Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"brain organoid"”.
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MICROGLIA-SUFFICIENT BRAIN ORGANOID
Embryonic primitive macrophages colonize the brain where they differentiate into microglia. Microglia were shown to contribute to brain development in animal models but their roles in human brain development remain poorly understood due to the lack of tissue access. The generation of brain …
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Comparative studies of brain developmental timing and progression using 3D stem cell models
The human brain is three times larger than those of our closest evolutionary relatives such as chimpanzees and gorillas, yet the mechanisms by which this increase in size has been achieved, and also the implications of this on human brain function and capabilities, remain largely yet to be …
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Human Brain Organoids for Studying Malignant Cell States and Intercellular Communication in Human Glioma
… of the disease. In recent years, human brain organoids have emerged as promising 3D, in vitro model systems for partially recreating the cellular composition and function of the human brain. In the context of this research, human brain organoids represent a potential construct through …
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INVESTIGATING THE ROLE OF FEZ1 IN EARLY HUMAN BRAIN DEVELOPMENT USING CEREBRAL ORGANOIDS
… seek to determine function of FEZ1 during early brain development by human cerebral organoids model and loss of function study. Transcriptome analysis revealed genes associated with neuronal development and synaptic function were differentially expressed in FEZ1 knockout organoids, suggesting …
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THE INTERPLAY BETWEEN ENDOCRINE DISRUPTION AND GENETICS IN THE PHYSIOPATHOLOGY OF HUMAN NEURODEVELOPMENT: BRIDGING EPIDEMIOLOGY TO MOLECULAR INSIGHTS THROUGH BRAIN ORGANOIDS AND HIGH RESOLUTION OMIC MODELLING
… pluripotent stem cells (hiPSC)-derived cortical brain organoids (CBOs), a model that recapitulates salient species-specific features of human brain development in a 3D microenvironment characterized by stereospecific interconnections among different cell populations. After chronically exposing …
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THE EVOLUTION OF THE MODERN CONDITION THROUGH THE LENS OF NEURODEVELOPMENT DIVERSITY: INSIGHTS FROM A PARADIGMATIC REWIRING OF GENE REGULATION
… reconfigured during the evolution of the Sapiens brain. Understanding how regulatory changes reconfigured the neurodevelopmental trajectories that underpin hallmark features of our species’ unique cognitive abilities requires the integration of computational and experimental approaches, pairing …