Global ETD Search
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Showing 1 to 20 of 24 for “"brain ischemia"”.
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Ribonomic Control During Global Brain Ischemia And Reperfusion
… <p>RIBONOMIC CONTROL DURING GLOBAL BRAIN ISCHEMIA AND REPERFUSION</p> <p>by HAIHUI WANG</p> <p>August 2014</p> <p>Advisor: Donald J. DeGracia, Ph.D.</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>The study presented here used "omic" technology to look at the …
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Mechanisms of translation arrest following focal brain ischemia
… OF TRANSLATION ARREST FOLLOWING FOCAL BRAIN</p> <p>ISCHEMIA</p> <p>by</p> <p>MONIQUE K. LEWIS</p> <p>August 2011</p> <p>Advisor: Dr. Donald DeGracia</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>The loss of blood flow to the brain is termed ischemia and the …
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Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury
… in most patients revived after cardiac arrest is ischemia and reperfusion (I/R) injury in the brain. Survival after brain I/R injury depends on the expression of new stress response proteins such as heat shock protein 70 (HSP70). Little is known about why recovering neurons are able to express new …
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Mechanisms of persistent translation arrest following global brain ischemia and reperfusion
… PERSISTENT TRANSLATION ARREST FOLLOWING GLOBAL BRAIN ISCHEMIA and REPERFUSION</p> <p>by</p> <p>JILL T. JAMISON</p> <p>December 2011</p> <p>Advisor: Donald J. DeGracia, Ph.D.</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>The information presented here studies the mechanisms …
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Einflüsse einer inkompletten cerebralen Hemisphären-Ischämie und Reperfusion auf das Verhalten, die kognitiven Fähigkeiten und die Mikromorphologie des zentralen Nervensystems bei Sevofluran anästhesierten Ratten
… hippocampal injury produced by incomplete brain ischemia and reperfusion of sevoflurane anesthetized rats was investigated by using the modified hole-board-test (OHL et al. 1998).
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Non-canonical Activation of CREB/crh-1 Mediates Neuroprotection in a <i>Caenorhabditis elegans</i> Model of Excitotoxic Necrosis
… which is a major cause of neurodegeneration in brain ischemia, can also activate neuroprotective pathways. A frequently suggested neuroprotective cascade involves the activation of the transcription factor CREB by its phosphorylation, but on its own this mode of CREB activation is promiscuous. …
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NEUROPROTECTIVE THERAPIES CENTRED ON POST-TRANSLATIONAL MODIFICATIONS BY SUMOYLATION
… modulate the pathogenesis of evolving ischemic brain injury. The paucity of therapeutic options stands in stark contrast to the intensity of research efforts/number of clinical trials that have been performed to date. Further, there are, as of yet, no effective treatments (neurorehabilitation …
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Preclinical Evaluation Of Infrared Light Therapy In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy
… studies using a rat model of adult global brain ischemia, IRL treatment attenuated cerebral injury resulting from hypoxia-ischemia in the neonatal rat. Thus, and perhaps most importantly, this work contributes to the development of a potential novel therapeutic approach in the management of …
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fMRI assessment of ischemic stroke in humans
Cerebral ischemia, or brain ischemia is a kind of stroke where the blood flow is insufficient to the metabolic demand of brain. The lack of oxygen supply will directly lead to the death of brain tissue. There are two major injury regions: the infarct and penumbra. Mostly, since the infarct regions …
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The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier
… FoxO3a-mediated degradation of claudin-5 during ischemia/hypoxia using the mouse middle cerebral artery occlusion (MCAO) model and hypoxia model. The possible underlying mechanisms are also investigated, especially those linked to the oxidative stresses. Onion extract (OE) and its major …
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A Study of Measuring Intracranial Pressure Using a Non-Invasive Piezoelectric Sensor
The brain, like many parts of the human body, can experience swelling, also known as cerebral edema. Cerebral edema may occur because of an injury, health related issues, tumors, or even high altitudes[1]. When cerebral edema occurs, a rise in intracranial pressure (ICP) becomes prevalent and may …
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Novel roles of striatal enriched protein phosphatase (STEP) in neuronal intrinsic properties and homeostatic synaptic plasticity
STriatal Enrich Protein Phosphatase (STEP) is a brain specific protein tyrosine phosphatase, which is only expressed in the central nervous system (CNS). STEP has two major isoforms, including STEP46 and STEP61 and membrane-bound STEP61 is implicated in multiple neurologic disorders. For example, …
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Modulation as an Acidosis-Evoked Current by A1 Adenosine Receptors in the CA1 Region of the Mouse Hippocampus
… consequences of reduced blood flow to the brain. Acidosis exacerbates ischemic brain injury by activating non-selective cation currents that induce neuronal damage in a calcium-dependent manner, independent of glutamate receptor activation. Adenosine is released during periods of metabolic …
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Gender-linked brain injury as exemplified in rat models of hypoxia and ischemia
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Mathematical Model for Hemodynamic and Intracranial Windkessel Mechanism
… condition such as hydrocephalus and traumatic brain injury (TBI) is still subtle. Especially, the cause of hydrocephalus which is known as the common birth defect is not well defined. Traditionally, hydrocephalus was described as imbalance between production and absorption process of …
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Targeting Cholinergic Neuromodulation in Stroke Recovery
… controlling functional plasticity in the injured brain could each be key to producing better recovery in stroke patients. To work toward better functional assessment of stroke deficit and recovery in the mouse model, I developed an automated reach task in the mouse model that produces a longer …
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Long-Term T Cell Responses in the Ischemic Brain
… worldwide. Following ischemic injury, blood-brain barrier integrity is disrupted and multiple inflammatory cascades are initiated both in the central nervous system and in the peripheral immune system. These early inflammatory responses result in the recruitment of systemic immune cells into …
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Long-Term T Cell Responses in the Ischemic Brain
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Comparison of transplantation modality of human mesenchymal stem cells expressing neurogenin1 in rat middle cerebral artery occlusion model: intra-arterial vs. intra-cerebral
… and the serial changes of infarct volume in brain magnetic resonance image (MRI). MRI analysis with the SPIO-labeled cells indicated more even distribution in the animals with IA-MSCs/Ngn1 than the one with IC-MSCs/Ngn1. The animals with IA-MSCs/Ngn1 showed significantly higher recovery in …
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