Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"brain diseases"”.
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Molecular Underpinnings of Human Brain Evolution and Cognition at Cellular Resolution
… for publication) titled "Differences in brain gene expression between humans and primates", which has been accepted for publication as a chapter in the book titled "The evolutionary roots of human brain diseases". This chapter is an edited version of the author's own original writing with …
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Trans-skull Ultrasound for Imaging and Therapy
… novel modality for the treatment and imaging of brain diseases. When enhanced by circulating microbubble agents, which scatter sound and vibrate in response to the incident ultrasound, it can enable a range of new therapeutic interventions and open new possibilities for imaging. Despite these …
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Strategies for developing ultrathin, high-density, actively multiplexed neural mapping device
… rise in the interest of diagnosing and treating brain diseases it is critical that electrodes involving brain/machine interfaces have minimal effect on the brain while ensuring conformal coverage and good signal quality. A two-stage attempt is described in this thesis, where technological …
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Quantitative analysis of cerebral white matter anatomy from diffusion MRI
… the changes in the diffusion measures and brain diseases, development, and aging. The proposed quantitative analysis is performed on a group of fiber trajectories extracted from diffusion MRI by a process called tractography. To enable the quantitative analysis we first need to cluster …
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Methods to measure and relate the viscoelastic properties of brain tissue
Measurement of brain tissue elastic and viscoelastic properties is of interest for modeling traumatic brain injury, understanding and creating new biomarkers for brain diseases, improving neurosurgery procedures and development of tissue surrogate materials for evaluating protective strategies …
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Towards a complete human cell atlas: a single-nucleus RNA sequencing study of the paediatric and adult human brain
Postnatal human brain maturation from birth to early adulthood represents a period of susceptibility for neuropsychiatric risk. While temporal gene expression dynamics over this period have been studied extensively, there are no studies exploring the paediatric brain at single cell resolution. To …
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Development of Quantitative Tools for the Characterization and Analysis of the Blood Brain Barrier in Normal and MPS IIIB Mice
<p>The Blood Brain Barrier (BBB) functions to control homeostasis within the central nervous system (CNS) via strict control over the passage of molecules into and out of the brain. The goal of this barrier is to protect the CNS from harmful external factors while allowing entry of essential …
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Optimization-Based Methods for Reconstruction and Structural Quantification of Neurons and Glia from Microscopic Images
… central nervous system and drug development for brain diseases. It requires the accurate reconstruction of the interesting structures and the design of quantitative metrics to describe the morphology. Structural quantification of myelin sheaths from in vivo light microscopy imaging gives insights …
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Arterial Spin-labelled MRI Analyses to Advance Adolescent Bipolar Disorder Research and Clinical Applications
Cerebral blood flow (CBF) is foundational to brain function in health and disease. Through three distinct analyses, the aim of this thesis is to extend current understanding of CBF in adolescent bipolar disorder and to enable future understanding of CBF in other brain diseases. CBF measurement can …
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Magnetic Resonance Imaging of Cerebral Venous Oxygenation
… oxygenation (Yᵥ) is an important biomarker for brain diseases. My dissertation consisted of two studies. The first study aims to investigate the regional Yᵥ in hypertension. Hypertension is known to cause cerebral hypoperfusion and cortical atrophy but its impact on Yᵥ is not yet clear. A 2D …
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Accelerating development of treatments for trigeminal neuralgia using intranasal delivery and a novel behavioral screening device for rats.
… poor targeting to the trigeminal, orofacial and brain structures involved. Intranasal administration targets these structures while minimizing systemic exposure and side effects. Lidocaine was intranasally administered to rats, and the trigeminal nerve and trigeminally-innervated structures …
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Topic Modeling for Inferring Brain States from Electroencephalography (EEG) Signals
<p>Inferring brain states from EEG signals allows for the management of sleep disorders and brain diseases by providing an insight into the electrophysiological state of the brain. We explore the use of topic modeling – which are popular text processing algorithms – to infer brain states from EEG …
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Developing Tools to Physically Magnify Biological Substrates for Clinical Applications
… which interact over nanoscale distances. Diseases, especially in their earliest stages, are associated with subtle changes in the presence and organization of biomolecules in cells and tissues. Expansion microscopy (ExM), a method of physical specimen expansion that preserves …
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Fast finite element methods for focused ultrasound applications
… especially for the treatment of cancers and brain diseases. Effective patient-specific treatment planning can be supported by accurate simulations. However, this poses a challenge from a computational standpoint since the ratio of the domain size to the wavelength is typically large, …
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Topology matters: characteristics of functional brain networks in healthy subjects and patients with Epilepsy, Diabetes, or Amyotrophic Lateral Sclerosis during a resting-state paradigm.
The brain can be seen as a complex structural and functional network. Cognitive functioning strongly depends on the organization of functional brain networks. EEG/MEG resting-‐state functional connectivity and functional brain networks studies attempt to characterize normal brain organization as …
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Enteric and hepatic glia-like cell reactivation after astrocyte-directed twinkle helicase loss
Mitochondrial brain diseases, such as Alpers-Huttenlocher syndrome and mitochondrial recessive ataxia syndrome, are complex and severe metabolic diseases with variety of symptoms that lack any treatment. Multiple different mutations in the proteins taking part in the mitochondrial DNA (mtDNA) …
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Transport of Antibodies and Nanoparticles across An in vitro Blood-Brain Barrier
"The blood-brain barrier (BBB) is a dynamic interface between the blood circulation and the central nervous system (CNS). While it serves as a selective barrier to water and solutes to prevent the blood-borne toxins from entering into the brain tissue, it hinders the drug delivery to the CNS for …
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Modulatory effects of GluN1 autoantibodies on brain function
… circulatory system are able to cross the blood-brain-barrier (BBB) and enter the central nervous system (CNS) to modulate brain function, as supported by findings in vaccination strategies for Alzheimer’s disease (AD) in mouse models and autoimmune disease models. Our laboratory has previously …
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Development and utilization of Luminex biomarker assays for diagnosis and monitoring of neurodegenerative disease
… is the accumulation of misfolded proteins in the brain. Neurodegenerative disorders associated with protein misfolding include Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), fronto-temporal lobar degeneration (FTLD), motor neuron disease (MND), Huntington’s …
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