Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"bronchoalveolar lavage (BAL)"”.
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Pharmacokinetics and pulmonary distribution of Draxxin® (tulathromycin) in healthy adult horses
… were used. Drug concentrations in blood and bronchoalveolar lavage (BAL) samples were determined by ultra-performance liquid chromatography tandem mass spectrometry and pharmacokinetic parameters calculated using noncompartmental analysis. Following SC and IM administration, all horses …
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… asthma. MATERIALS AND METHODS: Sensitized BALB/c mice were intragastrically treated withP113(30mg/kg) 30 minutes before OVA challenge. Airway responsiveness (AHR), cell composition and cytokine levels in bronchoalveolar lavage (BAL) fluid were evaluated.Human eosinophil EOL-1 cells were …
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Myeloid-Specific ARNT Signaling Drives Sex-Based Differences in Acrolein-Induced Pulmonary Toxicity
… 24-hour timepoint, single-cell RNA sequencing, bronchoalveolar lavage (BAL) cytokine profiling, and immune cell phenotyping revealed that female Arnt-a transgenic mice exhibited attenuated neutrophilic inflammation, reduced proinflammatory cytokine expression, and accumulation of FOXP3+ …
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The Comparison of Airway Responses of Normal Horses Fed Round Bale versus Square Bale Hay
Background – Feeding horses round bale hay (RBH) has been associated with airway inflammation. The purpose of this study was to determine if horses fed RBH for a 6-week period demonstrated more evidence of airway inflammation than horses fed square bale hay (SBH) of comparable quality. Hypothesis - …
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Adaptation of Three Different Apoptotic Methods in Equine Bronchoalveolar Cells and Comparison of Bronchoalveolar Lavage Cell Apoptosis in Normal and COPD Affected Horses Before and After Dexamethasone Administration
… linear relationship was found for equine bronchoalveolar lavage (BAL) lymphocytes stained with 7-AAD and Annexin/PI . No relationship was identified with cells stained with PI/Triton-X and Annexin/PI, and 7-AAD and PI/Triton-X indicating that methods which preserve cell membrane …
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Mechanisms of HIV-Nef Induced Endothelial Cell Stress: Implications of HIV-Nef Protein Persistence in Aviremic HIV Patients
… (i) extracellular vesicles (EV) of plasma and bronchoalveolar lavage (BAL) fluid and (ii) PBMC and BAL derived cells. Here I demonstrate that the presence of HIV-Nef protein in cells and EV is capable of stressing endothelial cells by inducing ROS production leading to endothelial cell …
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Response of Peripheral Blood Lymphocytes from RAO-affected Horses to b2-Agonist Stimulation
… through the β2-AR. Preliminary investigation of bronchoalveolar lavage (BAL) lymphocytes from RAO horses demonstrated that they also responded to β2-agonist binding, while cells from non-affected horses did not. These findings represent a novel tool for further investigation of the role of …
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Amiodarone-induced pulmonary toxicity in F344 rats
… fibrosis on day 28 in the AD-treated animals. Bronchoalveolar lavage (BAL) resulted in the increased recovery of alveolar macrophages, neutrophils, and eosinophils from i.t. AD-treated rats. The BAL cells recovered from AD-treated rats at day 3 produced more integrated phorbol-myristate-acetate …
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Transport and utilization of arginine and arginine-containing peptides by rat alveolar macrophages
… measurement of Arg and ACPs in rat plasma and bronchoalveolar lavage (BAL) fluid. The uptake of small peptides by rat AM was evaluated using fluorescein isothiocynate (FITC)-labeled (*) peptides (Arg-Lys*, beta-Ala-Lys*, and Gly-Sar-Lys*), HPLC analysis of potential peptide degradation, and …
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Ambient particulate matter as a trigger for acute exacerbations of asthma
… by which this occurs. Methods and Results: BALB/c mice were sensitised to ovalbumin and repeatedly challenged with a low mass concentration (~3 mg/m3) of aerosolised ovalbumin for 4 weeks. Animals received a single dose of ambient particulate matter, collected in the geographical centre of …
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NK cell determinants of immunity to mycobacterium tuberculosis in humans
… from peripheral blood, lung, hilar lymph nodes, bronchoalveolar lavage (BAL), and spleen, NK cell phenotypes and cytotoxic potential were characterized by mass cytometry. Results showed that NK cells in the peripheral blood of TB patients displayed predominantly mature, activated phenotypes, …
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Protein Kinase C - delta (PKC-δ): a critical hub for immunomodulatory functions in macrophages during Mycobacterium tuberculosis infection
… as the second deadliest infectious disease globally after CoVID-19. By evolving the ability to evade host defense via intrinsic mechanisms, Mycobacterium tuberculosis (Mtb), the etiological agent of TB has been deleterious to human health and has necessitated novel therapeutic interventions, …
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Pulmonary disposition and pharmacokinetics of minocycline in the adult horse
… the pulmonary epithelial lining fluid (PELF) and bronchoalveolar lavage (BAL) cells at concentrations exceeding those in plasma within 3 hours of IV or IG administration and achievable trough concentrations in the PELF and BAL cells after administration of IG minocycline would exceed a target …
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Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
… and inflammatory cytokines TNFα and IL-6 in the BALF. Disease severity in HP is associated with granuloma formation and a Th17 response. After 3 weeks exposure to SR, our results demonstrate a decrease in IL-17 and IL-22 mRNA expression and a corresponding decrease in the percentage of Th17 cells …
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How does pulmonary exposure to particulate matter predispose the heart to increased injury after myocardial infarction?
… autonomic reflexes in the lung. Examination of bronchoalveolar lavage (BAL) fluid revealed pulmonary inflammation 6 h after exposure to DEP, characterised by neutrophil infiltration, raised levels of the inflammatory mediator interleukin-6 (IL-6) and an increase in alveolar permeability …
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Purification and quantitative description of Rhodococcus equi IgG designed for aerosol nebulization to foals
… pulmonary delivery and safety of administration. Bronchoalveolar fluid was retrieved endoscopically using a low volume technique prior to aerosolization (time 0) and at 0.5, 4 and 24 hours post aerosolization. The BAL fluid IgG concentration was determined and cytologic analysis was performed. The …
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Cellular innate immune responses to lung resection via video- assisted thoracoscopic surgery (VATS) and thoracotomy : predictors of post-operative pneumonia
… criteria were used to diagnose pneumonia. Bronchoalveolar lavage (BAL) was conducted in the contra-lateral lung pre- and postoperatively to measure cellular composition and cytokines. Blood was sampled preoperatively and 6-, 24- and 48-hours post-operatively primarily to assess neutrophil …