Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"broad-spectrum antibiotic"”.
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Synthesis of an isotopically labelled analog of the antimicrobial peptide ll-37
<p>LL-37 is a cationic cathelin-associated broad spectrum antibiotic peptide of human neutrophils. Its mechanism of action is by disruption of the bacterial cell membrane structure. LL-21 is a simplified form of the peptide that contains only the core portion of LL-37, which retains antimicrobial …
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Investigations into the biosynthesis and mode of action of the phosphonate antibiotic dehydrophos
… by Streptomyces luridus with demonstrated broad spectrum antibiotic activity. Dehydrophos antibiotic activity was determined to be dependent on uptake into the cell via non-specific oligopeptide permeases, followed by aminopeptidase catalyzed digestion. Bioactivity was abolished in …
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A tissue-engineered approach to hernia repair
… antibacterial agent) or levofloxacin (LEVO) (a broad-spectrum antibiotic). Type I collagen was later included into the polymer-drug solutions in order to increase the biocompatibility of the samples. Electrospun samples were subsequently analysed for mechanical, physicochemical, drug release and …
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An antimicrobial peptide QUB-1925 from scorpion venom of Androctonus bicolor: molecular cloning of biosynthetic precursor-encoding cDNA and bioactivity study
… suggests that QUB-1925 has the potential to be a broad-spectrum antibiotic with low level of haemolytic activity. However, this cytotoxicity can not be ignorable. Future studies on the modification of AMP discovered from scorpion venom are therefore recommended.<br/><br/><i>Thesis embargoed until …
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Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications
… The ues of nanoparticles encapsulated with antibiotics to deliver drugs has been shown to be a potentially effective approach to control bacterial infections at a wound position. Recently, biodegradable and biocompatible polymers have drawn lots of attention for the manufacture of …
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Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia
… appropriately, leading to widespread empirical broad-spectrum antibiotic use, which contributes to development of antimicrobial resistance in hospitals. We hypothesise that greater understanding of host-microbe interactions (HMI) in the pathogenesis of VAP should dictate appropriate treatment. …
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Learning treatment policies for empiric antibiotic prescription
Rising antibiotic resistance rates pose a serious public health threat and are largely driven by overuse and inappropriate use of antibiotics. Antibiotic stewardship efforts have been established around the world to improve prescription practices, but further optimization of antibiotic usage is …
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Effect of Drugs on Rabbit Retina
… and histochemical methods. Rifabutin is a broad spectrum antibiotic with known ocular adverse effects (corneal opacities, uveitis and vascular retinopathy) in the human eye. In the rabbit eye rifabutin causes lens discoloration and it significantly reduces both total rod-cone function and …
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Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase and Mechanism of Action for the Antibacterial Agent Moiramide B
An urgent demand for the development of new antibiotics has been created by the increase in clinical cases involving drug-resistant pathogenic bacteria. A novel target for antibacterial development is acetyl-CoA carboxylase, a multifunctional enzyme that catalyzes the first committed step in fatty …
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Developing a microfluidic-microwave platform for real-time, non-invasive and sensitive monitoring of pathogens and antibiotic susceptibility testing
… quality of service is infection diagnosis and antibiotic susceptibility testing. Due to issues with infection diagnosis and outdated antibiotic susceptibility testing (AST) methods, physicians are over-prescribing broad-spectrum antibiotics. This coupled with patients’ non-compliance in …
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Ring distortion of the alkaloid sinomenine and novel prodrug approaches to broad-spectrum antibiotics
… infections as no new class of Gram-negative antibiotics has been introduced in several decades. The problematic nature of this epidemic lies in the composition of the Gram-negative bacterial membrane, as it is impermeable to most organic small-molecules. The eNTRy rules, developed by the …
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Development Of Peptide Inhibitors Targeting Clostridium Difficile Toxins A/b And Characterizing The Regulatory Role Of A Putative Negative Regulator Tcdc In Clostridium Difficile Toxin Gene Expression
… <p>diseases often associated with broad-spectrum antibiotic usage. TcdA and TcdB</p> <p>are the key virulence factors involved in major patho-physiology. While standard</p> <p>antibiotics provide some respite, due to the high relapse rates and the emergence of more</p> <p>severe …
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Developing a single dressing containing both antifungal and antibacterial drugs for treating mixed infections in diabetic foot ulcers
… will deliver therapeutically relevant doses of broad-spectrum antibiotic and antifungal drugs to target mixed infections in DFUs. The therapeutic calcium alginate (CA) based dressings were prepared as films and wafers by solvent casting and freeze-drying technique respectively, with …
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Antimicrobial Activity of Human Leukocyte Defensin HNP-4 Against Gram-negative Bacteria
… (α)-defensins or HNP 1-4. The peptides have broad-spectrum antibiotic activity. HNP 1-3 are major neutrophil components. They differ by only one amino acid residue. HNP-4 is found in small amounts, and has a different sequence. HNP-4 purified from neutrophils was reported to be 100-times more …
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Activity of Epithelial Defensin HBD-3 Against a Periodontal Pathogen
… are cationic (positive-charged) peptides with broad-spectrum antibiotic activity. In humans, there are two types of defensins, alpha (α) and beta (β). Human neutrophils contain four α-defensins known as Human Neutrophil Peptide (HNP) 1-4. Epithelial cells produce four β-defensins known as Human …
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Ecological studies of Clostridioides difficile and COVID-19 infection with the application of space-time risk models
… as concerns have grown with emergent novel antibiotic-resistant infections. CDI has been shown to have a well-defined association with certain broad-spectrum antibiotic classes and other environmental factors, however, there is a gap in the literature aiming to understand these relationships …