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Showing 1 to 8 of 8 for “"breast cancer stem cells"”.
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Role Of d16HER2 Splice Variant In Breast Cancer Stem Cells
… HER2 is overexpressed in about 20% of human breast cancers (BCs). Evidence suggests that the co-existence of the full-length/wild-type HER2 oncoprotein (WTHER2) with its altered isoforms increases the heterogeneity of HER2 overexpressing (HER2+) disease thus affecting its biology and …
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Microenvironmental Modulation of Breast Cancer Stem Cells Through Biological Matrix
<p> Breast cancer is the second leading cause of death among American women and almost 12.5% of the women are diagnosed with invasive breast cancer in the course of her lifetime. Recent advancement in breast cancer research has identified a rare, highly tumorigenic population of cells within tumors …
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Identification and Characterization of Her2/Neu-Transformed Breast Cancer Stem Cells
<p>A variety of human solid tumors, including breast cancer, are considered to embrace a hierarchical organization in which only infrequent tumor-initiating cancer stem cells are truly responsible for tumor formation rather than the non-tumorigenic majority. However, these cancer stem cells remain …
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Role of Polyphenolic Compounds in Chemoprevention of Breast Cancer Stem Cells
… to modulate key signaling pathways involved in breast cancer prevention. One noteworthy product, the Polyphenol-Enriched Blueberry Preparation (PEBP), produced by the fermentation of blueberries by the bacterium Rouxiella badensis subsp. acadiensis has demonstrated various beneficial properties, …
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Targeting tGLI1-positive Breast Cancer with Ketoconazole
… improvements in early detection and therapies, breast cancer remains the second leading cause of cancer-related death in women and the second most common cancer to metastasize to the brain. Current standard of care for breast cancer brain metastases (BCBM) involves surgical resection of …
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The Role of Ganglioside GD2 and GD3 Synthase (ST8SIA1) in the Regulation of Immune Suppression in Breast Cancer
… gangliosides influence the activity of immune cells including macrophages, NK cells, and T cells. GD3 synthase (GD3S) is the key enzyme that regulates the biosynthesis of the b and c series gangliosides, particularly GD3 and GD2, and studies have shown that GD3S is upregulated in most tumors …
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Molecular Mechanisms of Circulating Tumor Cell Adhesion in Breast Cancer Metastasis
During hematogenous metastasis, tumor cells dissociate from a primary tumor, migrate through the tissue space, and enter the circulatory system. The circulating tumor cells (CTCs), once bloodborne, travel to distant sites, where they adhere to the endothelial cells lining the vessel wall, …