Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"breast cancer therapeutics"”.
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Translational development and mechanistic insights into 3-(4- hydroxyphenyl)indoline-2-ones as a potent class of breast cancer therapeutics
Cancer research and therapy have seen major developments in recent decades with the paradigm of surgery/radiotherapy/chemotherapy advancing towards selective small molecules, biologics, immunotherapy, and other targeted therapies. Small molecule drug development remains an important cornerstone of …
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Elucidating Isoform Specific Roles of Calpain-1 and Calpain-2 in Breast Cancer
Breast cancer is the most frequently diagnosed women’s cancer in Canada. Average patient survival rates are high, but they are significantly reduced for those patients whose cancer reaches stage IV – metastatic disease. This study investigated the roles of calpain-1 and calpain-2 in metastatic …
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Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
Breast cancer remains a leading cause of mortality worldwide, driving the search for novel therapeutic compounds. Recent research has highlighted the transient receptor potential vanilloid 1 (TRPV1) ion channel as a promising target for cancer treatment. This study explores the antiproliferative …
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An investigation into the role of TBX3 in breast carcinogenesis and its regulation by the TGF-?1 signalling pathway
Cancer is the second leading cause of death among both men and women and accounts for 13% of total deaths worldwide. Enormous efforts have therefore been made to cope with this problem, but unfortunately limited success has been achieved with most of the current therapeutic strategies. The T-box …
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rRNA transcription as potential therapeutic target in triple negative breast cancers
Cancer has been identified as a group of diseases characterized by abnormal cell growth. In eukaryotic cells, the nucleolus is the region of the nucleus where initial stages of ribosome production occur. These stages include synthesis of ribosomal RNAs by RNA Polymerase 1 (RNAP1) followed by its …
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Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy
… crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small …