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Showing 1 to 20 of 94 for “"brain-derived neurotrophic factor (BDNF)"”.

  1. THE ROLE OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) IN THE HEALTH AND MAINTENANCE OF MOTORNEURONS

    Pomeroy, Emily J.2019

    nmu Repository record

  2. Region-Specific Expression of Brain-Derived Neurotrophic Factor (BDNF) mRNA after Long Term Treatment with Lithium Carbonate.

    유, 미영2011

    … ion may be mediated through regulation of brain-derived neurotrophic factor (BDNF). Recently, lithium ion has been shown to selectively protect spinal motor neurons in animal models of amyotrophic lateral sclerosis (ALS) by preventing the apoptosis component. In this study, investigation …

    ajou Repository record

  3. THE ROLE OF SKELETAL MUSCLE SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) ON THE HEALTH AND MAINTENANCE OF THE MURINE MOTOR UNIT

    Taisto, Mandy E2029

    … various myokines, including tumor necrosis factor alpha, IL-6, IL-8, IL-15, IL-17, and brain-derived neurotrophic factor (BDNF) (Pederson, 2011, So et al., 2014, Schnyder and Handschin, 2015). BDNF is a small neurotrophic protein, that regulates neuron differentiation, maturation, and …

    nmu Repository record

  4. Brain derived neurotrophic factor (BDNF): Untersuchungen zur Expression und Regulation in vitro sowie zur funktionellen Relevanz in der experimentellen autoimmunen Enzephalomyelitis (EAE)

    Demir, Seray2012

    Das Neurotrophin Brain derived neurotrophic factor (BDNF) ist essenziell für die Entwicklung und den Erhalt des Nervensystems. Seine Expression ist nicht nur auf Neuronen begrenzt, sondern wurde auch in Immunzellen, wie z.B. in den Infiltraten in Multiple Sklerose Läsionen, detektiert. Zahlreiche …

    goettingen Repository record

  5. Die Konzentrationen von Brain-Derived-Neurotrophic-Factor (BDNF) und Neurotrophin (NT 3) in humanem Hirngewebe bei der Demenz vom Alzheimer-Typ und Psychosen aus dem schizophrenen Formenkreis

    Michel, Tanja MariaUniversität Würzburg

    … stand zur Diskussion, ob es zu Veränderungen der BDNF- und NT 3-Konzentrationen in verschiedenen Gehirnregionen von Patienten mit DAT bzw. schizophrener Psychosen verglichen mit neuro-psychiatrisch unauffälligen Personen kommt, und darüber hinaus, ob diese ursächlich an der Entstehung dieser …

    wurz-thes Repository record

  6. NICOTINE WITHDRAWAL AND DEFICITS IN COGNITIVE FLEXIBILITY: POSSIBLE TIES TO ABERRATIONS IN FRONTOSTRIATAL BDNF SIGNALING

    Cole, Robert DavidTemple University. Libraries2017

    … are critical for cognitive flexibility and brain-derived neurotrophic factor (BDNF) modulates glutamate plasticity, we also explored the effects of nicotine withdrawal on these neurochemical substrates. Adult male C57BL/6J mice were trained in an operant task that required the animals to …

    temple Repository record

  7. EPIGENETIC REGULATION OF MICROGLIAL PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS

    GENEVIEVE SAW TSE JING2020

    … element binding protein (CREB) and ultimately brain-derived neurotrophic factor (BDNF) expression, shown to be involved in neuronal LTP. Microglial PI3K was also found to be post-translationally regulated through sumoylation. Electrophysiological recordings in rat hippocampal slices show the …

    nus Repository record

  8. Nicotine Sensitization in a Rodent Model of Schizophrenia: A Comparison of Adolescents, Adults, and Neurotrophic Factors.

    Perna, Marla Kay2007

    … to nicotine than controls given nicotine. Brain-derived neurotrophic factor (BDNF) was analyzed in the nucleus accumbens. BDNF was significantly increased in nicotine treated adolescent females but was not affected in males. Nicotine alleviated BDNF deficits in D2-primed adults. These …

    etsu Repository record

  9. Truncated Tyrosine Kinase Receptor B (TrkB.T1) plays a role in susceptibility to chronic stress

    Khalaf, SaraCarleton University2020

    Brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) have been implicated in depressive/anxiety disorders. The efficacy of antidepressants may be related to BDNF-TrkB signaling fueling neuroplastic changes. TrkB.T1 might have novel signaling effects that may be relevant for dealing …

    carleton Repository record

  10. Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced by Neonatal Quinpirole Treatment.

