Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"brain stiffness"”.
-
In vivo and in vitro guidance of developing neurons by mechanical cues
… and the spatiotemporal dynamics of embryonic brain mechanics, are still largely uncharacterised. Here, I have identified a role for tissue mechanics in embryonic axon guidance in vivo, using retinal ganglion cell (RGC) axon outgrowth in the developing Xenopus laevis optic tract (OT) as a model …
-
Myelination diseases of the central nervous system: Artificial Axons as in vitro models of chemomechanical cues
… between demyelinating diseases and changes in brain stiffness, axon diameter, and axon density. An open question is whether these biophysical changes simply act as correlative biomarkers or contribute directly to disease progression. We demonstrate that the extent of myelin ensheathment by rat …
-
The brain microenvironment and its role in oligodendrocyte progenitor cell ageing
… changes in molecular interplay between the brain extracellular matrix (ECM), oligodendrocyte progenitor cells (OPCs) and astrocytes. During ageing the resident brain progenitors undergo cellular arrest causing a diminished regenerative response. Increasing research evidence supports the …
-
Imaging the local mechanical properties of the brain with high-resolution magnetic resonance elastography
Mechanical properties of the human brain reflect the composition and organization of the complex tissue microstructure. Neurodegeneration involves alteration of this microstructure through a number of processes including neuronal cell death; glial matrix disruption and demyelination; and …