Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"breast tumor"”.
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Telomerase Inhibition and Sensitization of Breast Tumor Cells
… chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer cells. Telomerase is an attractive anticancer therapeutic target because its activity is present in over 90% of human cancers, including more than 95% of breast carcinomas, …
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ROLE OF AUTOPHAGY IN RADIOSENSITIZATION OF BREAST TUMOR CELLS
In MCF-7 breast tumor cells, ionizing radiation promoted autophagy that was cytoprotective; pharmacological or genetic interference with autophagy induced by radiation resulted in growth suppression and/or cell killing (primarily by apoptosis). The hormonally active form of vitamin D, 1,25D3, also …
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Intra-operative Assessment of Breast Tumor Margins Using Diffuse Reflectance Spectroscopy
<p>Breast cancer is one of the leading causes of death every year in the United States for women. Breast conserving surgery (BCS) is one treatment option for these patients where achieving tumor-free surgical margins is desired to avoid local recurrence [1, 2]. Unfortunately, as many as 17.7-72% of …
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N-(3-Oxododecanoyl)-L-Homoserine Lactone in the Breast Tumor Microenvironment
The tumor microenvironment is a well-recognized contributor to cancer progression in solid tumors. Cancer cell interactions with abnormal extracellular matrix, tumor associated immune and stromal cells, and aberrant fluid flow all contribute to cancer progression. Breast tumors are often …
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Role of protein kinase C isoforms in human breast tumor cell survival
… to identify specific PKC isoforms that promote breast tumor cell survival following radiation treatment. This work demonstrated that depletion of PKC delta and PKC zeta isoforms from MCF-7 and MDA-MB-231 human breast tumor cells by antisense oligonucleotides significantly impaired survival …
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A Theoretical Model Of Breast Tumor Metastases In The Context Of Tumor Dormancy
Metastasis is responsible for most breast cancer deaths and currently considered as a late event in the primary tumor process. Recent evidence suggests that tumor cells dissemination may occur when the tumor is at a size that does not normally warrant a systemic treatment. Current breast cancer …
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Design, Synthesis and Biological Properties of Estrogen Receptor Binding Breast Tumor Localizing Agents
… with the potential to act as breast tumor localizing agents. A mild, regioselective method for high yield radiobromination of enol acetate derivatives of D-ring steroidal ketones involving in situ oxidation of no-carrier-added radiobromide was developed for the synthesis of …
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Role of mural Cx43 in vascular interactions and its regulation by breast tumor cells
… the vessel and render the endothelium quiescent. Tumor vessels, in contrast, exhibit abnormal association between mural cells and endothelial cells which allows the endothelium to be angiogenic. The mechanism(s) by which tumors prevent mural-cell mediated vessel stabilization have not been well …
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Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
… the spheroid prior to lumen formation. In ductal breast carcinoma, a critical hallmark is the loss of normal polarized tissue architecture without the induction of an epithelial-to-mesenchymal transformation (EMT). Thus, misregulation of molecules that function as polarity determinants may …
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p,p' DDE Regulated Gene Expression and Possible Mechanisms of Action in Breast Tumor
… has been speculated to increase breast cancer risk due to its environmental persistence, levels of bioaccumulation in breast adipose tissue, and endocrine disrupting actions. Epidemiological studies have had inconsistent findings, however a study in MMTV-neu mice determined that …
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Nebulizer facilitated molding of freeform 3D printed sacrificial scaffolds for breast tumor microenvironment tissue engineering
… function in epithelial tissues including breast ducts, lungs, liver, and kidney. Cylindrical vessels are also necessary for expanding the size of model organs, delivering glucose and oxygen while removing CO2 and other waste products. Current methods for modeling organs, however, cannot …
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A Comparative Analysis of Classical Machine Learning Methods and Variational Quantum Methods for Breast Tumor Classification
Ο καρκίνος του μαστού αντιπροσωπεύει το 36% των γυναικείων ογκολογικών περιστατικών, καθιστώντας αναγκαία τη χρήση διαγνωστικών εργαλείων υψηλής ακρίβειας. Ενώ η παραδοσιακή μηχανική μάθηση αποτελεί το καθιερωμένο πρότυπο, η παρούσα μελέτη διερευνά την αποτελεσματικότητα των Μεταβλητών Κβαντικών …
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The Substituted Pyrrole JB-03-14 Induces Autophagic Cell Death and Growth Arrest in Breast Tumor Cells
… agents that are more potent at destroying tumor cell populations and more selective for the specific tumor versus normal host tissues. This project is directed at discovering new anti-tumor agents that are effective against breast cancer based on structures derived from marine organisms, …
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Development of Natural Cyclic Peptide Inhibitors of XRCC4/XLF Interaction for Radio-Sensitization of Breast Tumor Cells
Breast cancer is the second leading cause of cancer death in women according to the American Cancer Society. The standard treatment regimen for breast cancer involves ionizing radiation combined with surgery and chemotherapy. Ionizing radiation induces a complex signaling response in cells …
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Engineered microsystems and their application in the culture and characterization of three-dimensional (3D) breast tumor models
… have been utilized for engineering the tumor extracellular matrix, but very few studies have thoroughly characterized the phenotypic changes in their cell models, which is critical for translational applications of biomaterial systems. The overall objective of these studies is to …
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Improving Computation for Hierarchical Bayesian Spatial Gaussian Mixture Models with Application to the Analysis of THz image of Breast Tumor
… work that aims to improve the accuracy in breast cancer margin assessment using THz imaging technology. In particular, the Bayesian estimate of uncertainty in the posterior probability from the spatial GMM shows promise in addressing the primary clinical question of determining the …
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Influence of the Vitamin D3 Analog EB 1089 on Senescence and Cell Death Pathways in the Response of Breast Tumor Cells to Ionizing Radiation
… of proliferative capacity is observed in MCF-7 breast tumor cells exposed to fractionated radiation (5 x 2Gy) alone. Exposure to the vitamin D3 analog EB 1089 (100nM) prior to irradiation converts the initial growth arrest response to cell death in part through the inhibition of …
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A New Breast Cancer Image Classifier Using Gaussian Mixture Model Based on Histogram and Enhanced Roughness Index
<p>Early stage breast cancer detection is a critical challenge to improve survive rate, and thus it is extremely important to perform breast tumor image classification. In this thesis, a new method based on Gaussian Mixture Model (GMM) to perform the breast tumor classification into two different …
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Reprogramming the immune environment in breast cancer via dendritic cells.
Breast cancer is the most common cancer among American women. The current therapies are not curative for some forms of breast cancer, especially breast cancers that do not express the growth factor and hormone receptors and metastatic cancers. Recently, immunotherapy become an anticipated option …
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