Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"brown fat"”.
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Immunological, vascular and metabolic actions of androgens
… atherosclerosis, abdominal aortic aneurysms and brown fat activity in male mice. The main findings were that androgens/AR: 1) control splenic B cell numbers via nervous regulation of splenic stroma and the cytokine BAFF, 2) protect against atherosclerosis in a T cell-dependent manner and that …
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Modulation of lineage-specific cell differentiation by long non-coding RNAs
… identified ~1500 lncRNAs. These included many brown fat-specific loci induced during differentiation which are targets of key adipogenic factors. Inhibiting one of them, lnc-BATE1, compromised brown adipocyte development, impairing activation of brown fat genes, mitochondrial biogenesis, and …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… type 2 diabetes, cardiovascular disease, fatty liver diseases and other human disease like female infertility, mental depression and even certain types of cancer. Obesity, characterized by excessive body weight, is often considered to result from an imbalance between energy intake and …
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AQP1—A REGULATORY FACTOR ASSOCIATED WITH BROWN ADIPOSE TISSUE SILENCING TO COMBAT OBESITY AND METABOLIC DISEASE
… of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) by environmental cold challenge yields strong metabolic benefit in the face of diet-induced obesity (DIO). Yet, a critical barrier to leveraging brown fat NST for therapeutic use against metabolic disease is that BAT is …
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Mapping And Directing Branched-Chain Amino Acid Metabolism In Health And Insulin Resistance
… BCAA oxidation occurs in skeletal muscle, brown fat, and liver. Genetic and pharmacologic suppression of branched-chain alpha-ketoacid dehydrogenase kinase, a regulatory kinase, induces BCAA oxidation primarily in skeletal muscle of healthy mice. While insulin acutely increases BCAA …
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Adrenergic control of proteolysis in brown adipocytes
Brown adipose tissue (BAT) is a sympathetically innervated tissue involved in control of thermoregulation and energy balance. BAT growth and/or atrophy occur in response to the need for energy dissipation. Fasting, deacclimation, and lactation result in tissue atrophy by loss of cells, …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… adipose depots, white adipose tissue (WAT) and brown adipose tissue (BAT) that carry out essentially opposite functions. WAT is primarily involved in storing excess energy, whereas BAT burns excess energy in the form heat. This fat burning aspect of BAT has emerged as a powerful tool in …
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pRb's role in cell fate, lineage commitment, and tumorigenesis
… presence of Rb, while Rb loss strongly favored brown fat tumors. Thus, to directly address the influence of Rb status in mesenchymal tumorigenesis we used inducible systems to control pRB's expression. Our data showed that toggling between Rb loss or Rb re-activation was sufficient to switch the …
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Fatty Acid Fate In Determining Oxidation And Inflammation In Adipose Tissue
… through its ability to store or oxidize free fatty acids (FFAs). White adipose tissue (WAT) functions as an anabolic organ to sequester and release FAs, in contrast brown adipose tissue (BAT) is a catabolic organ that oxidizes FAs. However, a comprehensive understanding of the role that FFAs …
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EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… of hyperinsulinemia, elevated circulating free fatty acids and triglycerides, hyperglycemia, and the activation of systemic immune system during the development of T2DM. In skeletal muscle, loss of mitochondrial function is evident in some insulin-resistant subjects years before they develop …