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Showing 1 to 5 of 5 for “"brominated furanones"”.
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Controlling Bacterial Persister Cells and Biofilms by Synthetic Brominated Furanones
… study, we characterized the effects of synthetic brominated furanones, a group of QS inhibitors, on the persistence of P. aeruginosa and Escherichia coli. Our results revealed that (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8) can reduce persister formation in P. aeruginosa PAO1 and …
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Discovering the Biological Activities of Maltose Derivatives for Controlling Bacterial Multicellular Behaviors
… nonmicrobicidal agents, maltose derivatives and brominated furanones, as modulators of different bacterial multicellular behaviors has been demonstrated. Rhamnolipids secreted by Pseudomonas aeruginosa are biosurfactants that are known to be essential for at least three multicellular behaviors of …
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I. Stereochemical Control of Chiral Assembly and Liquid Crystal Phase Formation of Nonamphiphilic Molecules in Water II. Control Bacterial Quorum Sensing and Quorum Sensing-mediated Activities Using Small Unnatural Molecules
… and biological studies of a class of bicyclic brominated furanones. These molecules interacted with quorum sensing in an opportunistic pathogen P. aeruginosa. Some representative compounds in this class inhibited quorum sensing-controlled activities such as biofilm formation and virulence …
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Controlling Biofouling by Surface Engineering and Molecular Inhibition
… of derivatives of a class of molecules called brominated furanones, which are known to inhibit biofilm formation in E. coli. Chapter 7 reports the synthesis of novel squarate based molecules named squarylated homoserine lactones (SHLs), which are structural mimics of the bacterial autoinducer …
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Novel small molecules for modulation of bacterial signaling pathways
… heterocyclic systems derived from halogenated furanones (Fimbrolides). Indole and glucosamine-based amides and oxo-amides were synthesized as non-native AHL mimics by applying EDC, DCC or EDC/HOBt mediated amide coupling methods. On docking study, the indole-based AHL mimics showed strong …