Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"break-induced replication"”.
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The Molecular Mechanism of Break Induced Replication
DNA double strand break (DSB) is one of the most threatening of all types of DNA damages as it leads to a complete breakage of the chromosome. The cell has evolved several mechanisms to repair DSBs, one of which is break-induced replication (BIR). BIR repair of DSBs occurs through invasion of one …
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Human common fragile site FRA16D flexibility peak is not a strong mitotic: Recombination hotspot in <i>saccharomyces cerevisiae</i>
… sites (CFS) are areas of the genome that tend to break when DNA replication is stressed or partially inhibited. Breaks at CFS can lead to gene deletions and amplifications that can result in the genesis of cancer cells. There is controversy about the mechanism of CFS instability. This study …
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ROLE OF POLO KINASE CDC5 IN DNA DAMAGE PROCESSING AND REPAIR PATHWAY CHOICE.
… cerevisiae, nella riparazione di Double-Strand Breaks (DSBs). Per questo studio ho introdotto l’allele ipomorfico cdc5-T238A in ceppi in grado di riparare DSBs tramite meccanismi di riparazione unici. I dati raccolti dimostrano che l’attività chinasica di Cdc5 è fondamentale nella via …
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BETTING ON ALTERNATIVES: TARGETING TELOMERIC DILNCRNA AND BET PROTEINS IN ALT CANCER
… (ALT) pathway is a homology-driven, damage-induced mechanism of telomere maintenance (TMM) that sustains the proliferation of 10-15% of human cancers. We have recently discovered that damaged DNA, including deprotected telomeres, triggers de novo transcription of damage-induced long …
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Telomere Structure and Shortening in Telomerase-Deficient Trypanosoma brucei: Implications for Anitgenic Variation
… otherwise recognize them as double-stranded breaks. With the help of the ribonucleoprotein telomerase they compensate for the gradual sequence loss that would otherwise arise from the inability of conventional DNA polymerases to replicate chromosome ends. In Trypanosoma brucei, the causative …
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Mechanistic Understanding of the Role of TRF1 in Telomere Replication
… subunit TRF1 is important for facilitating the replication of telomeric DNA. Deletion of TRF1 results in several phenotypes that are thought to be associated with telomere replication stress, including ATR signaling, fork stalling, sister telomere associations, and fragile telomeres. Fragile …
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Role of ORCA/LRWD1 in the maintenance of telomere integrity
… integrity is maintained by the coordination of replication, heterochromatin, and DNA damage repair machinery. In this thesis, I describe how Origin Recognition Complex-associated (ORCA/LRWD1), regulates telomere integrity in Alternative Lengthening of Telomeres (ALT) -positive cells. In the …
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Accelerated Adaptation through Stimulated Copy Number Variation in Saccharomyces cerevisiae
Accelerated Adaptation through Stimulated Copy Number Variation in Saccharomyces cerevisiae Ryan Matthew Hull Repetitive regions of the genome, such as the centromeres, telomeres and ribosomal DNA account for a large proportion of the genetic variation between individuals. Differences in the number …