Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"brain network"”.
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Brain network modularity predicts cognitive flexibility
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Computational Principles of Brain Network Development
Brain development can be viewed through many lenses and studied at many scales. However, multiple theoretical perspectives have argued that brain organisation develops via competitive interactions between its constituent units, dynamically over time. In this thesis, I focus on modelling these …
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Development Of Human Brain Network Architecture Underlying Executive Function
… to adulthood is characterized by refinements in brain structure and function that support the dynamic control of attention and goal-directed behavior. One broad domain of cognition that undergoes particularly protracted development is executive function, which encompasses diverse cognitive …
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Elucidating the Principles of Brain Network Organisation through Neurosurgery
Recently, leaders in human brain mapping and the clinical neurosciences outlined the need for prospective trials in neurosurgery to establish the clinical relevance of connectomics. This doctoral dissertation addresses this challenge by using diffuse gliomas as a model to study the principles of …
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Brain Network Connectivity in Anaesthesia and Disorders of Consciousness
… pursuit. However, technological developments in brain imaging have allowed the study of consciousness as a natural, neurobiological phenomenon. The neurobiology of consciousness has been studied using cognitive and behavioural testing in healthy volunteers and by examining how brain function and …
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On the origins of glioma: insights from brain network mapping
Glioma tumours are among the most lethal brain disorders, claiming the lives of thousands of people in the United Kingdom each year. Despite the severity and prevalence of the condition, remarkably little is understood about the origins of gliomas, or the mechanisms that guide their spread within …
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FORMATION, REFINEMENT, AND REORGANISATION OF COMPLEX BRAIN NETWORK TOPOLOGY ACROSS THE LIFESPAN
Large-scale connections in the brain are organised in complex patterns. The unique distribution of connections across the whole brain is related to important cognitive, behavioural and mental health outcomes. In this thesis, I examine how the organisation of these connections form and changes …
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Development of novel multidimensional pattern-based EEG/MEG connectivity methods and their application to investigate the semantic brain network
… methods are key to understanding how brain regions interplay to perform complex cognitive processes. Yet, most current connectivity methods summarise activity within brain regions to unidimensional measures, resulting in a loss of information. Only recently, new functional connectivity …
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A Window to the Mind: Validation of a New Method to Measure Thought Dynamics Using Brain Network Meta-State Transitions
… and at rest. I began with a representation of brain activity at each timepoint as the set of activations across 15 networks, and used new methods to embed this high-dimensional network representation onto a two-dimensional space of possible network configurations (network meta-states). …
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Neuronal FMRP: facilitating learning in a critical brain network for zebra finch song acquisition and regulating synaptic miRNAs spatio-temporally
… that shows expression of the zebra finch FMRP in brain regions critical for normal song learning. Furthermore, I show that this expression is variable across development, supporting the argument for a role of FMRP in song learning. Moreover, I show that this variable expression is not due to …
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DYNAMIC FUNCTIONAL CONNECTIVITY NETWORKS: NEW ANALYSIS AND INTERPRETATION STRATEGIES
Traditional brain network studies have implicitly assumed that functional connectivity between distinct brain regions is static over the recording period of resting state scans. Brain network organization must dynamically recognize, integrate and respond to internal and external stimuli across …
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Self-Regulatory Brain Networks of Eating Behavior
… purpose of this thesis was to elucidate a brain network of self-regulatory failure among older adults predictive of real-world weight loss.
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Time-resolved Resting-state fMRI of Brain States Associated with Drug-resistant Epilepsy
… imaging (fMRI) data with the aim of elucidating brain patterns of aberrant activity in individuals with drug-resistant epilepsy. Specifically, a dynamic functional connectivity analysis method is first used to determine the temporal dynamics of brain activity, followed by two unsupervised machine …
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The Measure and Meaning of Structural Similarity in the Brain
… and often-overlooked organizing principle of brain network structure. At the same time, recent advances in structural MRI analytics have enabled large-scale mapping of anatomical similarity within individual brains. However, key questions remain that limit the current applicability and …
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Cognitive energetic mechanisms and neural basis of alertness regulation
… The third experiment (Study 3) investigated the brain network subserving alertness regulation - independent of the sensory modality of the response signals. We used functional magnetic resonance imaging to measure brain activity during simple reaction-time performance in tasks with auditory, …
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Development of human functional and structural brain networks in adolescence and its relevance to psychiatric disorders
The human brain undergoes various phases of active development during the lifespan. While these neurodevelopmental processes are fundamental to the emergence of new cognitive and social capacities, they also coincide with a period of increased risk of neuropsychiatric disorders, which generally …
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Clustering Methods for Network Adjacency Data
… to detect the topological community-structure of networks (connected graphs with n vertices and m edges), and studies inherent relations behind partitions. In this thesis, we consider far-reaching model-free clustering algorithms including Girvan and Newman’s edge betweenness algorithm, Zhou’s …
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Topology matters: characteristics of functional brain networks in healthy subjects and patients with Epilepsy, Diabetes, or Amyotrophic Lateral Sclerosis during a resting-state paradigm.
The brain can be seen as a complex structural and functional network. Cognitive functioning strongly depends on the organization of functional brain networks. EEG/MEG resting-‐state functional connectivity and functional brain networks studies attempt to characterize normal brain organization as …
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Reality Resists Classification: A Transdiagnostic, Network-Based Approach to Behavioural and Neural Variation in Childhood
… with the structure and function of the brain. These features of neurobiology are shaped concurrently by genetic factors, individuals’ interactions with the environment, and stochastic effects that instantiate divergent trajectories of development over time. Some behavioural and cognitive …
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Insights into brain networks from functional MRI and graph analysis during and following attentional demand
The human brain is a highly flexible and adaptive information processing system that allows us to interact with our environment and to adjust behaviour to current task demands. However, if a task demand is high, the flexibility and capability of the brain to adapt is challenged. The studies of the …
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