Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"brain stimulation reward"”.
-
Nicotine withdrawal causes transient elevations in brain stimulation reward thresholds
… attenuates the motivation to respond for rewarding electrical brain stimulation. It has been proposed that such attenuation of brain stimulation reward reflects opponent-process depression of brain reward circuitry and underlies the dysphoric symptoms of drug withdrawal in humans. In the …
-
Effects of selective neurotensin receptor antagonists on responding for brain stimulation reward
Electrical stimulation of the medial mesencephalic central gray produces a strong rewarding effect, and laboratory animals can easily be trained to produce an operant response to obtain such a stimulation. Previous studies have shown that the rewarding effect of mesencephalic electrical stimulation …
-
Characterization of the synergistic effects of cocaine with lateral hypothalamic brain stimulation reward
Cocaine is powerfully rewarding in humans and lower animals. The brain stimulation reward paradigm offers an interesting tool with which to study the reward-relevant actions of cocaine. Cocaine potentiates the rewarding impact of brain stimulation; the stimulation is thought to exert its …
-
Mapping the substrate for brain stimulation reward : new approaches to an old problem
A major goal for research on brain stimulation reward (BSR) is the identification of the directly-activated ("first-stage") neurons subserving the powerfully rewarding effect produced by electrical stimulation of the medial forebrain bundle (MFB). This objective was addressed by combining …
-
Brain Stimulation Reward is Integrated by A Network of Electrically-Coupled GABA Neurons
… electric current to various diverse brain structures, the neural substrate of brain stimulation reward (BSR) has eluded identification since its discovery more than a half-century ago. We show that GABA neurons in the midbrain, hypothalamus and thalamus express connexin-36 (Cx36) gap …
-
Temporal integration in the neural substrate for brain stimulation reward : duration neglect and the peak-and-end model
… The "peak" model states that the most rewarding moment of the experience is recorded into memory, while the "peak-and-end" model asserts that remembered reward value is an averaging of both the "peak" reward and the reward value experienced at the end of the event. Both models also …
-
Electrical stimulation of reward sites in the ventral tegmental area of the rat increases dopamine transmission in the nucleus accumbens as measured by in vivo microdialysis
… during, and after 15-min periods of electrical brain-stimulation at sites in the ventral tegmental area (VTA) that supported intracranial self-stimulation (ICSS). In the first experiment, both ICSS and yoked-stimulation of the VTA evoked significant increases in extracellular concentrations of …
-
Effects of dopamine depletion in the nucleus accumbens on lateral hypothalamic self-stimulation in the rat
Considerable evidence implicates dopamine in brain stimulation reward. For example, dopamine antagonists or destruction of dopaminergic neurons reduce the reward effectiveness of medial forebrain bundle stimulation. Assessment of such effects is complicated by across-subject averaging and by motor …