Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"brevetoxin"”.
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In Vitro Metabolism Study of Brevetoxins by LC-ESI-MS
<p>Brevetoxins are natural neurotoxins that are produced by "red tide" algae. In this study, brevetoxin-1 and brevetoxin-2 were incubated with rat liver hepatocytes and rat liver microsomes, respectively. After clean-up steps, samples were analyzed by liquid chromatography (LC) coupled with …
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Development of Novel Liquid Chromatography-Electrospray Tandem Mass Spectrometry Approaches for the Structural Characterization of Brevetoxins Including in vitro Metabolites
Brevetoxins are natural neurotoxins that are produced by “red tide†algae. In this study, brevetoxin-1 and brevetoxin-2 were incubated with rat liver hepatocytes and rat liver microsomes, respectively. After clean-up steps, samples were analyzed by liquid chromatography-electrospray mass …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… this study, we used a sodium channel activator, brevetoxin-2 (PbTx-2) to mimic neuronal activity. Brevetoxins interact with binding site 5 on the α subunit of VGSCs. PbTx-2 was found to increase intracellular sodium concentration ([Na+]i) in immature cerebrocortical neurons above the critical …
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Synthetic diversity in C-H activation: development of selective and efficient C-H functionalization reactions
… of molecular giants such as amphotericin and brevetoxin A, it becomes increasingly apparent that the complexity of the target defines the time and resources needed, rather than the likelihood of success in reaching the target compound. This has, in part, nourished a general desire to develop …