Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"bronchodilators"”.
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Comparison of Two Aerosolized Bronchodilators in the Treatment of Severe Equine Chronic Obstructive Pulmonary Disease
… of sympathomimetic and parasympatholytic bronchodilators for relief of acute airway obstruction and improvement of pulmonary gas exchange was compared in 6 horses with COPD. Physical examination, arterial and venous blood gas analysis and measurement of end-tidal CO₂ tension were performed …
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Regulation of cAMP-Dependent Gene Expression in Airway Epithelial Cells: A Transcriptional and Pharmacodynamic Analysis
… focus on providing symptomatic relief, with bronchodilators, and gaining disease control by suppressing inflammation. Long-acting β2-adrenoceptor agonists (LABAs) are effective bronchodilators that work by elevating cAMP in airway smooth muscle (ASM). Less appreciated and understood is the …
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Heart failure and chronic obstructive pulmonary disease: common partners, common problems
… risk associated with COPD may be attributable to bronchodilators. The prognosis of patients with HF prescribed bronchodilators is however ill defined. I examined the prognostic implications of bronchodilator use in patients with HF enrolled in the Candesartan in Heart failure Assessment of …
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Cоx-2 inhibitоrѕ in Оeѕоphаgeаl Cаncer
… to induce malignant transformation in cells. Bronchodilators and Calcium channel blockers (CCB's) that relax the Lower oesophageal sphincter (LOS) may increase Gastro-Oesophageal reflux (GORD) and the risk of Oesophageal adenocarcinoma (OAC). Hence I carried out a case control study looking …
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A Bronchiolitis Study: The Overuse of Bronchiolitis Therapies in Children Admitted into the Hospital
… Chest radiographs, steroids, and certain bronchodilators are considered ineffective treatments. This study identified the amount of ineffective procedures being used in infants admitted into the pediatric emergency room, and the effect it had on the patient’s average hospital stay. Past …
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Assessment of airflow obstruction from tidal breathing expiratory flow recordings in patients with chronic obstructive pulmonary disease
… does not detect all the physiological effects of bronchodilators. Iftidal breathing is measured, a number of the disadvantages of FEVi are overcome. It is effort-independent, requires no learning of special breathing manoeuvres on the patient's part and so can be performed even in acutely …
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Influence of Obstructive Sleep Apnea (OSA) on Rostral Fluid Shift, and the Pathophysiology on Asthma
… we investigated whether asthma treatment with bronchodilators can prevent the airway narrowing that is attributable to rostral fluid shift. It was found that small airway narrowing would increase after application of LBPP, both with and without bronchodilator (Chapter 5). Finally, we developed …
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Immunopathological and Structural Alterations in Difficult to Control Asthma
… Most patients with asthma can be controlled with bronchodilators and low to moderate dose inhaled corticosteroids. However, an estimated 5-10% of the population presents a more troublesome disease, often referred to as severe asthma. The aim of present thesis was to study the relationship between …
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The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical Ingredients; Bespoke Analytical Method Development Leading to Novel Formulation Approaches for Product Development.
… (ICS), β2-adrenoagonists and antimuscarinic bronchodilators, and have highlighted solubility variations between the classes of compounds with lipophilic ICSs showing the highest, and hydrophilic β2- agonist / antimuscarinics showing the lowest solubilities from the compounds under study. To …
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Ergogenic Effects of Intake of Salbutamol, Caffeine and Theobromine on Non-Asthmatic Subjects
… caffeine and theobromine have been regarded as bronchodilators and whilst the potential ergogenic effects of caffeine have led to its WADA monitored status no such information exists for theobromine. Study 1 investigated the ergogenic effect of 800 µg and 1600 µg of salbutamol in a randomised, …
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Best-Practice Evidence Based Medicine for the Effective Management of Chronic Obstructive Pulmonary Disease (COPD)
… reduced mortality. Routine use of short acting bronchodilators in the hospital setting to treat AECOPD should be initiated at a low dose (2.5mg) of salbutamol delivered via metered-dose inhaler to avoid increased risk of adverse events. Smoking cessation is essential to COPD management and …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
… Formoterol, are effective long-acting inhaled bronchodilators. These drugs stimulate increases in cAMP which activates protein kinase A (PKA) dependent signaling pathways in airway smooth muscle, leading to relaxation and a decrease in airway resistance. The therapeutic benefit of ICS treatment …
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Learning and model-based approaches to improved patient monitoring, assessment and treatment in capnography and procedural sedation
… classified as normal when treated with bronchodilators after the challenge. Procedural sedation refers to the use of medications to alleviate patient pain and anxiety during medical procedures performed outside the operating room. We demonstrate that online clustering of features …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… Patient treatment options are limited including bronchodilators and inhaled corticosteroids that are poorly effective. Linked with a significant history of cigarette smoking, pathology is characterised by recruitment of inflammatory cells to the lung (alveolar macrophages, neutrophils and …