Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"breast and ovarian cancer"”.
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Managing Susceptibility to Hereditary Breast and Ovarian Cancer
The recent identification of Breast Cancer 1 (BRCA1) and BRCA2 genes offers an opportunity for high-risk individuals to learn whether they may be genetically predisposed to develop breast and/or ovarian cancer. The purpose of this study was to examine how unaffected women, identified as BRCA …
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Estrogen-receptor-alpha-positive breast and ovarian cancer: Therapy and mechanisms
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Evaluating The Nccn Clinical Criteria For Hereditary Breast and Ovarian Cancer Syndrome Genetic Testing
<p>Hereditary Breast and Ovarian Cancer (HBOC) syndrome predisposes females with a <em>BRCA1</em> or <em>BRCA2</em> mutation to an up to 85% lifetime risk for breast cancer and an up to 40% lifetime risk for ovarian cancer. It is crucial for individuals with HBOC to be identified to allow for …
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Novel tools to identify estrogen regulated genes important for breast and ovarian cancer cell proliferation
… are steroid hormones produced by the ovaries and extra ovarian tissues including the adrenal gland and adipose tissue. There are 3 major physiologically relevant estrogens in the human body, the most potent and biologically relevant of which is 17 -estradiol (E2). E2 exerts its physiologic …
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The effect of distinct BRCA1 splice forms on drug sensitivity in breast- and ovarian cancer cell lines
… mutations in BRCA-genes cause higher risk of cancer development, particularly in breast and ovaries. PARP inhibitors are a promising treatment option for carriers of BRCA1/2 mutations diagnosed with these tumor types. Pathogenic spliceogenic variants have been found in BRCA1 that change the …
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CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS
<p>Lysophosphatidic acid (LPA) and transforming growth factor beta (TGFβ) are platelet-derived intercellular mediators of cell proliferation and motility. LPA is a general growth, survival and motility-stimulating factor in mammalian cells. TGFβ prevents proliferation of normal epithelial cells. …
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Factors Associated With Early Versus Late Development of Breast and Ovarian Cancer In Brca1 and Brca2 Positive Women
Hereditary breast and ovarian cancer (HBOC) is caused by a mutation in the BRCA1 or BRCA2 genes. Women with a BRCA1/2 mutation are at increased risks for breast and ovarian cancer and often develop cancer at an earlier age than the general population. However, some women with a BRCA1/2 mutation do …
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Perspectives and Experiences of Individuals Undergoing Predictive Testing for Hereditary Breast and Ovarian Cancer (HBOC) Syndrome in the Western Cape, South Africa.
Breast cancer is the most common malignancy affecting females globally. Hereditary breast and ovarian cancer (HBOC) syndrome is caused by pathogenic variants in BRCA1 and BRCA2 and is seen in approximately 50% of families with a strong history of breast and ovarian cancers. Predictive testing (PT) …
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Cancers Associated With Brca1 and Brca2 Mutations Other Than Breast and Ovarian
<p>Mutations in <em>BRCA1</em> and <em>BRCA2</em> cause tumor development in Hereditary Breast and Ovarian Cancer syndrome (HBOC) through accumulation of unrepaired DNA damage. Extensive research of <em>BRCA1</em> and <em>BRCA2</em> mutations has led to well-defined breast and ovarian cancer risks …
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The lived experiences of mothers regarding care of their hospitalised preterm babies
… to promote the well-being of both the mother and the baby, with proven positive effects on reduction of neonatal mortality and maternal health benefits, including parental sense of fulfilment and confidence in caring for the baby and reduction in breast and ovarian cancer. The findings of this …
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X chromosome studies and breast and ovarian carcinoma
… inactivation (XCI), X-linked gene overexpression and abnormal X content have been associated with breast and ovarian cancer. Partial or complete reactivation of the inactive X in females may be a step in breast and ovarian cancer progression, leading to overexpression of some tumour enhancing …
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From Naturally Occurring Tumor Immunity to Supernatural T Cells: Isolation and Characterization of a Murine T Cell Receptor Specific for Human Breast and Ovarian Tumor Antigen Cdr2
… response against a protein called cdr2 in their breast and ovarian carcinomas, and thus provide an innovative starting point for understanding how to harness the immune system to fight cancer. We previously demonstrated cdr2-specific cytotoxic T lymphocytes (CTL) in the peripheral blood of …
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Cancer Incidence In First and Second Degree Relatives of Brca1 and Brca2 Mutation Carriers
… genes are associated with increased risks for breast, ovarian, and several other cancers. The purpose of this study was to evaluate the incidence of cancers in first and second degree relatives of <em>BRCA</em> mutation carriers compared to the general population. A total of 1086 pedigrees of …
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Breast Cancer Risk For Female Relatives of Male Breast Cancer Patients With Negative Brca1/2 Testing
… exist to estimate a female’s lifetime risk of breast cancer in the absence of a hereditary predisposition to cancer, namely Hereditary Breast and Ovarian Cancer syndrome. These risk models consider various factors such as reproductive history and family history, but few models take a family …
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Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery
… (CPPs) containing arginine (R), tryptophan (W), and histidine (H) have been promising for siRNA delivery. Therefore, to enhance siRNA delivery and efficient silencing of the STAT3 gene, herein, we hypothesized to use of fatty acylation with oleyl chain to our newly designed cell-penetrating …
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Blame it on her genes : on performativity, politics, and the consumption of prevention
… thesis examines the politics of performativity and its effects in everyday life. The context of the study is the practices surrounding the consumption of preventive solutions for hereditary breast and ovarian cancer, and a specific set of genes, the BRCA genes, which are associated with an …
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Characterization and therapeutic evaluation of a traumatic brain injury model in compliance with common data elements
… It represents the leading cause of morbidity and mortality in children and young adults, resulting in long- term sequelae for a considerable number of survivors. Development of effective therapeutics for patients with TBI is an unmet need. A critical step to address this need is to establish …
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Predictors of Contralateral Breast Cancer In Brca Negative Women
<p>Breast cancer is the most common cancer diagnosis and second leading cause of death in women. Risk factors associated with breast cancer include: increased age, alcohol consumption, cigarette smoking, white race, physical inactivity, benign breast conditions, reproductive and hormonal factors, …
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Characterization of the Paraneoplastic Cerebellar Degeneration Antigen Cdr2
… degeneration (PCD) is a remote effect of breast and ovarian cancer on the nervous system. It is believed to arise when these tumors ectopically express a neuron-specific protein, thereby initiating an anti-tumor immune response that subsequently develops into a neuronal degeneration. Three …
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Molecular Recognition At Dna Damage Sites
BRCA1 is frequently mutated in breast and ovarian cancer patients and it exerts its tumor suppressive function within several distinctive complexes by facilitating error-free DNA repair via homologous recombination (HR) mechanism. The particular focus of this dissertation is the BRCA1-RAP80 …
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