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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 140 for “"brain tumors"”.
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Experimental brain tumors, dendritic cells and immunotherapy
… astrocytomas are the most common primary tumors of the adult central nervous system. Surgical resection of tumor mass in combination with radiotherapy and chemotherapy is only palliative and there is a clear need for new and more effective therapeutic strategies. The aim of this study was …
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Stem cell based therapy of malignant brain tumors
Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. The aims of the present thesis have been to develop and explore a stem cell …
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Immunotherapy against malignant brain tumors - of mice and men
… is the most abundant and most aggressive primary brain tumor in adults. Due to the infiltrative growth of the tumor, surgery will never be radical. Radiation and chemotherapy only marginally improve the poor prognosis due to the ability of the GBM to develop resistance towards these treatments. …
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Combined chemotherapy and immunotherapy against experimental malignant brain tumors
… the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. One possible therapeutic treatment …
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Treating MTAP-Deficient Brain Tumors with Purine Synthesis Inhibition
<p>Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Exploiting MTAP …
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Effects of Concurrent Radiosensitization and Chemoradiotherapy for Brain Tumors
… the most malignant and most common primary brain tumor in adults, with a median overall survival of only 15 months. This bleak outcome is partly due to the high chemoresistance and high radioresistance of glioblastoma. Current standard of care includes surgical resection, chemotherapy and …
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Bispecific Ligand Conjugate Immunotherapy of Choroid Plexus Brain Tumors
… cancers. Application of this design includes all tumors that express folate receptors, but additional ligands may be used to target other tumor varieties.
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Survivors Of Pediatric Brain Tumors: Psychosocial Outcomes And Executive Function
Children treated with CNS-directed therapy for brain tumor (BT) are at significant risk for developing late effects secondary to both disease and treatment. Executive functions (EF) encompass those skills necessary for appropriate problem solving and other goal-directed behaviors. Although no …
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Utilizing the Immunomodulatory Effects of Electroporation for Treating Brain Tumors
Brain tumors are among the most devastating types of solid tumors to treat. Standard of care for glioblastoma (GBMs), the most aggressive form of primary brain tumors, has failed to improve the current survival rates in the past decades. Despite many other solid tumors, recent advances in cancer …
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Characteristics of Individuals Undergoing Panel Genetic Testing For Primary Brain Tumors
… testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution. Our aim was to describe patient-specific characteristics and family histories across …
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Enhanced Delivery of Gold Nanoparticles with Therapeutic Potential for Targeting Human Brain Tumors
The blood brain barrier (BBB) remains a major challenge to the advancement and application of systemic anti-cancer therapeutics into the central nervous system. The structural and physiological delivery constraints of the BBB significantly limit the effectiveness of conventional chemotherapy, …
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Visualizing The Dynamics of Immune Surveillance In Brain Tumors By Intravital Multiphoton Microscopy
… the dynamics of immune surveillance in brain tumors by intravital multiphoton microscopy</strong></p> <p>By</p> <p>Felix I. Nwajei, MD</p> <p>Supervisory Professor: Tomasz Zal, Ph.D.</p> <p>Brain tumors (BTs) generally have a bad prognosis despite conventional treatment strategies. …
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Immunotoxin Monotherapy and Combinatorial Therapy With Immune Checkpoint Inhibitors for Malignant Brain Tumors
… is the most common and aggressive malignant brain tumor among all primary brain and central nervous system (CNS) tumors. The median survival time for glioblastoma patients given the current standard of care treatment (surgery, radiation, and chemotherapy) is less than 15 months. …
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Investigating circuit and spatial heterogeneity of human brain tumors with patient-derived organoid models
… glioblastoma (GBM), are aggressive adult primary brain cancers with dismal prognosis. Both malignant cell heterogeneity and the influence of myriad cell types present in the tumor microenvironment, such as neurons, contribute to glioma progression. This dissertation represents a multi-pronged …
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Synthesis, characterization and biological studies of carboranyl-porphyrin bioconjugates for treatment of brain tumors
<p>Chapter 1 gives a brief introduction to brain tumors, approaches to deliver drug across the blood brain barrier (BBB), boron neutron capture therapy (BNCT) for brain tumors, application of carboranyl derivatives in attempt to treat brain tumors using BNCT. Chapter 2 involves synthesis, …
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Evaluation of Adoptive T Cell Therapy and Oncolytic Virotherapy for Treatment of Brain Tumors
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2013-01-22T11:00:26Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Neuroscience Program Dissertations (ID: 630) No. of bitstreams: 3 Thomas_Diana.pdf.txt: 257425 bytes, checksum: …
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Investigations of Ultrasound-Guided Histotripsy Ablation for Soft Tissue Sarcomas, Osteosarcomas, and Brain Tumors
… investigations using histotripsy to ablate brain tumors are underway, but require advanced histotripsy devices capable of overcoming attenuation of the therapeutic ultrasound signal by the skull and rely on MRI for real-time guidance. As a result, open questions remain regarding …
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Magnetic Resonance Spectroscopy Imaging of 2-Hydroxyglutarate in Brain Tumors at 3T and 7T In Vivo
… outstanding strength for monitoring IDH-mutant tumors. The present work aims to develop new techniques that provide meaningful estimation of 2HG and other metabolites in gliomas in vivo. As the first topic, novel triple refocusing MRS was developed at 3T for improving the 2HG signal sensitivity …
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