approaches for dynamical analysis of protein regulatory networks with applications to the budding yeast cell cycle and the circadian rhythm in cyanobacteria
… we demonstrate its utility by applying it to the budding yeast cell cycle. To confront the second challenge, modelers have developed rule-based modeling as a framework to build complex mathematical models. In this approach, the modeler describes a set of rules that instructs the computer to …
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Analysis and Application of Haseltine and Rawlings's Hybrid Stochastic Simulation Algorithm
Stochastic effects in cellular systems are usually modeled and simulated with Gillespie's stochastic simulation algorithm (SSA), which follows the same theoretical derivation as the chemical master equation (CME), but the low efficiency of SSA limits its application to large chemical networks. To …
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Power Saving Analysis and Experiments for Large Scale Global Optimization
… biology application, parameter estimation for a budding yeast cell cycle model, on System G. Two power aware approaches for pVTdirect are developed and compared against the CPUSPEED power saving system tool. The results show that knowledge of the parallel workload of the underlying application is …
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Mathematical modeling of pathways involved in cell cycle regulation and differentiation
Cellular processes critical to sustaining physiology, including growth, division and differentiation, are carefully governed by intricate control systems. Deregulations in these systems often result in complex diseases such as cancer. Hence, it is crucial to understand the interactions between …
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Stochastic Modeling and Simulation of Multiscale Biochemical Systems
… and proteins and their dynamics in a single cell, which calls for quantitative stochastic models for gene and protein networks at cellular levels that match well with the data and account for cellular noise. This dissertation studies a stochastic spatiotemporal model of the Caulobacter …
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Cell Size Control And Asymmetric Cell Fates In Start Of The Saccharomyces cerevisiae Cell Cycle
… mechanisms that couple the process of cell growth to cell division is one of the major challenges of modern cell biology. Saccharomyces cerevisiae (budding yeast) has been an important model organism to study the coupling between cell growth and cell division. The insights obtained from …