Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"brain endothelial cells"”.
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The effects of ethanol and aspalathus linearis on immortalized mouse brain endothelial cells (bEnd5)
The blood brain barrier (BBB) is a signaling interface between the blood and the central nervous system (CNS), which prohibits the entry of harmful blood-borne substances into the brain micro-environment, thus maintaining brain homeostasis. The crucial role of the BBB is protecting the CNS, which …
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Role of Trp Channels In Mediating The Calcium Signaling Response of Brain Endothelial Cells to Mechanical Stretch
<p>Traumatic brain injury (TBI) often results in disruption of the blood brain barrier (BBB), which is an integral component to maintaining the central nervous system homeostasis. Recently cytosolic calcium levels ([Ca<sup>2+</sup>]i), observed to elevate following TBI, have been shown to influence …
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Brain Endothelial Cells Orchestrate an Anti-Encephalitic State in the Central Nervous System in Response to Peripheral Viral Infection
<p>Vertebrates have a unique organ called the brain, which along with the spinal cord forms the central nervous system (CNS). This organ takes in sensory data from the environment for analysis and coordinates appropriate responses, enabling individuals to quickly react to highly complex problems …
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
… patients showing metastatic lesions to the brain and a 30% five-year survival rate post-diagnosis, secondary tumors to the brain are a leading cause of cancer-related deaths. Understanding the mechanisms of tumor cell extravasation at the brain is therefore crucial to the development of …
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Profiling the neurovascular cell interactions in alcohol exposure and HIV-1 infection
… immunodeficiency syndrome or HIV/AIDS in the brain, known as the NeuroAIDS. The mechanisms of this accelerated progression are still poorly understood. The purpose of my thesis is to review the parameters contributing to the co-morbid effects of alcohol in the progression of NeuroAIDS. The …
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U0126, MEK1/2 inhibitor, Induces Adhesion Molecules Expression in Human Blood Cells
… in monocyte transmigration and adherence to endothelial cells, causing inflammatory responses in vascular lesion. MAPKinase pathway has been known to be activated in inflammatory responses. In this study, we investigated the expression of adhesion molecule by MEK1/2 inhibotors such as U0126 …
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The Development of a Drug Delivery System Using Brain Endothelial Non-Antibody Binding Domains as Transport Carriers
The highly specialised brain capillary endothelial cells (BCEC) that constitute the blood brain barrier (BBB) exhibit high resilience to the penetration of xenobiotic and biologic therapeutics, making drug delivery to the central nervous system (CNS) a challenging feat. Endogenous BCEC receptors …
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Investigating peripheral inflammation induced neuroinflammation in the absence of blood-brain barrier breakdown in relation to Alzheimer’s disease
… by which peripheral signals influence the brain, particularly when the blood-brain barrier (BBB) remains intact, remain poorly understood. To investigate how peripheral inflammatory signals can propagate to the neurovascular unit (NVU), an in vitro BBB model was developed using brain …
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Effect of IBC isolated from Psoralea corylifolia on expression of adhesion molecule-1 in cerebrovascular endothelial cells
Brain inflammation has been implicated in various cerebral diseases. Leukocyte-infiltration into brain parenchyma is critically associated with in the development brain inflammation. Therefore, control of leukocyte infiltration is a very important therapeutic target for the treatment of …
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Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells
… prostanoid and play an important role in brain disease through binding to four G protein-coupled receptor (EP1-4). However, there have been contradictory reports on its actions in inflammation processes. For instance, PGE2 inhibits or stimulates ICAM-1 expression depending on the cell type …
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The Role of Astrocyte-Derived Factors in the Regulation of Multidrug Resistance at the Developing Blood-Brain Barrier
… (P-gp; encoded by Abcb1) at the blood-brain barrier (BBB) plays an important role in regulating the movement of exogenous and endogenous substrates into the developing brain. P-gp levels in brain endothelial cells (BECs), which form the capillaries of the BBB, increase dramatically in …
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Investigating the inhibitory effects of secreted proteins on macrophage in glioblastoma
… the most common and aggressive form of malignant brain tumours, especially in the adults. The complex tumour microenvironment of glioblastoma contributes to immune suppression and inhibition of T cell activity through secreted immuno-suppressive proteins and cytokines, dysfunction of immune cells …
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Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier
… strategies to regulate drug disposition into the brain. Immortalized rat brain endothelial cells (RBE4 cells) have been used in this study as an in vitro model of the BBB. The present study has shown that the RBE4 cells are a suitable model of the BBB for transporter studies. These cells do …
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Mechanisms of Hypoxia-Induced Neurovascular Remodeling in PlGF Knockout Mice
… and low capacity for energy storage of the brain, neurons are vitally reliant on a constant oxygen supply. Under chronic mild hypoxic conditions (10% oxygen), angiogenesis is induced in the brain in an attempt to restore tissue oxygen tension to normal levels. In brain hypoxia, vascular …
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Molecular Profiling and Mechanisms of Cerebrovascular Function in Health and Neurodegeneration
… inefficient delivery strategies to target the brain. The cerebrovasculature is essential for proper brain function as it tightly regulates blood flow and supplies the necessary nutrients. Furthermore, the presence of a bloodbrain barrier (BBB) provides protection to vulnerable neurons but poses …
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Molecular Mechanisms Involved in Escherichia coli K1 and Haemophilus influenzae Type a Blood-Brain Barrier Impairment
Blood Brain Barrier (BBB) is a protective barrier against possible neurotoxic molecules, such as proteins or endogenous metabolites, xenobiotics derived from the environment or ingested with the food. At the same time, BBB selectively allows the cross of ions and nutrients from blood into the CNS …
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Targeting brain inflammation with bioconjugated nanoparticles
Brain inflammation has been implicated with the pathogenesis of neurodegenerative diseases. Activated microglia and endothelial cells induce production of reactive oxygen species (ROS) and overexpress pro-inflammatory mediators that perpetuate tissue damage. Current treatments are not effective …
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Neurotoxic effects of malathion and lead acetate on the blood-brain barrier: Disruptive effects caused by different mechanisms examined with an in vitro blood-brain barrier system
… on the nervous system, but also on the blood-brain barrier (BBB). The BBB consists of specialized endothelial cells that form the vasculature of the brain; it regulates passage of nutrients, while preventing potentially damaging substances from entering the brain. The main feature of the BBB …
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Modeling the Heterogeneous Brain Tumor Microenvironment to Analyze Mechanisms of Vascular Development and Chemoresistance
… to generate in vitro models of the heterogeneous brain tumor microenvironment, with a focus on vascular dynamics, to probe the impact of microenvironmental cues on tumor progression and to integrate the tumor models with highly sensitive analytical tools to characterize the epigenome of discrete …
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Gold Nanoparticles as a Delivery System of Oligonucleotides into the Brain
The treatment of brain disease is challenging due to the blood-brain barrier, a physiological structure that prevents the majority of potential therapeutic agents from entering the brain. One approach to overcome this problem is the use of nanoparticles as a delivery system. Several types of …
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