Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"brain disease"”.
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Depression is a brain disease: An examination of the impact of biological explanations of mental illness
… either saw the message “depression is a brain disease” or a control message. Stigma levels were compared from before and after and across conditions, and affect was compared across conditions. Changes were not observed in stigma measures as a result of the experimental manipulation. The …
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Depression is a brain disease: An examination of the impact of biological explanations of mental illness
… either saw the message “depression is a brain disease” or a control message. Stigma levels were compared from before and after and across conditions, and affect was compared across conditions. Changes were not observed in stigma measures as a result of the experimental manipulation. The …
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Carbon and Deuterium MRI studies of human brain metabolism
Metabolic changes to the brain can be due to brain disease causing impaired functioning. Imaging of the metabolic processes is an emerging area of research that can allow for greater understanding of the brain disease whilst offering clinical potential for improved diagnosis. Hyperpolarized (HP) …
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Prior information for brain parcellation
To better understand brain disease, many neuroscientists study anatomical differences between normal and diseased subjects. Frequently, they analyze medical images to locate brain structures influenced by disease. Many of these structures have weakly visible boundaries so that standard image …
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I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules
… modulation is examined. Its signaling, role in brain disease, and reported agonists and antagonists are reviewed. In addition, our attempts at establishing an assay to assess TrkB activation, as well as our results using the reported agonists and an antagonist in several model cell lines, are …
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Substance use disorder, shame, and self-forgiveness: A latent profile analysis
Substance use disorder (SUD) is a chronic brain disease characterized in part by one’s inability to emotionally self-regulate. Whereas multiple forgiveness interventions have been implemented to provide alternative strategies for emotional regulation, self-forgiveness interventions are believed to …
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Electrophysiological characterization of a mouse deficient for oligophrenin1: a mouse model of X-linked mental retardation
Mental retardation is the most common brain disease. One of the first genes identified in X-linked mental retardation (XLMR) was the OPHN-1 gene. Mutation of this gene has been described in patients with moderate to severe cognitive impairments. MR is characterized by reduced cognitive function …
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IDENTIFYING THE GENETIC MECHANISMS IN SEIZURE THRESHOLD REGULATION
<p>Epilepsy is a brain disease defined by having recurrent and spontaneous seizures. The susceptibility to seizure is determined by seizure threshold, which describes the balance between excitatory and inhibitory neurotransmission in the brain. Epileptogenesis, the transition from normal brain to …
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Role And Impact Of The Gut Microbiota In A Drosophila Model For Parkinsonism
… relationship between microbes in the gut and the brain, including an impact on brain disease development, severity, and progression. However, exploring this relationship is hindered by the intricacies of mammalian models. Drosophila has the potential to be an excellent model organism for studies …
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Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells
… prostanoid and play an important role in brain disease through binding to four G protein-coupled receptor (EP1-4). However, there have been contradictory reports on its actions in inflammation processes. For instance, PGE2 inhibits or stimulates ICAM-1 expression depending on the cell type …
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Computation and Numerics in Neurostimulation
… success as an intervention for neurodegenerative diseases, including Parkinson's disease, in addition to a range of other neurological and psychiatric disorders. In an effort to enhance the medical efficacy and comprehension of this form of brain therapy, modeling and computational simulation are …
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Malarial retinopathy and neurovascular injury in paediatric cerebral malaria
Background Diseases of the brain are difficult to study because this organ is relatively inaccessible. Only one part of the central nervous system is available to direct, non-invasive observation – the retina. The concept of the retina as a window to the brain has created much interest in the …
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Neuromuscular Dysfunction as a Novel Indicator for Alzheimer's Disease and Response to Intervention in the 5xFAD Model
Alzheimer's disease (AD) develops along a continuum that spans years to decades before cognitive decline and clinical diagnosis. Preclinical AD is often associated with decreased muscle function and mitochondrial respiration, but the cause of these peripheral phenotypes in a brain disease remains …
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Preparation, characterisation and transcriptome analysis of RNA frm human vCJD brains.
… mechanisms of variant Creutzfeldt-Jakob disease (vCJD) in the human brain remain poorly understood. Gene expression data may provide insight into the molecular mechanisms involved. This requires analysis of human postmortem brain tissue however; the variability in RNA preparations from …
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Elasticity and Hegemony: A Brief History of Addiction Narrative in the Postwar United States
… been supposed to be everything from a chronic brain disease to a moral failing. Given that range, literary studies of addiction are often led to define addiction in narrow ways rather than examine the dynamic character of addiction over time. While previous works offer insight into specific …
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Familial Alzheimer's Disease Mutations in Presenilins Disrupt Endoplasmic Reticulum Calcium Leak
Alzheimer disease (AD) is the most common form of progressive dementia in adults over the age of 65 years. AD is a fatal brain disease and it currently affects about 27 million people worldwide. It is speculated that the number of people affected by AD will quadruple by 2050. The presence of …
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Functional Interplay Between Neurocognitive Decline and Risk Factors in Older Adults: A Multivariate Latent Growth Curve Model of Risk
Alzheimer’s disease (AD) is a heterogeneous brain disease with multiple interacting risk factors, suggesting equifinality. Research indicates that the pathophysiological processes involved in AD are evident years prior to disease onset with significant variability in neurocognitive functioning …
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Multi-functional Holographic Acoustic Lenses for Modulating Low- to High-Intensity Focused Ultrasound
… to improve the quality of life for patients with brain disease by minimizing the treatment time and optimizing the ultrasonic energy into the region of interest. We will also delve into the nonlinear regime for High-Intensity Focused Ultrasound (HIFU) applications, this study is structured under …
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Machine Learning for Tract Segmentation in dMRI data
… pathways of axons within the white matter of the brain as a set of streamlines, called tractography. A streamline is a vectorial representation of thousands of neuronal axons expressing structural connectivity. An important task is to group the same functional streamlines into one tract …
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Gold Nanoparticles as a Delivery System of Oligonucleotides into the Brain
The treatment of brain disease is challenging due to the blood-brain barrier, a physiological structure that prevents the majority of potential therapeutic agents from entering the brain. One approach to overcome this problem is the use of nanoparticles as a delivery system. Several types of …
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