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Showing 1 to 20 of 51 for “"brucellosis"”.
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Brucellosis in Ethiopia: epidemiology and public health significance.
ABSTRACT Brucellosis is a common bacterial zoonotic disease that has important veterinary and public health concerns and economic impact in Sub-Saharan Africa including Ethiopia. A cross-sectional study was conducted in Addis Ababa Dairy farms and four selected districts of Borena Pastoral setting …
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Immunocontraceptive vaccines against brucellosis and population growth in feral swine
… are known carriers of zoonotic diseases such as brucellosis, which threatens both livestock biosecurity and public health. Recombinant multimeric gonadotropin-releasing hormone (mGnRH) has been previously used as a subunit vaccine to induce immunocontraception in feral pigs. However, potent …
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Approaches towards therapeutic development against chronic brucellosis in a mouse model
Brucellosis is the most common zoonotic disease worldwide. The intracellular localization of Brucella hinders the action of drugs that poorly cross cell membrane barriers. Additionally, when the immune response fails to clear the infection, chronic brucellosis ensues that becomes more challenging …
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NOVEL STRATEGIES TO DEVELOP BETTER BRUCELLOSIS VACCINES USING BRUCELLA ABORTUS RB51 AND B. NEOTOMAE
… is used as a licensed live vaccine for bovine brucellosis in the United States and several other countries. Previous studies have shown that the wboA gene, which encodes a glycosyltransferase required for the synthesis of O-polysaccharide in Brucella, is disrupted in B. abortus RB51 by an IS711 …
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Development of Brucella abortus RB51 as a Vaccine to Protect Against Brucellosis and Anthrax
… are crucial in affording protection against brucellosis. B. abortus strain RB51 has been shown to be useful in eliciting protective CMI and antibody responses against Brucella in cattle and other animal species. Since the protective antigen (PA) of B. anthracis is known to induce antibodies, …
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Development of an Antibiotic Resistance Free Bivalent Vaccine Against Swine Brucellosis and Swine Influenza
… of both bacterial and viral origin. Swine brucellosis caused by Brucella suis and swine influenza caused by Influenza A virus affect both domestic and feral swine populations. Both the diseases have zoonotic potential to cause disease in humans with serious complications apart from …
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BRUCELLOSIS TRANSMISSION BETWEEN WILDLIFE AND LIVESTOCK IN THE GREATER YELLOWSTONE ECOSYSTEM: INFERENCES FROM DNA GENOTYPING
Brucellosis transmission between wildlife species and cattle in the greater Yellowstone ecosystem has been difficult to assess because the causative agent Brucella abortus bacteria is extremely difficult to isolate for DNA genotyping. We examined transmission of B. abortus between bison, elk, and …
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BRUCELLOSIS TRANSMISSION BETWEEN WILDLIFE AND LIVESTOCK IN THE GREATER YELLOWSTONE ECOSYSTEM: INFERENCES FROM DNA GENOTYPING
Brucellosis transmission between wildlife species and cattle in the greater Yellowstone ecosystem has been difficult to assess because the causative agent Brucella abortus bacteria is extremely difficult to isolate for DNA genotyping. We examined transmission of B. abortus between bison, elk, and …
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Immune mechanisms in murine brucellosis: studies with strain RB51, a rough mutant of Brucella abortus
… and cell mediated immune responses in murine brucellosis were investigated in this study.B. abortus strain 19, the current vaccine strain, is known to induce an antibody as well as cell mediated immune responses, both of which protect mice against smooth strain 2308. B. abortus rough strain …
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Brucella abortus Strain RB51 Outer Membrane Vesicles as a Vaccine Against Brucellosis in a Murine Model
… agent that primarily infects cattle and causes brucellosis. B. abortus strain RB51 is a live, attenuated vaccine licensed for cattle. However, there is no available vaccine to prevent human brucellosis. Outer membrane vesicles have been tested as potential vaccines to prevent diseases caused by …
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Impact of brucellosis on Socio-Economic Well-being of Cattle Farmers inthe Western and Southern Provinces of Zambia
Brucellosis is a highly contagious zoonotic and devastating disease that affects households‟ potential to improve their well-being through trade in livestock and livestock commodities. Despite the disease being endemic in Zambia, there is inadequate information, on its socio-economic impact on the …
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Impact of brucellosis on Socio-Economic Well-being of Cattle Farmers inthe Western and Southern Provinces of Zambia
Brucellosis is a highly contagious zoonotic and devastating disease that affects households‟ potential to improve their well-being through trade in livestock and livestock commodities. Despite the disease being endemic in Zambia, there is inadequate information, on its socio-economic impact on the …
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The pregnant mouse model of brucellosis: the pathology and protection studies comparing Brucella abortus strains 2308, 19 and RB51
Brucellosis caused by Brucella abortus is an important zoonotic disease characterized in cattle by placentitis, fetal death and abortion. Brucellosis research employing the pregnant mouse model has been limited to the bacteriology and immunology of the disease. Studies reported in this dissertation …
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Rough leucine auxotrophic strains of <i>Brucella</i> expressing <i>Salmonella</i> flagellin C conjugated gonadotropins, an immunocontraceptive brucellosis vaccine for feral swine population control
Brucellosis, caused by Gram-negative bacteria of the genus <i>Brucella</i>, is a zoonotic disease with global impacts on human, livestock, and wildlife health. Around 500,000 cases of human brucellosis are reported by the World Health Organization annually. Even though brucellosis has been …
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Induction of Protection, Antibodies and Cell Mediated Immune Responses by Brucella Abortus Strain RB51, Ochrobactrum Anthropi and Recombinants Thereof
… (CMI) plays a key role in protection against brucellosis, the exact immune mechanisms leading to protection are still not fully understood. Better understanding of the mechanisms would help in the development of a human Brucella vaccine and help in improving animal vaccines. In this research, …
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Mathematical models of immune responses following vaccination with application to Brucella infection
For many years bovine brucellosis was a zoonosis endemic in large parts of the world. While it is still endemic in some parts, such as the Middle East or India, several countries such as Australia and Canada have successfully eradicated brucellosis in cattle by applying vaccines, improving the …
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Seroprevalence and characterization of Brucella SPP. isolated from humans and cattle in Southern and Western provinces of Zambia..
Brucellosis is one of the top seven neglected zoonoses endemic in livestock and humans in developing countries including Zambia. A cross-sectional study was conducted between May 2017 and August 2021 in Zambia in the Southern province in Choma, Monze and Namwala and in the Western province in Mongu …
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Seroprevalence and characterization of Brucella SPP. isolated from humans and cattle in Southern and Western provinces of Zambia..
Brucellosis is one of the top seven neglected zoonoses endemic in livestock and humans in developing countries including Zambia. A cross-sectional study was conducted between May 2017 and August 2021 in Zambia in the Southern province in Choma, Monze and Namwala and in the Western province in Mongu …
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