    Thacker, Stephanie K2005

    … that were alleviated by olanzapine treatment. Brain tissue analysis revealed that D<sub>2</sub>-primed animals demonstrated a significant decrease in the neurotrophins nerve growth factor (NGF) in the hippocampus and brain-derived neurotrophic factor (BDNF) in the frontal cortex. Olanzapine …

    etsu Repository record

  11. Vliv úpolových aktivit na hladinu irisinu a BDNF v krvi u seniorů nad 65 let

    Holá, VeronikaUniverzita Karlova, Fakulta tělesné výchovy a sportu2025

    … of neuroprotective exerkines, such as irisin and Brain-Derived Neurotrophic Factor (BDNF). This study focuses on analyzing the effects of martial arts on the levels of these substances, synaptic plasticity, and neuroprotection in seniors over the age of 65. Additionally, it investigates the impact …

    charles-prague Repository record

  12. Regulation of Brain-Derived Neurotrophic Factor in the Adult Mouse Brain

    Malkovska, Irena2010

    In the adult central nervous system (CNS) brain-derived neurotrophic factor (BDNF) has been implicated in neuroprotection and synaptic plasticity among other functions. However, relatively little is known of its regulation. In this thesis, we attempted to learn more about BDNF regulation by means …

    utswmed Repository record

  13. THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE

    Benson, Sydney2025

    <p>Brain derived neurotrophic factor (BDNF) is a neurotrophin essential to neuron health and maintenance in both the central nervous system and periphery. It acts as a positive feedback system for the body’s motor neurons and the muscles they innervate, strengthening the synapse between them. …

    nmu Repository record

  14. THE MOLECULAR AND BEHAVIORAL CHARACTERIZATION OF THE MURINE CRE – LOXP SKELETAL MUSCLE SYNTHESIZED BDNF KNOCKOUT MODEL

    Rustad, Asha E2025

    <p>Brain derived neurotrophic factor (BDNF) is a neurotrophin essential for supporting the growth, differentiation, and health of neurons within the central and peripheral nervous systems. BDNF is also a member of the myokine family, where muscle synthesized-BDNF (msBDNF) is thought to facilitate …

    nmu Repository record

  15. THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN DERIVED NEUROTROPHIC FACTOR IN THE MAINTENANCE OF MOTOR NEURON MITOCHONDRIAL POPULATIONS

    Cawley, Mikel2020

    … of progressive pathology may be a reduction in brain-derived neurotrophic-factor (BDNF) signaling at the motor unit. We have shown that mice deficient in skeletal muscle-synthesized BDNF (msBDNF) demonstrate progressive motorneuron and muscle pathology at 120d. We hypothesize mitochondrial …

    nmu Repository record

  16. An Assessment of Frontal Lobe Activity and BDNF Levels Following Concussion in Collegiate Athletes: A Near-Infrared Spectroscopy Study

    Kangas, Keara2019

    … related injuries, can result in a mild traumatic brain injury (mTBI), known as a concussion. Previous research has assessed how mTBIs affect the brain, but these assessments are limited in their ability to directly measure the consequences of mTBI. Along with concussion assessments, only a few …

    nmu Repository record

  17. THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE

    Brandt, Ryan2019

    <p>BDNF homozygous floxed mice (BDNF<sup> lox+/+</sup>) are a transgenic mouse strain used to study the neurotrophin brain-derived neurotrophic factor (BDNF) through Cre-Lox recombination when crossed with the appropriate Cre-expressing strain. BDNF<sup> lox+/+</sup> mice contain two artificially …

    nmu Repository record

  18. THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR IN RETROGRADE TRANSPORT ALONG MOTORNEURON AXONS

    Dangremond, Rebecca L2016

    <p>Brain-derived neurotrophic factor (BDNF) is a neurotrophin required for the differentiation, growth, and survival of neurons. BDNF is synthesized in several tissue types including skeletal muscle. Neuromuscular diseases (NMDs) are characterized by the degeneration of motorneurons and/or …

    nmu Repository record

  19. The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells

    Chirimuuta, Fungai Natalie WinnieUniversity of Birmingham2010

    … and the (common) low affinity, tumour necrosis factor receptor member, p75NTR. FDC-like cell lines were also analysed for neurotrophin component expression. This was to question FDCs as potential providers of paracrine neurotrophin signalling to Burkitt’s lymphoma B cells. Neurotrophin and …

    birmingham Repository record

  20. BDNF and Astrocyte TrkB.T1 Signaling as a Mechanism Underlying Astrocyte Synapse Interactions in Motor and Barrel Cortex

    Pinkston, Beatriz T. CejaVirginia Tech2024

    … the fundamental units of communication in the brain, and their proper development and function are critical for cognitive processes and behavior. While the development of glutamatergic synapses has been extensively studied, the mechanisms underlying the formation of the tripartite synapse …

    vt Repository record

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