Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"brain inflammation"”.
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Brain Inflammation Regulated by PINK1
… In this study, I analyzed the roles of PINK1 in brain inflammation using slice cultures prepared from PINK1 knockout (KO) and wild type (WT) mice since slicing mimics injury. For up to 24 h after slicing, mRNA expression levels of pro-inflammatory cytokines (TNF-a, IL-1b, and IL-6) measured at 6 …
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Targeting brain inflammation with bioconjugated nanoparticles
Brain inflammation has been implicated with the pathogenesis of neurodegenerative diseases. Activated microglia and endothelial cells induce production of reactive oxygen species (ROS) and overexpress pro-inflammatory mediators that perpetuate tissue damage. Current treatments are not effective …
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Changes in Balance with Brain Inflammation: Sensitivity in Dual Motor Mechanisms
… to potential long-term consequences of traumatic brain injuries. Evaluating balance alterations is crucial for understanding post-injury motor control strategies. This study introduces a novel approach to understanding center of pressure (COP) dynamics during quiet stance tasks for assessing …
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Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation
… suggest that PIP5KIα may act as a regulator of brain inflammation by modulating NF-κB signaling.
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Modulation of Brain Inflammation Induced by Interaction between Astrocytes, Neutrophils and Monocytes
… TABLES v ABBREVIATIONS vi I. Introduction 1 A. Brain inflammation 1 B. Microglia and astrocytes as main regulators of brain inflammation 1 1. Microglia 1 2. Astrocytes 3 C. Leukocytes: immune cells to infiltrate the injured brain 3 D. Regulation of brain inflammation 5 1. Stimulators of …
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The Role of Microglia in the Effects of Steroid Hormones on Brain Inflammation
… effects of steroid hormones in the brain, with particular emphasis on the neuroprotective hormone 17β-estradiol (E2), and the anti-inflammatory steroid, corticosterone. To address this problem, microglia culture models were established using a microglia cell line and primary cultures …
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Studies on the Cellular Responses and Roles of Microglia, Astrocytes, and Blood-Derived Inflammatory cells in Injured Rat Brain
Brain inflammation is accompanied by brain injury. For several decades, brain inflammation has been considered toxic to the brain. However, recent studies also suggest beneficial roles of inflammation in injured brain. In this study, I analyzed patterns and roles of brain inflammation in injured …
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The effect of omega-3 fatty acid supplementation and transcranial direct current stimulation on plasma cytokines
… cytokines as an assessment of potential neuro inflammation. Migraine is a common disabling brain disorder influencing physical, mental, and social dimensions of quality of life. Typically, brain inflammation and migraine treatment are through pharmacologic means that often do not have …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
"Cholesterols are enriched in the brain and can be oxidized to oxysterols by spontaneous or enzyme-mediated processes. Oxysterols are transport forms of cholesterols across cell membranes and the blood-brain barrier. Here, to elucidate the roles of oxysterols in brain inflammation, I treated …
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Effect of IBC isolated from Psoralea corylifolia on expression of adhesion molecule-1 in cerebrovascular endothelial cells
Brain inflammation has been implicated in various cerebral diseases. Leukocyte-infiltration into brain parenchyma is critically associated with in the development brain inflammation. Therefore, control of leukocyte infiltration is a very important therapeutic target for the treatment of …
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The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study
… investigated the role of systemic markers of inflammation and oxidative stress, inflammatory changes in the brain on magnetic resonance spectroscopy (MRS) and the role of the APOE E4 allele in HIV-associated dementia (HAD) in a South African population. We hypothesized that cognitive …
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Intermittent fasting as a therapeutic strategy for alzheimer’s disease: behavioral and molecular evidence
… non-pharmacological intervention to improve brain health and mitigate neurodegenerative disease progression. Alzheimer’s disease (AD) is characterized by impaired metabolic functions that disrupt neuronal function and contribute to cognitive decline in aging populations. This dissertation …
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Studies on the Mechanism of Polyamine-and Prothrombin kringle-2-induced Degeneration of Neuron and Microglia
… Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD). In the central nervous system, microglia, the resident innate immune cells play major role in inflammatory process. Microglia may …
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Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells
… functions in sterile inflammatory diseases. Brain inflammation is a process of host defense against infection or injury. Microglial cells and astrocytes, major immune effector cells, have a pivotal role in the brain inflammation. Thus, to understanding how microglia and astrocytes are …
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CYTOKINE CONTROL OF GLIOMA ADHESION AND MIGRATION
… than 12 months because dissemination into the brain parenchyma limits the long-term effectiveness of surgical resection, and because GBM cells are resistant to radiation and chemotherapy. This sad dismal prognosis for patients with GBM emphasizes the need for greater understand of the …
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DJ-1, a Parkinson’s Disease-associated Gene, Prevent Excessive Glial Inflammatory Responses through Interaction with SHP-1
… on IFN-g. Similar results were obtained in brain slice cultures, where IFN-g induced much stronger STAT1 phosphorylation and inflammatory responses in KO slices than in WT slices. Moreover, IFN-g treatment induced neuronal damage in KO slices. Collectively, these findings suggest that DJ-1 …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
It is well known that excessive brain inflammation cause both acute and chronic neurodegeneration. Our previous study demonstrated the neuroprotective effects of IL-10 in LPS-injected rat cerebral cortex, which was mediated by inhibition of NADPH oxidase activation and pro-inflammatory mediators …
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Nipah: The history, and future, of one of the world’s most lethal viruses
… fell ill with fevers and encephalitis, or brain inflammation. Nipah has caused smaller outbreaks in nearby Bangladesh nearly every year since then. The Malaysian farmers appeared to have been infected directly from their pigs, rather than from each other. For a time, there was no clear …
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role of pentazocine in an in vitro model of hypoxia/reoxygenation
… the balance between toxic and protective brain innate immunity. Sigma-1 receptor is expressed in both neurons and glia is a unique class of intracellular proteins and is involved in neurodegeneration. Our aim was to evaluate the biological effects of sigma-1 selective ligands, and …
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