Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"brain gene expression"”.
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Nutritional status influences behavior, physiology, and brain gene expression in primitively eusocial Polistes metricus paper wasps
… different levels: behavior, physiology, and brain gene expression. In order to understand the effects of nutrition, I manipulated the amount of nutrients received by Polistes metricus wasp colonies in the laboratory. The starved group received less prey and sugar during a limited time frame …
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Genomic studies of social evolution in bees
… genomics approach to identify hundreds of genes that are rapidly evolving in eusocial bees. Additionally, I highlight biological processes, such as carbohydrate metabolism, which may have been important targets of natural selection during the evolution of eusociality in these bee lineages. …
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Molecular Underpinnings of Human Brain Evolution and Cognition at Cellular Resolution
… for publication) titled "Differences in brain gene expression between humans and primates", which has been accepted for publication as a chapter in the book titled "The evolutionary roots of human brain diseases". This chapter is an edited version of the author's own original writing with …
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Prenatal dexamethasone exposure: glucocrticoid programming of the brain
… overexposure effects on the functioning of the brain and investigated possible molecular mechanisms underlying the programmed effects. By using a rat model of prenatal dexamethasone (100μg/kg per day) administered to pregnant dams during the last week of gestation, I found that prenatal …
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Functional genomics studies of human brain development and implications for autism spectrum disorder
Human neurodevelopment requires the coordinated expression of thousands of genes, exquisitely regulated in both spatial and temporal dimensions, to achieve the proper specialization and inter-connectivity of brain regions. Consequently, the dysregulation of complex gene networks in the developing …
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Neurogenomic architecture of honey bee social behavior
… events. How social information is encoded in the brain and informs social decision-making, and how this process is shaped by the environment, are fundamental questions in neuroscience. In this dissertation, I address these questions by deploying systems-level approaches to understanding layers of …
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Mechanisms involved in eusocial evolution in bees
… Chapters 2 and 3 are aimed at identifying genetic changes associated with social evolution in insects. In Chapter 2, I review and synthesize current developments in molecular evolutionary analyses of social evolution in bees, wasps, ants and termites. In Chapter 3, I use comparative …
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Investigation into Toxoplasma gondii infection in relation to expression of neurodegenerative disease markers in natural mice populations
… whether detection of T. gondii in cadaveric brain tissue of patients, who had been previously diagnosed with Alzheimer’s Disease (AD), could be used to investigate the role of this parasite in AD. Secondly to investigate T. gondii infection in naturally infected wood mice (Apodemus …
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Molecular bases of scouting behavior in honey bees
… and is therefore associated with differences in brain dopaminergic, octopaminergic and glutamatergic systems. I found significant brain down- regulation of the D1-type dopamine receptor genes and upregulation of the octopamine receptor genes in scouts compared to non-scouts. Microarray analysis …
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Immunological and behavioral consequences of high-fat diet feeding in mice
… Co-morbidities accompanying this disease include brain-based disorders that impact cognition and mood. Anhedonia is a biobehavior associated with depression that manifests in mice as a loss of interest in consuming a highly palatable sucrose or saccharin solution. Here we show that obese mice fed …
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LARGE-SCALE DATA ANALYSIS OF GENE EXPRESSION MAPS OBTAINED BY VOXELATION
Gene expression signatures in the mammalian brain hold the key to understanding neural development and neurological diseases, and gene expression profiles have been widely used in functional genomic studies. However, not much work in traditional gene expression profiling takes into account the …
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Nutrition, Hormones, Transcriptional Regulatory Networks and Division of Labor in Honey Bee Colonies
… involve coordinated and long-lasting changes in gene expression, brain circuitry, brain chemistry, and endocrine signaling [2]. My doctoral research has focused on understanding the molecular basis for nutritionally- and hormonally-mediated plasticity in the behavior and physiology of worker …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
… encephalopathy is an important cause of brain injury in the newborn due to a systematic asphyxia. Our study aims to test the hypothesis that maternal hypoxia affect the organogenesis of the kidney by affecting the kidney structure and focusing on the roles of AT1R and AT2R, while the …
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Androgen Regulation of Gene Expression Associated with Cell Growth and Neural Plasticity: Studies in Songbird Brain and the S115 Cell Line
… order to characterize androgens' effects on the brain and behavior I identified the canary cDNA coding for the nuclear receptor for androgen. The sequence is very conserved over functional domains, but shows some divergence from the only other sequences known, those for rodents and man. The AR …