Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"brain targeting"”.
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Novel gene delivery systems for brain targeting
Disorders of the central nervous system such as brain tumours, Alzheimer's disease, Parkinson's disease, Huntington's disease and others lead to a worst decline in the quality of life of patients. The possibility of using gene therapy for the treatment of these disorders is hindered due to the …
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Design and Synthesis of a Novel Neuroprotective Brain-Targeting Amylin Receptor Antagonist
… log P (-1.2 for AC253) and are not optimized for brain uptake. From the structure-activity relationship studies, we have designed a 16-mer analog (R16) from the N-terminal region of AC253 as a novel AmyR antagonist for better activity and blood-brain permeability. The goal of this study is to …
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Reconstructing Cross-Species Ancestral Adeno-Associated Viruses for Enhanced Gene Therapy Delivery
… penetrating biological barriers like the blood-brain barrier (BBB). Additionally, their broad and nonspecific tropism can translate into suboptimal cross-species transduction efficiency and potential toxicity, complicating the clinical transition from animal model to humans. These challenges …
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Supramolecular Structure-Enabled Delivery of Porphyrin to Glioblastomas Beyond the Blood-Brain Barrier
… surgery (FGS) are two promising modalities for targeting glioblastoma infiltrates and overcoming therapy resistance. However, the presence of an intact blood-brain barrier (BBB) within infiltrative tumor tissue restricts porphyrin delivery and, thereby, therapeutic efficacy. This thesis …
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A Transferrin conjugated nanoemulsion system for brain delivery of antiretroviral therapy
… because they cannot efficiently cross the blood-brain barrier (BBB). The goal of this study is to develop a new transferrin conjugated nanoemulsion system (Tf-NE) for antiretroviral medication delivery and evaluate its potential to cross the BBB. Nanoemulsions were prepared based on the solvent …
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Development of implantable devices for schizophrenia treatment
… by abnormal levels of neurotransmitters in the brain. One of the drugs that is commonly prescribed to treat schizophrenia is risperidone (RIS). This drug is administered through the oral route (e.g. tablets). Accordingly, the drug is exposed to first-pass metabolism and enzymatic degradation in …
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Nose to Brain Delivery of Therapeutic Agents
… and do not allow frequent administration. Brain targeting of drugs by intranasal route is a safe and noninvasive method of drug delivery which allows frequent administration and is certainly more patient compliant than the currently folloinvasive methods. In this study, the plausibility of …
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Nanocarriers for drug targeting and improved bioavailability
… mostly, on two main topics: - Drug delivery to brain - Nanosuspensions for different applications The objective of the first topic was the development of liposomes to which anti-TfR-monoclonal antibodies (Ox26) or lactoferrin was bounded to transport the selective NK3 receptor agonist senktide …
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Novel sustained release formulation of leveodopa-dendrimer conjugate
… to deliver a sustained amount of levodopa to the brain so that a constant level of dopamine is maintained at the dopamine receptor sites. Therefore, in this study a novel sustained release formulation of levodopa was prepared which efficacy was evaluated by measuring the extent/amount of AS …