Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"brain neoplasms"”.
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Local drug delivery for treatment of brain tumor associated edema
Brain tumor associated edema, a common feature of malignant brain neoplasms, is a significant cause of morbidity from brain tumor. Systemic administration of corticosteroids, the standard of care, is highly effective but can introduce serious systemic complications. Agents that inhibit the vascular …
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Analysis of markers of cell division cycle, apoptosis and autophagy flux in glioblastoma
… most aggressive and most common type of primary brain neoplasms and are associated with poor prognosis despite advances in surgical and oncological treatments. Currently available treatments include surgical resection, fractionated external beam radiotherapy and chemotherapy. This study aimed to …
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Medulloblastoma : treatment and survival in HUS- area
Medulloblastom (MB) är den vanligaste maligna hjärtumören inom pediatrin och omfattar 63% av intrakraniella embryonala tumörer hos barn. Insidensnivån ligger globalt kring 0.7 fall per 100 000 invånare och medianåldern för diagnosen är 6 år. Tumören ligger i den bakre skallgropen och kan …
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Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems
Glioblastoma multiforme (GBM) are deadly brain tumors that are refractory to radiation and chemotherapy. Despite decades of work, little progress has been made in improving patient outcomes. Recent mapping of the GBM genome by the Cancer Genome Atlas Network revealed that these cancers commonly …
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Neural Stem Cells in Brain Tumor Development
… astrocytomas are highly invasive and incurable brain tumors. Mouse models that genetically resemble the human disease are valuable tools in understanding the pathogenesis of these malignancies. We previously reported mouse models based on conditional inactivation of the human …
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Late Effects of Hypothalamic Radiation Exposure in Pediatric Brain Tumor Survivors
BACKGROUND: Brain tumors are the second most common childhood malignancy and overall survival rates exceed 70%. Pediatric brain tumor survivors treated with hypothalamic radiation are at increased risk for developing components of metabolic syndrome, characterized by central obesity and two of the …
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Multimodality Imaging of Tumor Vasculature and Metabolism
… permeability in a mouse model of breast cancer brain metastases. Using a 9.4T system, high resolution anatomic MRI and dynamic susceptibility contrast (DSC) perfusion MRI were acquired at different time points after an intracardiac injection of brain-tropic breast cancer MDA-MB231-BR-EGFP …
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Advancing Radiotherapy Treatment Through Artificial Intelligence-Driven Approaches
… firstly developed for SRS patients with multiple brain metastases (mBMs). This platform can automatically segment out mBMs and auto-label each segmentation with an atlas label in high accuracy compared with manual contours and labels. Secondly, a deep-learning and radiomics ensemble classifier was …
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Magnetic Resonance Spectroscopy Imaging of 2-Hydroxyglutarate in Brain Tumors at 3T and 7T In Vivo
The identification of 2-hydroxyglutarate (2HG) by 1H magnetic resonance spectroscopy (MRS) in patients with isocitrate dehydrogenase mutant gliomas is a significant breakthrough in neuro-oncology imaging. 2HG is the first imaging biomarker that is specific to a genetic mutation in gliomas, making …
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Quantitative Non-Contrast Perfusion Measurements Using Arterial Spin Labeled MRI: Evaluation of Therapy Response in Brain Tumors and Technical Advancements in Kidneys
… perfusion, proven to be especially valuable in brain imaging. Despite these advantages, ASL has not undergone robust and rigorous validation as a quantitative imaging method for evaluating cancer therapy response. We hypothesize that robust and highly reproducible ASL-measured perfusion serves …