Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"bronchiectasis"”.
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Characterisation of exacerbations in non-CF Bronchiectasis to establish endpoints in measuring treatment efficacy
Bronchiectasis is characterised by chronic cough productive of mucopurulent sputum and frequent exacerbations. We have aimed to validate clinical, biochemical and microbiological endpoints to aid planning of future interventional studies. We recruited fifty-eight subjects with bronchiectasis at the …
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Bronchektazės. Literatūros apžvalga ir klinikinis atvejis /
Bronchiectasis is a chronic respiratory disease characterised by radiologically observed irreversible abnormal dilatation of the bronchial lumen, and clinically manifested episodes of persistent cough, sputum production and recurrent respiratory tract infections. In recent decades, the incidence …
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Bronchiectasis in African children: disease burden, aetiology and clinical spectrum at a paediatric tertiary hospital in Cape Town, South Africa
Childhood bronchiectasis is a common cause of chronic lung disease globally, particularly in lower-middle-income countries (LMIC). Data from LMIC is lacking. We aimed to describe the disease burden, aetiology, and clinical spectrum of bronchiectasis in children attending a tertiary hospital in Cape …
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The experience of palliative care service provision for people with non-malignant respiratory disease: an all-Ireland qualitative study
… care for people with interstitial lung disease, bronchiectasis and COPD. This study aimed to explore the experience of palliative care provision for people with non-malignant respiratory disease and their bereaved carers. <br/>Methods: Qualitative study involving a convenience sample of 17 …
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Novel methods within a randomised controlled trial in respiratory disease
… number of studies were embedded within the CLEAR bronchiectasis trial. Studies investigated remote data collection in lung function using patient-led technology, the use of remote patient reported outcomes within the new standardised EMBARC framework for exacerbations and novel Studies Within A …
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Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease
… includes: airway narrowing (from bronchiolitis, bronchiectasis or persistent low-grade inflammation associated with healed PTB); and reduced lung elastic recoil from coexistent emphysema. The present study investigated the structure and function of the lung in subjects with …
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The role of genetic and environmental variation in the respiratory phenotype of alpha 1 antitrypsin deficiency
… TGFB with small airways disease and GC with bronchiectasis, consistent with the role of protein products in pathogenesis. Of four MMPs studied, association with gas transfer occurred in two. HLA-DQA1*0301 and HLA-DRB1*04 contributed significantly to gas transfer in regression models, and anti …
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Building capacity for diagnosis of Primary Ciliary Dyskinesia in South Africa: a descriptive study
… (91%, n=30), chronic wet cough (73%, n=24), bronchiectasis (36%, n=12), neonatal respiratory distress (48%, n= 16), and situs inversus (36%, n=12); 7/17 (41%) participants recorded nNO <77nl/. Ciliary beat pattern and TEM were abnormal in 55% (n=18) and 6.1% (n=2) of the participants …
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Development of an inhaled liposomal-loaded azithromycin formulation for the treatment of chronic respiratory infection
… lung conditions such as cystic fibrosis and bronchiectasis are characterised by cycles of inflammation and infection. Long term antibiotics are commonly prescribed in these conditions to decrease exacerbation frequency and improve quality of life. Azithromycin is often given orally for this …
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The use of computer aided lung sound analysis to characterise adventitious lung sounds: a potential outcome measure for respiratory therapy
… productive lung disorders (cystic fibrosis and bronchiectasis) were recruited from out-patient clinics. Demographic, anthropometric, lung function, oxygen saturation, breathlessness and lung sound data were collected at baseline and after a single intervention (selfintervention in the first …
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The Clinical Spectrum, Aetiology and Disease Progression of Children with Post-infectious Bronchiolitis Obliterans at Tertiary Paediatric Pulmonology Service in Cape Town, South Africa
… most common current chest radiographic findings; bronchiectasis in 45% of patients. Spirometry showed mixed (41.4%) or obstructive (27%) patterns, mean (SD) FEV1 z-score - 3.3(±1.4), FVC z-scores -2.4(±1.6) and FEV1/FVC z-score -3.1(±2.4). Corticosteroids were used during initial presentation in …
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Tomosynthesis in pulmonary cystic fibrosis
… designed and validated, and proved to be robust. Bronchiectasis and mucus plugging are the most specific pulmonary changes of cystic fibrosis, and were in a review of commonly used radiological scoring systems generally considered the most important scoring components. For chest tomosynthesis in …
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MUTATION OF REGNASE-1 CAUSES PRIMARY IMMUNODEFICIENCY ASSOCIATED WITH AUTO-INFLAMMATORY DISEASE
… recurrent respiratory infections leading to bronchiectasis and had several episodes of severe varicella zoster virus (VZV) infections, including pneumonia and meningitis. Immunologically, the patient had increased IgM and IgG levels, absent IgA, low specific antibodies and multiple …
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Monocyte adherence to fibronectin: role of CD11/CD18 integrins and relationship to other monocyte functions
… from patients with an inflammatory lung disease (bronchiectasis) and healthy subjects to a representative matrix component (fibronectin) were compared. Spontaneous adherence of monocytes from the control subjects was 20 to 25%, whereas that of the patients' cells was 2 to 3-fold higher and …
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Deciphering the mechanism of foxa2 inactivation by respiratory pathogens in chronically diseased lungs
… primary ciliary dyskinesis (PCD), bronchitis and bronchiectasis. Because accumulated mucus provides a niche environment of microbes to thrive, muco-obstructive lungs are especially vulnerable to infection by microbial pathogens. Pseudomonas aeruginosa is an important bacterial pathogen in …
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Allergic bronchopulmonary aspergillosis in cystic fibrosis: prevalence, clinical complications, diagnosis and influence on the outcome
… ABPA may lead to lung damage, including proximal bronchiectasis and segmental , lobar or whole lung collapse. This thesis describes a cross-sectional study on prevalence of ABPA, atopy as a risk factor in the development of ABPA and reveals a prevalence of 21% of ABPA in our cohort of adult …
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Protein-Protein Interactions in Cell Cycle Proteins: An <i>In silico</i> Investigation of Two Important Players
… NEK10’s participation in various disorders, such bronchiectasis syndrome, breast cancer, and lung cancer. However, NEK10 is largely understudied. To address the lack of structural information for NEK10 we modeled and characterized the full-length NEK10 protein as well as for its homolog in<em> …
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A retrospective review of lung disease in adolescents living with human immunodeficiency syndrome
… evidence of bilateral lung disease with bronchiectasis and cavitation was ubiquitous. Haemophilus influenzae was isolated in 12/17 (70.6%) patients and Methicillin-resistant staphylococcus aureus (MRSA) in 2/17 (11.7%) patients). The median FVC as a percentage of predicted values was …
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Investigation of the host-mediated proteolytic response to pulmonary Mycobacterium Avium Complex infection
… develop cavitating lung disease or nodular bronchiectasis. Prolonged treatment is required, frequently not tolerated, and often associated with progressive lung destruction. A large body of evidence suggests the tissue damage that occurs during tuberculous lung disease is driven by …
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