Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"brain endothelium"”.
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Cyclooxygenase-2 is Associated with Cadmium-induced ICAM-1 Expression in Brain Endothelial Cell
… showed that Cd accumulates out-side of blood brain barrier (BBB) and induces the leakage of BBB, suggesting brain endothelium as a putative target. Recently, we have reported that Cd stimulates ICAM-1 expression via NF-kB activation in bEnd.3 cerebrovascular endothelial cells. And also, we …
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Molecular and Mechanical Heterogeneity in Adult and Paediatric High-Grade Glioma
… interactions of tumour cells with the brain endothelium directing proliferation, invasion, and presence of neural stem cell markers. Finally, in each of these settings, we use targeted pharmacological interference to determine biological mechanism and potential therapeutic targets. This …
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Gold Nanoparticles as a Delivery System of Oligonucleotides into the Brain
The treatment of brain disease is challenging due to the blood-brain barrier, a physiological structure that prevents the majority of potential therapeutic agents from entering the brain. One approach to overcome this problem is the use of nanoparticles as a delivery system. Several types of …
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The Role of Astrocyte-Derived Factors in the Regulation of Multidrug Resistance at the Developing Blood-Brain Barrier
… (P-gp; encoded by Abcb1) at the blood-brain barrier (BBB) plays an important role in regulating the movement of exogenous and endogenous substrates into the developing brain. P-gp levels in brain endothelial cells (BECs), which form the capillaries of the BBB, increase dramatically in …
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Η μελέτη της επίδρασης του οξειδωτικού στρες στην οκλουδίνη, βασικού δομικού μορίου των στενών δεσμών (tight junctions) του αιματοεγκεφαλικού φραγμού σε επίμυες. Μελέτη της πιθανής προφυλακτικής επίδρασης αντιοξειδωτικών παραγόντων
Ο αιματο-εγκεφαλικός φραγμός (ΑΕΦ) παίζει έναν καθοριστικό ρόλο στην ομοιόσταση του Κεντρικού Νευρικού Συστήματος. Οι στενοσύνδεσμοι (TJ) των ενδοθηλιακών κυττάρων των εγκεφαλικών τριχοειδών συνεισφέρουν σημαντικά στη λειτουργία του ΑΕΦ περιορίζοντας την παρακυτταρική διάχυση. Η οκλουδίνη, μια …