Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"breakage-fusion-bridge"”.
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Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
… which could explain the fact that anaphase bridges and multipolar mitoses were only observed in these tumour elements. Because of breakage-fusion-bridge cycles, chromosomal instability is associated with karyotypes with extensive structural chromosomal rearrangements. By applying a …
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Repetitive Sequences Drive Rapid Adaptation in Candida albicans
… antifungal drug, due to successive rounds of the breakage-fusion-bridge cycle and homologous repair. Importantly, we describe how removal from antifungal drug promotes rapid loss of the complex CNVs, resulting in the ancestral genotype and azole antifungal drug susceptibility These findings, while …
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Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia
… an abnormality<br/>that may have arisen from a breakage-fusion-bridge mechanism, possibly initiated<br/>by loss of a telomere. Results indicated that iAMP21 represents a distinct genetic<br/>subgroup of childhood ALL and is not secondary to a cryptic abnormality of<br/>chromosome 21. Two …
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Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes.
… amplification and the generation of chromosomal breakage-fusion bridge cycles and could confirm that MYCN amplification was associated with reduced tumour telomere length in vivo. We also found a possible association between poor survival and elongated telomeres, which needs to be studied …
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Neotelomere Formation by Telomerase in Human Cells
… crisis, dysfunctional telomeres undergo repeated breakage-fusion-bridge cycles, forming dicentric chromosomes that snap during mitosis. Ultimately, clinically detectable tumors emerge from this process with shuffled, aneuploid genomes after acquiring a telomere maintenance mechanism, usually by …
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Algorithms for analyzing complex structural variations in cancer genomes
… genomes to date. We analyzed two mechanisms, breakage-fusion-bridge (BFB) and tandem duplication (TD), for recurrent focal amplifications and found different frequently focal amplified regions have different enrichment of specific tumor types. We proposed a new pan-cancer classification …
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Negative feedback regulation as a means to constrain the oncogenic potential of mutant Egfr in NSCLC
… Egfr on chromosome 11, we attempted to initiate breakage-fusion-bridge (BFB) cycles in the lung, as these are thought to be a precursor to gene amplification. Our inability to elicit tumor formation using this strategy highlights the limitations in our understanding of how amplicons form in human …