Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"brain metastases"”.
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OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE
… pathogenesis and immune regulation of melanoma brain metastases (MBMs).</strong></p> <p><strong> </strong>The functional significance of OXPHOS was assessed through genetic inhibition, involving knockout (KO) of key regulatory genes such as <em>Ppargc1a </em>(PGC1a) and <em>Ndfus4 </em>(NDUFS4), …
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Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases
<p>Melanoma brain metastases (MBMs) are diagnosed in up to 60% of metastatic melanoma patients. Previous studies have identified clinical factors that correlate with overall survival (OS) after MBM diagnosis. However, molecular and immune features associated with OS are poorly understood. An …
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Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… analysis of clinical samples that melanoma brain metastases (MBMs) have higher expression of oxidative phosphorylation (OXPHOS) genes (including <em>PPARGC1A</em> or <em>PGC1α</em>) than patient-matched extracranial metastases (ECMs). <strong>Thus, the central hypothesis of this dissertation …
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Simvastatin Does Not Sensitize Ibc3 Her2+ Inflammatory Breast Cancer Brain Metastases to Whole Brain Irradiation In An Immunocompromised Mouse Model
… radiosensitizes IBC cells in vitro [23], and brain metastases have strong expression of cholesterol-regulation genes compared to lung metastases <em>in vivo</em> [unpublished]. Delaying whole-brain irradiation (WBI) beyond 21 days is insufficient to reduce the incidence of brain metastases …
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"Interactions and invasiveness of melanomatous human tumor cells within the blood brain barrier endothelium".
Brain metastases occur in about 25% of patients who die of cancer.One of the most common sources of brain metastases in adults is cutaneous melanoma.The malignant potential of melanomatous cell and its adhesion to the cerebral endothelium plays a key role in this process.The aim of this study was …
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Prophylactic Cranial Irradiation Reduces The Incidence of Brain Metastasis In A Mouse Model of Metastatic Breast Cancer
… irradiation (PCI) is a preventative whole-brain irradiation technique used to reduce the incidence of brain metastasis and improve overall survival in select patients with small cell lung cancer and acute lymphoblastic leukemia. A population of breast cancer patients – stage IV, HER2+ or …
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The Role of Type I Insulin-Like Growth Factor Receptor Signaling In Breast Cancer Brain Metastasis
<p>Brain metastasis is a common cause of mortality in cancer patients. Approximately 20-30% of breast cancer patients acquire brain metastasis, yet potential therapeutic targets remain largely unknown. The type I insulin-like growth factor receptor (IGF- IR) is known to play a role in the …
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Modeling Recurrent Metastatic Events
… mortality of cancer patients, for example with metastases to the brain being highly lethal, but the underlying mechanisms are poorly understood. Here, we aim to characterize the genetic landscape of metastatic drivers to specific organ sites using large-scale tumor sequencing and medical record …
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Identification of epigenetically dysregulated genes in tumours that metastasise to the brain
Tumour metastasis to the brain is a common and deadly development in certain cancers; 18-30% of breast tumours metastasise to the brain. The contribution that gene silencing through epigenetic mechanisms plays in metastasis to the brain is not well understood. To identify epigenetic drivers of …
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Bio-Inspired and Nanotechnology-Enabled Drug Delivery for Diabetes and Brain Cancer
… imaging agents and drugs across the blood-brain barrier by mimicking low-density lipoprotein uptake in the brain. We developed this system based on a polysorbate 80-containing terpolymer for improving chemotherapy of metastatic breast cancer disease in the central nervous system. Two …
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In Vivo Kinome Screen Reveals Non-Canonical Cdk-Driven Metabolic Adaptation In Brain Metastasis
<p>Brain metastasis, which frequently arises from breast cancer, lung cancer, melanoma, and colorectal cancer, remains a severely unmet medical need and its incidence continues to rise while treatment options remain palliative. To better understand the biology underlying its aggressive, incurable …
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RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO
… 12 million long-term cancer survivors, brain metastases are a significant risk. Fractionated partial or whole-brain irradiation (fWBI) is often required to treat both primary and metastatic brain cancer. Radiation-induced normal tissue injury, including progressive cognitive impairment, …
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OPTIMIZED APPROACHES FOR LIQUID BIOPSY IN GLIOBLASTOMA PATIENTS
… Glioblastoma (GBM) remains the deadliest primary brain tumour, with a 5-year survival < 4 % despite maximal multimodal therapy. Its diffuse infiltration, marked spatial-temporal heterogeneity, and the shielding effect of the blood–brain barrier (BBB) limit the accuracy of tissue biopsy and …
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Physical and biological characterisation of clinically relevant combined MRI-radiation exposures with conventional and nanoparticle contrast agents
… MRI scanners before being compared with patient brain scans to determine clinical relevance of concentrations used in vitro, and combinations of clinical and radiomics features were evaluated using Kaplan-Meier Curves and Hazard Ratios to design a predictive model of overall survival for brain …
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Targeting tGLI1-positive Breast Cancer with Ketoconazole
… second most common cancer to metastasize to the brain. Current standard of care for breast cancer brain metastases (BCBM) involves surgical resection of individual lesions and whole brain radiotherapy (WBRT) for multiple lesions, however, effective FDA-approved drugs for patients with …
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
<p>Breast cancer brain metastases have remained one of the most intense challenges for precision cancer therapeutics, but current treatment options are limited and not curative. Recently, our lab reported that adoptive <em>PTEN</em> downregulation in metastatic breast tumor cells activates …
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An investigation into the mechanisms of angiogenesis and breast cancer metastasis
… primary breast tumours that metastasise to the brain occur. Brain tumours are heterogenous malignancies with a low survival rate. Tumours often development therapy resistance by secreting different pro-angiogenic growth factors that allow them to overcome the effect of anti-angiogenic drugs. …
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Improving Segmentation Pipelines for Medical Imaging using Deep Learning
… the treatment response assessment of metastatic brain tumor patients on MRI. Due to the large number of metastases a patient can have, standard radiographic analyses track only a select few target lesions through the course of therapy in order to assess the efficacy of a treatment. With this …
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The molecular landscape of cutaneous melanoma and its clinical implications
… a particular propensity to metastasise to the brain and the mechanisms underlying this devastating complication remain incompletely understood. Melanoma risk stratification has traditionally relied on the examination of clinical and pathological features, however it has become clear that …
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The role of Inhibitors of Differentiation proteins ID1 and ID3 in breast cancer metastasis
… of breast cancer. ID1 expression is enriched in brain metastases compared to patient matched primary breast cancers. Silencing of Id1/3 reduces primary tumour growth and significantly impairs spontaneous lung metastasis. These data strongly suggest Id1/3 as central controllers of the metastatic …
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