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Showing 1 to 20 of 28 for “"brain trauma"”.
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Monitoring brain neurochemistry after brain trauma
… real-time monitoring of cerebral metabolites in traumatic brain injury (TBI) patients. Through a series of in-vitro and in-vivo studies, this research addresses the critical need for enhanced sensitivity and specificity in brain metabolite monitoring. The integration of these sensors with …
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The correlation between cranial fractures and brain trauma: a retrospective study
Traumatic brain injury (TBI) is a global public health concern. TBI has been noted to co-occur with cranial fractures, however this is not always case. At present, there is a gap in literature regarding the correlative relationship between the presence of cranial fracture and brain trauma. The …
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Homing of 111In-Labeled Bone Marrow Mesenchymal Stem Cells in Acute Brain Trauma Model
… mesenchymal stem cells (BMSCs) in an acute brain trauma model by 111In-tropolone labeling and to perform the effect of 111In-labeling on the viability and functions of BMSCs. Rat BMSCs were labeled with 37 MBq 111In-tropolone. Their labeling efficiency and in vitro retention rate were …
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A Comparison of Brain Trauma Characteristics from Head Impacts for Lightweight and Heavyweight Fighters in Professional Mixed Martial Arts
… neurological consequences due to repetitive head trauma. Mass differentials as well as reported differences in fight styles between Lightweight and Heavyweight fighters in MMA may affect head impact kinematics creating different levels of head injury risk. Factors that influence the risk for head …
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On Brain Oedema
Traumatic brain injury and bacterial meningitis may at a glance appear as two different disease entities. The host reaction, however, to both trauma and infection involves a strong inflammatory response, with the classical symptomology of rubor, tumor, calor, dolor et functio laesa. Tumor, …
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Effect of Rule Changes Occurring Between 2003 and 2016 on Head Impact Frequency and Brain Strain Magnitude In North American Professional Ice Hockey
Head impacts can result in various levels of brain trauma, from mild to severe, and often result in long lasting effects on human brain function (McAllister & McCrea, 2017; Sollmann et al., 2018). Over the past two decades alone the National Hockey League (NHL) has made several rule changes to the …
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Novel Immune-Regulatory Mechanisms in a Mouse Model of Traumatic Brain Injury
Traumatic brain injury (TBI) is a major health concern in the United States and worldwide and effective treatment options are limited. Differences in the magnitude and characteristics of the peripheral-derived immune cell response to TBI are key contributors to the secondary cascades of damage …
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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms
… state. One of the major risk factors for AD is traumatic brain injury: TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in approximately 30% of human subjects following severe TBI. Intra-axonal accumulations of total and phospho-tau and less frequently NFTs have also been …
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Differences in brain architecture during long-term recovery following mild traumatic brain injury
Mild TBI (mTBI) is brain trauma from an external impact with a loss of consciousness less than 30 minutes. mTBI results in several biopsychosocial impairments with pronounced cognitive deficits, thought to resolve within three months of injury. Previous research suggests that these impairments are …
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A pilot study toward the development of ERD and SSVEP based hybrid brain computer interface
Brain-computer interfaces (BCI) are devices that allow for the brain to communicate information to a computer. In situations where a victim of brain trauma or disease has suffered damage causing paralysis or impaired movement, BCIs may be the answer in providing assistance to neurological function. …
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The Effects of Subconcussive Impacts on Postural Stability
… supporting late-life detriments due to brain trauma</p>
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Enzyme Analysis of Oxidatively Modified Proteins Post-TBI
<p>The brain is one of the most important organs in the body. It functions as a control center by regulating and coordinating actions and reactions, which is facilitated via signal transduction pathways. Its function is primarily dependent upon sufficient supply of glucose for energy metabolism. …
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Entry-based Planning of Neurosurgical Trajectories
Purpose In cases of brain trauma or hydrocephalus an external ventricular drain (EVD) is often inserted through the skull and brain to drain excess cerebrospinal fluid from the ventricles to relieve pressure. Most often, EVDs are inserted free-hand, without guidance, at a point on the skull named …
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Evaluation of the Protective Capacity of Ice Hockey Goaltender Masks for Three Accident Events using Dynamic Response and Brain Stress and Strain
… the introduction of helmets the incidence of traumatic brain injuries (TBI) in ice hockey has greatly decreased, but the incidence of concussions has essentially remained unchanged. Despite goaltenders in ice hockey being the only players on the ice for the entire game, few have assessed the …
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Pathological Upregulation of a Calcium-Stimulated Phosphatase, Calcineurin, in Two Models of Neuronal Injury
… neurological pathologies, status epilepticus and traumatic brain injury.Status epilepticus was induced by pilocarpine injection. NMDA-dependent increases in calcineurin activity were observed in cortical and hippocampal homogenates. Upon closer examination, the most profound increases in activity …
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Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI
<p>Disruption of blood-brain barrier (BBB) is a key secondary event that exacerbates brain damage following traumatic brain injury (TBI). BBB disruption is particularly damaging to the developing brain – which is highly vulnerable to various stress stimuli, resulting in increased brain swelling, …
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Cognitive and emotional effects of one season of head impact exposure in high school contact sport athletes
… damage as a result of sports-related brain trauma is a major concern for athletes today. In the last decade, studies of subconcussive repetitive head impacts (RHI) in contact sports have found associations with functional and structural brain changes, even in the absence of diagnosed …
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Contusion Progression in Traumatic Brain Injury
Cerebral contusions that result from brain trauma have the propensity to enlarge over the days following injury, including extension of the haemorrhage core and swelling of the surrounding peri-contusional brain. This secondary injury increases the likelihood of death and severe disabil- ity, and …
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Mtorc1 Signaling In Memory Formation and Dysfunction
… <p>It has been shown that in response to traumatic brain injury (TBI), mTORC1 activity is acutely increased, and treatment with rapamycin, a specific inhibitor of mTORC1, has been shown to improve outcome. On the other hand, chronic elevated levels of mTORC1 are required for axonal …
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Modeling and estimation for non-invasive monitoring of intracranial pressure and cerebrovascular autoregulation
Brain tissue is highly vulnerable to unbalanced oxygen demand and supply. A few seconds of oxygen deficit may trigger neurological symptoms, and sustained oxygen deprivation over a few minutes may result in severe and often irreversible brain damage. The rapid dynamics coupled with the potential …
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