Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"broad-spectrum antimicrobial activity"”.
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NGC-HLB, a novel antimicrobial peptide from the skin secretion of Hylarana latouchii
Antimicrobial peptides from amphibian skin secretions are considered to play a significant role in the host defence mechanisms against bacterial infection. In this study, the identification and antimicrobial activity of a novel peptide named NGC-HLB (GLLSGILGAGKKIVCGLSGLC), is described. The …
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Identification, characterisation and design of bioactive peptides from Chinese frogs
Antimicrobial peptides from amphibian skin secretions have become candidates as replacements for conventional antibiotic therapies. Temporin is an AMP type found in skin secretions of frogs from the family Ranidae, In Chapter 3, a novel temporin family peptide, QUB1434, was identified from …
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Protective and Anti-inflammatory Effects of Protegrin-1 on Citrobacter rodentium Intestinal Infection in Mice
… millions of humans and food-animals world-wide. Antimicrobial peptides (AMPs) and their broad-spectrum antimicrobial activity represent a valuable potential therapeutic solution. Specifically, the potent pig-originated protegrin-1 (PG-1) has previously been shown to reduce the pathological …
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A bioactive peptide QUB3009 from the defensive skin secretion of the frog, Phyllomedusa tomopterna
… amines, alkaloids, peptides and proteins. Antimicrobial peptides from frog skin secretions display vital broad-spectrum antimicrobial activity and have been promoted for the research of novel chemical drugs.<br/><br/>In this thesis, an antimicrobial peptide from the defensive skin secretion …
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The characterization of two novel class II lanthipeptides from Thalassomonas viridans by heterologous expression in Escherichia coli
… 4.95 million people died from illnesses where antimicrobial resistance played a role, of which 1.27 million people died as a direct result of antimicrobial resistance. With the rising emergence of antibiotic-resistant microorganisms, there is an urgent need for the discovery and development of …
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The characterization of two novel class II lanthipeptides from thalassomonas viridans by heterologous expression in escherichia coli
… 4.95 million people died from illnesses where antimicrobial resistance played a role, of which 1.27 million people died as a direct result of antimicrobial resistance. With the rising emergence of antibiotic-resistant microorganisms, there is an urgent need for the discovery and development of …
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Pathogen Membrane Interactions
… and hydrophobic interactions. Natural antimicrobial peptides and their synthetic derivatives are amphipathic molecules with broad-spectrum antimicrobial activity, but the underlying mechanism needs clarification. We systematically investigated interactions between model bacterial …
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QUB-2577: A Bioactive Peptide from Pickerel Frog (Rana palustris) Skin Secretion
… secretion of frogs contains a large number of antimicrobial peptides (AMPs) and they are considered as a promising source of antibiotic alternatives.<br/>In this thesis, the peptide QUB-2577 was identified by "shotgun" cloning of precursor-encoding cDNA derived from the skin secretion of Rana …
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Evaluation of bioactivity of QUB1977 from the skin secretion of the frog, Phyllomedusa camba
… It is proven that many of these peptides exhibit antimicrobial, anticancer, antiviral and trypsin inhibitory activities and therefore their potential promising therapeutic value has drawn great attention from numerous researchers<br/>In this study, a novel antimicrobial peptide was isolated and …
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Discovery and bioactivity assessment of a peptide QUB-1331 from the skin secretion of the Senegal running frog (Kassina senegalensis)
Since more and more antimicrobial peptides exhibited enormous potency in inhibiting the growth of microorganisms, especially bacteria and fungi, they have been regarded as alternative therapeutic reagents for various treatments in clinic. <br/><br/>In this research, a novel peptide QUB-1331 …
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Host-defence peptides from frog skin secretions: identification and bioactivity evaluation and optimisation
… of antibiotic resistance, new types of antimicrobial drugs are urgently needed. A novel AMP, Brevinin-1H, was isolated from skin secretion of Amolops hainanensis (A. hainanensis) with broad spectrum antimicrobial activity, anti-proliferative activity, and strong haemolytic activity. Two …
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Specificity of Interaction of Antimicrobial Peptide with Cell Membrane
<p>Antimicrobial resistance (AMR) is an increasing global health threat due to its rising incidence worldwide. Resistant microbial infections have become difficult to treat and pose serious risks to patients. In 2019, AMR was responsible for approximately 1.27 million deaths globally, with numbers …
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Discovery, structural characterisation and targeted engineering of bioactive peptides from amphibian skin secretion
… of novel bioactive peptides. Among these, the antimicrobial peptides (AMPs) have demonstrated an outstanding efficacy in killing microorganisms via a general membranolytic mechanism, which may offer a prospect of solving specific target driven antibiotic-resistance. Here, the discovery of three …
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QUB-1985: a bioactive peptide from the frog skin secretion of Odorrana livida
… agents to replace conventional antibiotics. Antimicrobial peptides (AMPs), possessing broad-spectrum antimicrobial activity, have raised great interests among medical field for its potential bioactivity against bacteria, fungi, viruses and cancer cells and its multi-target mechanisms. …
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Assessing bioactivity of a peptide from the skin secretion of the central American red-eyed leaf Frog, Agalychnis callidryas
… range of bioactive functions, especially the antimicrobial peptides with positive charge, α-helical structure and strong amphiphilicity. In this study, QUB-2428, a peptide related to the plasticins from the dermaseptin superfamily, was isolated from the skin secretion of the Central American …
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A bioactive peptide, QUB-2048, from the defensive skin secretion of Phyllomedusa tomopterna
… deemed as a reservoir of bioactive compounds and antimicrobial peptides (AMPs) are among the most attractive of these. Due to antibiotic resistance and the eager need of developing new types of anti-infective drugs, such peptides are considered as an alternative therapeutic option due to their …
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Efeitos cronotropico e inotropico negativos induzidos pelo timol em ratos espontaneamente hipertensos
… oils of many plants and is well known for its broad spectrum antimicrobial activity and is also reported in the literature their activities on the cardiovascular system . Therefore , this study aimed to evaluate the chronotropic and inotropic effects induced by thymol in the SHR rats , an …
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Identification and functional study of a novel antimicrobial peptide, QUB-2014, from the skin secretion of the frog, Phyllomedusa tomopterna
… various bioactive compounds. Among these, antimicrobial peptides (AMPs) are vitally important as they protect amphibians from the attack of microorganisms. Some studies showed that AMPs are considered the new potential antibiotic candidates for humans and these molecules are also beneficial …
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ANTIMICROBIAL ACTIVITIES OF HISTIDINE-RICH GLYCOPROTEIN AND CATIONIC PEPTIDES
… organisms to mount a fast and effective defence. Antimicrobial peptides are ancient and integral effector molecules of the innate immune system. They are found in all kinds of species from bacteria to plants and animals, indicating their importance during evolution. They possess a broad-spectrum …
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Revisão sistemática do óleo essencial da espécie Plectranthus amboinicus (Lour.) Spreng.
… as GRAS (Generally Re cognized as Safe) having broad spectrum antimicrobial activity and showing efficacy in controlling of pathogenic and spoilage micro - organisms of importance in vegetables. However, area of the authors have acknowledged that investigations so far are insuf ficient, making …
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