Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"breast cancer susceptibility gene 1"”.
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Identification and Characterization of Novel Kinases that Regulate BRCA1 Expression and Function
Transcriptional and functional regulation of the breast cancer susceptibility gene 1 (BRCA1) in the pathogenesis of sporadic breast cancers is poorly understood. We developed a functional assay, which assesses the ability of BRCA1 to localize to sites of DNA damage and form ionizing …
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Roles and Mechanisms of H3.1K27me1 Methyltransferases in Defense Against Virus in Arabidopsis
… compared to those in Col-0. Mutations of FAS2 or genes encoding H3.1 resulted in reduced H3.1 and H3.1K27me1 but failed to mimic the suppression of viral DNA replication observed in atxr5 atxr6. Mutations of METHYL-CpG BINDING DOMAIN PROTEIN 9 (MBD9) or Yeast SAC3 HOMOLOG B (SAC3B) in atxr5 atxr6 …
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Circadian modulation of the estrogen receptor alpha transcription
… number of disorders (e.g. jet lag, insomnia, and cancer). Period 2 (Per2), a circadian protein, is at the center of the clock's function. The loss or deregulation of per2 has been shown to be common in several types of cancer including breast and ovarian [1, 2]. Epidemiological studies established …
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Characterizing PIAS1 Function During Embryogenesis and Lung Cancer Progression
… enzymes in eukaryotes during embryonic organogenesis, tissue differentiation and human tumor progression; with a focus on non-small cell lung cancers (NSCLC). The SUMO E3 ligase protein inhibitor of activated STAT-1 (PIAS1) is one the few known SUMO conjugating enzymes known to date. PIAS1 was …