Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"broadly neutralizing antibody"”.
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HIV prophylaxis: an essential role for T cells and adjuvants in recombinant mucosal Lactobacillus acidophilus vaccines
… (MPER), a portion of HIV envelope that contains broadly neutralizing antibody binding sites. We evaluated MPER-only expressing strains along with strains expressing adjuvants (interleukin-1β or flagellin) to improve immunogenicity against the HIV MPER. We compared the adjuvant strains to the …
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Development and Characteristics of the Earliest Cross-Neutralizing Antibody Response to HIV-1
A neutralizing antibody response of sufficient potency, magnitude and duration is considered an important part of a successful HIV vaccine. A better understanding of the factors associated with the development of broadly neutralizing antibody responses (effective against a wide range of clinical …
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HIV-1 strain-specific neutralizing antibody responses and the dynamics of viral evolution
… sterilizing immunity, it would need to elicit broadly neutralizing antibodies (bnAbs). However, factors underlying the development of these antibodies are not clear. There is evidence to suggest that in some individuals who develop bnAbs, the development of breadth is influenced by the …
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HIV Specific B Cell Response in Patients With Broadly Neutralizing Serum Activity
… HIV infected individuals develop high titers of broadly neutralizing IgG antibodies in their serum, but until recently very little was known about the specificity and activity of these antibodies. To characterize the broadly neutralizing memory antibody responses to HIV we cloned 1078 antibodies …
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Enhancement of HIV vaccine efficacy via lipid nanoparticle-based adjuvants
… strong anti-gp120 titers which competed with the broadly-neutralizing antibody VRC01. The second HIV antigen used was a peptide derived from the membrane proximal external region (MPER) of the gp41 protein. High-titer IgG responses to MPER required the presentation of MPER on liposomes and the …
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Targeting the CD4 Binding Site of HIV
<p>The immunologic obstacles to develop a broadly neutralizing antibody (bNAb) against HIV by vaccine mandate for methodical testing in order to understand and direct the immune response. A mouse model with the predicted human heavy chain variable domain of a bNAb precursor or mature version …
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Conformational engineering of human chemokine receptors and HIV-1 Env using deep mutational scanning
… BaL and DU422 isolates interacting with CD4, or antibody PG16 that preferentially recognizes closed trimers. Notably, the Env apical domain and trimerization interface are under selective pressure for PG16 binding. Based on this observation, mutations were found that increase presentation of …
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The Ontogeny of Vaccine-Induced HIV-1 Glycan-Reactive Antibodies
… on the virion surface is the target for both non-neutralizing and neutralizing antibodies (nAbs). In both infection and vaccination, the dominant neutralizing antibody responses are strain-specific, however, during chronic infection, antibodies that can potently neutralize genetically diverse …