Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"brain repair"”.
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Targeting autophagy for improving stem cell function in brain repair
… have documented the presence of autophagy in the brain which is activated as a result of cell stress following stroke. Aside from intravenous (i.v.) tissue plasminogen activator (tPA), there is no current cure or treatment for stroke. As a result, this study aims to target autophagy in neural stem …
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Understanding the role of dMob4 in postembryonic Neural Stem Cell mitotic reactivation
Brain homeostasis supports cognition and neural plasticity, the brains’ ability to adapt to its environment throughout life. These processes rely on replenishment from stem cells in the brain, termed Neural Stem Cells (NSCs). In the adult brain, most NSCs exist in a quiescent state and must …
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Molecular and cellular mechanisms of cortical functional regeneration through diterpenoid-induced neurogenesis
… neurogenesis as a therapeutic mechanism for brain repair. Among the neurogenic niches of the adult brain, the subventricular zone (SVZ) responds to cortical injury by generating neuroblasts that attempt to migrate toward the damaged area. However, most fail to reach or integrate into the …
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Towards an understanding of the role of Ca2+ signalling in neural stem cell activation
Regeneration of the adult human brain is a long time clinical challenge. The adult mammalian brain contains neural stem cells (NSCs) that are capable of brain repair, but they are mostly in a mitotically quiescent state. Identifying novel regulators of neural stem cell quiescence will provide more …
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Metabolic control of neural stem cell function in a patient-derived model of multiple sclerosis
… by a substantial failure of the main endogenous brain repair mechanism seen in the early stages of the disease. During this period, patients experience a gradual accrual of neurological deficits, which are largely attributable to neuronal loss. There are limited treatment options for this phase …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
During brain and spinal cord development majority of the cell types are produced by the multipotent, self-renewing and proliferating neural stem/progenitor cells (NSCs) through the processes like neurogenesis and gliogenesis [1]. In the developed mammalian brain these NSCs have been found to be …
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Analysis of Therapeutic Effect after Human Mesenchymal Stem Cell Transplantation in Ischemic Stroke Rat
… were higher in earlier-passage MSC-treated brains than in control or later-passage MSC-treated brains (P<0.01 in all cases). This study indicated that ischemia-induced neurogenesis was enhanced by the intravenous administration of human MSCs. The effects were more pronounced with …
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Exploring a Nuclear Insulin Receptor Signalling Pathway in Drosophila Neural Stem Cells
… turn may guide future therapeutic strategies for brain repair and difficult‐to‐treat malignancies. In this thesis, nuclear insulin signalling in *Drosophila* NSCs is studied via a variety of *in vivo* methods. Cyan fluorescent protein (CFP)‐tagged InR was expressed with the GAL4 system to examine …
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The Brain Invaders: Widespread Neuronal Dispersion in Developing and Adult Mammalian Brain
… is the principal determinant of the final brain cytoarchitecture. However, we have only limited knowledge about the migratory pathways and mechanisms utilized during brain development. In my thesis I present new and unexpected findings about neuronal migration in the developing forebrain. I …