Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 422 for “"breast cancer cells"”.
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Steroid receptor crosstalk in breast cancer cells.
Breast cancer is the leading cause of cancer related death in women, and approximately 1 in 11 women will develop breast cancer before the age of 75. In 2003, breast cancer was responsible for 16% of cancer related deaths in Australian women. This demonstrates that throughout the life span of the …
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Breast cancer cells cooperate during invasion and metastasis
Metastasis continues to be the leading cause of breast cancer-related deaths. Metastasis is a multistep process during which cancer cells leave the primary tumor, invade and seed inside secondary tissues, leading to lethal organ failure. Currently, no efficient method exists for the elimination of …
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Antitumor activity of antimalarials in human breast cancer cells
… we showed that quinidine arrested MCF-7 cells in G1 phase of the cell cycle and led to a G1 to G0 transition followed by apoptotic cell death (Wang et al., 1998). The present experiments demonstrate that MCF-7, MCF-7ras, T47D, MDA-MB-231, and MDA-MB-435 cells transiently differentiate …
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Understanding Acquired Resistance to Lapatinib In Breast Cancer Cells
… malignant transformation of mammary epithelial cells. ErbB family members are often over-expressed in human breast carcinomas. Lapatinib is an ErbB1 and ErbB2 tyrosine kinase inhibitor that has been shown to have anti-proliferative effects in breast and lung cancer cells. Cells treated with …
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Bioimpedance spectroscopy of breast cancer cells: A microsystems approach
… label-free means of monitoring biological cells and their responses to physical, chemical and biological stimuli. Breast cancer is the second most common type of cancer among women in the United States. Although significant progress has been made in diagnosis and treatment of this disease, …
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Mathematical Modeling of Therapies for MCF7 Breast Cancer Cells
Estrogen receptor (ER)-positive breast cancer is responsive to a number of targeted therapies used clinically. Unfortunately, the continuous application of any targeted therapy often results in resistance to the therapy. Our ultimate goal is to use mathematical modelling to optimize alternating …
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Effect of Estradiol on xc- in Human Breast Cancer Cells
<p></p><p>Breast cancer is the most common cancer among women worldwide with hundreds of thousands of new cases diagnosed each year in the United States alone. The discovery of receptors has improved the specificity of diagnoses, enabling development of receptor specific treatments. The discovery …
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Estrogen Receptor Dependent Gene Regulation in Human Breast Cancer Cells
… cellular functions including proliferation of breast cancer cells. These studies should assist in the development of novel targeted therapies for breast cancer prevention and treatment.
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The growth of murine breast cancer cells in dystrophic mice
The American Cancer Society predicted that 230,480 women would be diagnosed with, and 39,520 women would die from breast cancer (BC) in the United States in 2011. While the incidence of female BC has been decreasing, BC remains the second leading cause of cancer death among women in the United …
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Investigating The Effects of Silencing Epha2 In Metastatic Breast Cancer Cells
… kinase that is commonly over-expressed in cancers such as those of the prostate, colon, lung, and breast. For breast cancers, EphA2 overexpression is most prominent in the ER-negative subtype, and is associated with a higher rate of lung metastasis. Studies conducted to demonstrate the role …
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Cholesterol synthesis inhibitors prevent growth and metastasis of breast cancer cells
… and progestin (P) have an increased risk of breast cancer compared with women taking estrogen alone or placebo. Using animal models, we previously showed that both natural and synthetic P accelerate the development of breast tumors in vivo and increase their metastasis to lymph nodes. Our …
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Resveratrol Regulates IGF- II and Cathepsin D in Breast Cancer Cells
<p>Breast cancer is the most common type of cancer among women in the US. Phytoestrogen resveratrol (RS V) has been described as a potential ehemotherapeutic agent, but has been associated with breast cancer cell growth and cell death. RSV binds to estrogen receptors (ER) and functions as a mixed …
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Tunable Microchips for Imaging Protein Structures formed in Breast Cancer Cells
The breast cancer susceptibility protein, BRCA1, is a tumor suppressor that helps maintain genomic integrity. Changes in BRCA1 that effect DNA repair processes can fuel cancer induction. The Kelly lab, at the Virginia Tech Carilion Research Institute, has recently developed a new methodology that …
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Astaxanthin Decreases Invasion and MMP Activity in Triple Negative Breast Cancer Cells
… invasion and metastasis of triple-negative breast cancer (TNBC) cells. We determined that Astaxanthin decreases invasion of 4T1 cells through Matrigel<sup>TM</sup>, but does not affect proliferation. Using zymography we showed that 4T1 cells treated with Astaxanthin demonstrate decreased …
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Regulation of Breast Cancer Cells’ Bone-Metastatic Potential by Mechanically Stimulated Osteocytes
Bone metastasis, the migration of cancers to the bone, occurs in 65-75% of patients with advanced breast cancer and significantly increases patients’ morbidity and mortality. The bone-metastatic cancer cells interact with cells in the bone to disrupt the bone remodeling balance, causing reduced …
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Pharmacological regulation of c-myc gene expression in human breast cancer cells
… and inhibition of proliferation in MCF-7 human breast cancer cell line (Woodfork, K. et al., 1995). The goal of studies reported here was to understand the molecular mechanisms of c-myc gene regulation by quinidine. C-myc is one of the most common oncogene aberrations in breast cancers (Deming, …
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Effect of cmvIL-10 on Exosome Production by Human Breast Cancer Cells
… but has been implicated in several forms of cancer, including breast cancer. Breast cancer is the second leading cause of cancer related deaths in women in North America, usually from metastasis. Exosomes are 30-100nm vesicles produced by most cells which carry protein and RNA to cells in …
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Heat shock protein 27 inhibition of apoptosis in human breast cancer cells
Cancer occurs when normal cells fail to die in response to various cell death signals. Normal eukaryotic cells exhibit two major forms of cell death--Necrosis and Apoptosis. Apoptosis can be triggered in cells by various agents. Studies have shown that an elevated amount of Hsp 27 protects cells …
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