Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"brown adipose tissue"”.
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The role of extracellular matrix remodelling in brown adipose tissue functions: New candidates
Brown adipose tissue (BAT) is specialised in energy expenditure, as it has the capacity to perform thermogenesis, which consists on dissipating energy by producing heat to maintain body temperature from the oxidation of lipids, primarily, upon norepinephrine stimulation. BAT can improve …
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The role of brown adipose tissue on substrate metabolism and insulin sensitivity in humans
Brown adipose tissue (BAT) is a recently re-discovered tissue in humans. The role of BAT in thermogenesis and metabolic regulation has been established in rodents. However, the physiological and clinical significance of this tissue in humans has not been proven yet. The purpose of these …
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AQP1—A REGULATORY FACTOR ASSOCIATED WITH BROWN ADIPOSE TISSUE SILENCING TO COMBAT OBESITY AND METABOLIC DISEASE
… of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) by environmental cold challenge yields strong metabolic benefit in the face of diet-induced obesity (DIO). Yet, a critical barrier to leveraging brown fat NST for therapeutic use against metabolic disease is that BAT is …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… response in burns is the role of the adipose tissue. Humans harbour two distinct adipose depots, white adipose tissue (WAT) and brown adipose tissue (BAT) that carry out essentially opposite functions. WAT is primarily involved in storing excess energy, whereas BAT burns excess energy …
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Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, <i>Ictidomys tridecemlineatus</i>.
Brown adipose tissue (BAT) is the major thermogenic tissue in small eutherian mammals. In hibernators, seasonal modifications of BAT are well documented but little is known about its functional regulation during hibernation. BAT metabolism is activated by sympathetic stimulation, so I hypothesized …
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The effect of exercise training on energy balance in the laboratory rat
… oxygen consumption. A reduction in interscapular brown adipose tissue cytochrome oxidase activity in the spontaneous wheel exercise - trained rats suggested that brown adipose tissue regulatory thermogenesis may have been depressed. Down regulation of brown adipose tissue -adrenoreceptors was not …
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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
… induction of uncoupling protein 1 (UCP1) in the brown adipose tissue (BAT) of IIA+ mice, suggesting enhanced mitochondrial uncoupling in their adipose tissue to drive this metabolic phenotype. Previous work in Dr. Park’s laboratory suggested that hepatic PLA2G2A expression is negatively regulated …
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Evidence for the autocrine/paracrine regulation of tissue growth by the insulin-like growth factors
Many tissues can undergo tissue specific (local) growth in response to various stimuli. The objectives of this thesis were to investigate the local growth of skeletal muscle and brown adipose tissue and the possible involvement of the insulin-like growth factors (IGF-I and IGF-II) in regulating …
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Cold-Induced Metabolic Changes in Lean, NAG-1 Transgenic Mice
… for addressing genetic factors is activating brown adipose tissue which increases thermogenesis, the process of burning stored fats to generate heat. Cold exposure is a known way to activate brown adipose tissue through b3-adrenergic signaling. This signaling pathway causes an upregulation of …
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Role of Tyk2 in the Development of Beige Cells
Obesity results from an excess of adipose tissue and is a major risk factor for type 2 diabetes, cardiovascular disease, and cancer. Adipose tissue exists in two main forms: white adipose tissue (WAT), which stores energy as triglycerides, and brown adipose tissue (BAT), which dissipates stored …
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Dissecting NAMPT Signaling Pathways in Beige Adipocyte Development, Impairment and Maintenance
Obesity and aging remodel adipose tissue in ways that reduce the abundance and function of thermogenic beige and brown adipocytes, lowering energy expenditure and worsening metabolic disease. Beige adipocytes arise within white adipose tissue in response to environmental and hormonal cues, whereas …
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Exploring the Importance of PREX Proteins in Glucose Homeostasis and Insulin Signalling
… Prex proteins are expressed in brain, liver and brown adipose tissue, whereas Prex1 is also expressed white adipose tissue. Prex1 deficient mice had small livers, with reduced glycogen storage, eosinophilia in brown adipose tissue and reduced fasting plasma levels of adiponectin. Surprisingly, …
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The role of beta3-adrenergic receptors in control of brown and white adipose tissues and of energy balance: Reversal of obesity by CL 316,243, a new beta3-adrenergic agonist.
… drugs is the $\beta$3-adrenergic receptor in brown and white adipose tissues. Selective $\beta$3-adrenergic receptor agonists have been developed that will stimulate both the mobilization of fat from white adipose tissue, the site of triacylglycerol storage in the body, and the oxidation of …
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The mode of action of a lipid mobilising factor in cancer cachexia
… due to depletion of both skeletal muscle and adipose tissue. The loss of adipose tissue is due to the production of a tumour-derived lipid mobilising factor (LMF), which has been shown to directly induce lipolysis in isolated epididymal murine white adipocytes. The administration of LMF to a …
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Investigation and validation of mammalian telomeres as biomarkers for health and disease
… on the effects of DNA extraction methodology, tissue-specific telomere dynamics, and telomere-specific oxidative damage. A mouse adapted monochromatic multiplex qPCR (mmqPCR) assay was developed and validated to measure relative TL, complemented by a formamidopyrimidine DNA glycosylase (FPG) …
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Adrenergic control of proteolysis in brown adipocytes
Brown adipose tissue (BAT) is a sympathetically innervated tissue involved in control of thermoregulation and energy balance. BAT growth and/or atrophy occur in response to the need for energy dissipation. Fasting, deacclimation, and lactation result in tissue atrophy by loss of cells, …
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Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
… vital role in regulating energy homeostasis and adipose tissue metabolism. It has been demonstrated that ERα is abundantly expressed in the ventrolateral region of the ventromedial hypothalamus (vlVMH), a sex-dimorphic structure that directly modulates brown adipose tissue (BAT) thermogenesis. We …
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The Role of Thada in Energy Homeostasis
… under specific environmental conditions when the brown adipose tissue (BAT) is cancelled/neutralised. Our physiological data are supported by a robust transcriptomic signature where skeletal muscle, BAT and inguinal subcutaneous white adipose tissue of the Thada KO mice presented primary and …
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Novel Roles of GLP-1 and GLP-2 in the Regulation of Hepatic Lipid/Lipoprotein Homeostasis and the Involvement of BAT Activation
… actions respectively. Furthermore, activation of brown adipose tissue (BAT) through the sympathetic nervous system also displays hypolipidemic actions and has recently been shown to be activated by GLP-1. We hypothesized that GLP-1 and GLP-2 will play opposing roles by decreasing and increasing …
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