Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"broad-spectrum antimicrobial"”.
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NGC-HLB, a novel antimicrobial peptide from the skin secretion of Hylarana latouchii
Antimicrobial peptides from amphibian skin secretions are considered to play a significant role in the host defence mechanisms against bacterial infection. In this study, the identification and antimicrobial activity of a novel peptide named NGC-HLB (GLLSGILGAGKKIVCGLSGLC), is described. The …
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Identification, characterisation and design of bioactive peptides from Chinese frogs
Antimicrobial peptides from amphibian skin secretions have become candidates as replacements for conventional antibiotic therapies. Temporin is an AMP type found in skin secretions of frogs from the family Ranidae, In Chapter 3, a novel temporin family peptide, QUB1434, was identified from …
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A bioactive peptide QUB3009 from the defensive skin secretion of the frog, Phyllomedusa tomopterna
… amines, alkaloids, peptides and proteins. Antimicrobial peptides from frog skin secretions display vital broad-spectrum antimicrobial activity and have been promoted for the research of novel chemical drugs.<br/><br/>In this thesis, an antimicrobial peptide from the defensive skin secretion …
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Carbapenem and piperacillin-tazobactam prescribing in a hospital setting in Kingdom of Saudi Arabia : a mixed methodology study
Background: Antimicrobial resistance (AMR) is spreading rapidly and is considered tobe one of the greatest public threats worldwide. The inappropriate use of broadspectrum antimicrobials has contributed to the emergence of AMR. The WHO hasdeveloped Access, Watch, Reserve (AWaRe) classification to …
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The characterization of two novel class II lanthipeptides from Thalassomonas viridans by heterologous expression in Escherichia coli
… 4.95 million people died from illnesses where antimicrobial resistance played a role, of which 1.27 million people died as a direct result of antimicrobial resistance. With the rising emergence of antibiotic-resistant microorganisms, there is an urgent need for the discovery and development of …
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The characterization of two novel class II lanthipeptides from thalassomonas viridans by heterologous expression in escherichia coli
… 4.95 million people died from illnesses where antimicrobial resistance played a role, of which 1.27 million people died as a direct result of antimicrobial resistance. With the rising emergence of antibiotic-resistant microorganisms, there is an urgent need for the discovery and development of …
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Pathogen Membrane Interactions
… and hydrophobic interactions. Natural antimicrobial peptides and their synthetic derivatives are amphipathic molecules with broad-spectrum antimicrobial activity, but the underlying mechanism needs clarification. We systematically investigated interactions between model bacterial …
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Discovery and bioactivity assessment of a peptide QUB-1331 from the skin secretion of the Senegal running frog (Kassina senegalensis)
Since more and more antimicrobial peptides exhibited enormous potency in inhibiting the growth of microorganisms, especially bacteria and fungi, they have been regarded as alternative therapeutic reagents for various treatments in clinic. <br/><br/>In this research, a novel peptide QUB-1331 …
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QUB-2577: A Bioactive Peptide from Pickerel Frog (Rana palustris) Skin Secretion
… secretion of frogs contains a large number of antimicrobial peptides (AMPs) and they are considered as a promising source of antibiotic alternatives.<br/>In this thesis, the peptide QUB-2577 was identified by "shotgun" cloning of precursor-encoding cDNA derived from the skin secretion of Rana …
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Evaluation of bioactivity of QUB1977 from the skin secretion of the frog, Phyllomedusa camba
… It is proven that many of these peptides exhibit antimicrobial, anticancer, antiviral and trypsin inhibitory activities and therefore their potential promising therapeutic value has drawn great attention from numerous researchers<br/>In this study, a novel antimicrobial peptide was isolated and …
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Host-defence peptides from frog skin secretions: identification and bioactivity evaluation and optimisation
… of antibiotic resistance, new types of antimicrobial drugs are urgently needed. A novel AMP, Brevinin-1H, was isolated from skin secretion of Amolops hainanensis (A. hainanensis) with broad spectrum antimicrobial activity, anti-proliferative activity, and strong haemolytic activity. Two …
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Identification and functional study of a bioactive peptide QUB-1962 from the skin secretion of the yellow-bellied toad (Bombina variegata)
… more antibiotics have lost their due role. The antimicrobial peptide has become the most promising substance in the next class of antimicrobial agents. QUB-1962 is a cationic antimicrobial peptide isolated from the skin secretions of Bombina variegata. Using the "shotgun" cloning technique, a …
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The discovery and bioactivity evaluation of a novel peptide, QUB-2652, from the skin secretion of the South American frog, Phyllomedusa palliata
… stimulated the development of new antibiotics. Antimicrobial peptides (AMPs) from amphibian skin secretions possess broad-spectrum antimicrobial activities through the mechanism that is unlikely to induce antibiotic resistance. Thus, AMPs are great candidates for new antibiotics. <br/>In this …
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Specificity of Interaction of Antimicrobial Peptide with Cell Membrane
<p>Antimicrobial resistance (AMR) is an increasing global health threat due to its rising incidence worldwide. Resistant microbial infections have become difficult to treat and pose serious risks to patients. In 2019, AMR was responsible for approximately 1.27 million deaths globally, with numbers …
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The Design of Antimicrobial Detachable Thin Films for the Study of Hepatic Infections
… more common. It is imperative to explore broad spectrum antimicrobial approaches. In this work, we modified collagen/hyaluronic acid polyelectrolyte multilayers (PEMs) with the natural antimicrobial peptide, LL-37 to study hepatic infections. LL-37 was physisorbed and covalently linked to …
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Liposome-loaded biosynthetic bacterial cellulose hydrogels for wound management applications
… xylinus (ATCC 23770) and loaded with antimicrobial agents. Characterisation studies were carried out on these biosynthetic hydrogels for their wound healing properties. Due to the rise of antibiotic resistant bacterial strains, scientists are seeking other bioactive materials with …
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Discovery, structural characterisation and targeted engineering of bioactive peptides from amphibian skin secretion
… of novel bioactive peptides. Among these, the antimicrobial peptides (AMPs) have demonstrated an outstanding efficacy in killing microorganisms via a general membranolytic mechanism, which may offer a prospect of solving specific target driven antibiotic-resistance. Here, the discovery of three …
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Silver Nanoparticles and the Plant-Associating Abilities of Rhizobiaceae Bacteria
… products has been increasing due to their broad-spectrum antimicrobial properties. Specifically, silver nanoparticles (AgNPs) can demonstrate distinct physiochemical properties compared to bulk silver, including a large surface area to volume ratio that allows for higher reactivity with …
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Discovery and bioactivity assessment of a novel peptide from the skin secretion of the Senegal running frog Kassina senegalens
… with an abundance of biologically active antimicrobial peptides (AMPs) with a broad-spectrum effect against a variety of microorganisms. The contribution of their complex and diverse structures, physicochemical properties and mechanisms of biological activity, have been discovered and …
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Assessing bioactivity of a peptide from the skin secretion of the central American red-eyed leaf Frog, Agalychnis callidryas
… range of bioactive functions, especially the antimicrobial peptides with positive charge, α-helical structure and strong amphiphilicity. In this study, QUB-2428, a peptide related to the plasticins from the dermaseptin superfamily, was isolated from the skin secretion of the Central American …
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